Sulforaphane Protects against High Cholesterol-Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreaticβ-Cells Function

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

(2016) Kah Ni Tan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

(2016) Isabel Denzer et al.   PHARMACOLOGICAL RESEARCH

3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2

(2016) Huiting Xue et al.   XENOBIOTICA

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies

(2016) Catalina Carrasco-Pozo et al.   Redox Biology

Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death

(2015) Su Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural Nrf2 activators in diabetes

(2015) Angélica Saraí Jiménez-Osorio et al.   CLINICA CHIMICA ACTA

3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

(2015) Catalina Carrasco-Pozo et al.   EXPERIMENTAL CELL RESEARCH

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1

(2015) Kengo Suzuki et al.   PeerJ

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

(2014) Zhiguo Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

(2013) Samantha A Whitman et al.   EXPERIMENTAL CELL RESEARCH

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy

(2013) Mussie G. Hadera et al.   JOURNAL OF NEUROCHEMISTRY

Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation

(2013) Yanyan Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Divergent Effects of Sulforaphane on Basal and Glucose-Stimulated Insulin Secretion in β-Cells: Role of Reactive Oxygen Species and Induction of Endogenous Antioxidants

(2013) Jingqi Fu et al.   PHARMACEUTICAL RESEARCH

Effects of Plasma Membrane Cholesterol Level and Cytoskeleton F-Actin on Cell Protrusion Mechanics

(2013) Nima Khatibzadeh et al.   PLoS One

Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway

(2012) Chia-Yu Lin et al.   CYTOKINE

Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling

(2012) XIAOQIAN DAI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Prediabetes: a high-risk state for diabetes development

(2012) Adam G Tabák et al.   LANCET

Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc

(2012) Luc LeBlanc et al.   MOLECULES

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary intake of 337 polyphenols in French adults

(2011) Jara Pérez-Jiménez et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway

(2011) Xiuli Lu et al.   CELL STRESS & CHAPERONES

LC-MS/MS Quantification of Sulforaphane and Indole-3-carbinol Metabolites in Human Plasma and Urine after Dietary Intake of Selenium-Fortified Broccoli

(2011) Johanna Hauder et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design

(2011) John D. Clarke et al.   PHARMACOLOGICAL RESEARCH

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats

(2011) Leobardo Gaona-Gaona et al.   TOXICOLOGY

Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury

(2011) Eun-Mi Lee et al.   Diabetes & Metabolism Journal

Methyl-beta-cyclodextrin induces mitochondrial cholesterol depletion and alters the mitochondrial structure and bioenergetics

(2010) Wieslaw Ziolkowski et al.   FEBS LETTERS

Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity

(2009) Maria Lúcia Bonfleur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography–tandem mass spectrometry

(2009) Mireia Urpi-Sarda et al.   JOURNAL OF CHROMATOGRAPHY A

Cholesterol Depletion Reduces Helicobacter pylori CagA Translocation and CagA-Induced Responses in AGS Cells

(2008) C.-H. Lai et al.   INFECTION AND IMMUNITY

Bioavailability and Kinetics of Sulforaphane in Humans after Consumption of Cooked versus Raw Broccoli

(2008) Martijn Vermeulen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

(2008) Mi-Young Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY