Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment
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Title
Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment
Authors
Keywords
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Journal
CELL PROLIFERATION
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2023-03-14
DOI
10.1111/cpr.13448
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Note: Only part of the references are listed.- Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration
- (2022) Tangjun Zhou et al. Advanced Science
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- (2022) Chenglong Xie et al. Frontiers in Cell and Developmental Biology
- Manual therapy regulates oxidative stress in aging rat lumbar intervertebral discs through the SIRT1/FOXO1 pathway
- (2022) Chongjie Yao et al. Aging-US
- SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration
- (2022) Zhaoxin Ma et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma
- (2022) Sara Badodi et al. NEURO-ONCOLOGY
- Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine
- (2022) Isma Liza Mohd Isa et al. Advanced Healthcare Materials
- MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis
- (2022) Haiwei Ma et al. Cell Death Discovery
- Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative intervertebral discs
- (2022) Qifan Yu et al. Acta Biomaterialia
- Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes
- (2022) Wenchao Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals
- (2022) Liang Kang et al. Frontiers in Pharmacology
- Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration
- (2022) Xiangheng Dai et al. PeerJ
- Pathophysiology of RAGE in inflammatory diseases
- (2022) Hanbing Dong et al. Frontiers in Immunology
- Sirtuin Family and Diabetic Kidney Disease
- (2022) Che Bian et al. Frontiers in Endocrinology
- Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions
- (2022) Zhencong Li et al. Frontiers in Cell and Developmental Biology
- Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo
- (2022) Zhao Zhang et al. APOPTOSIS
- Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress
- (2022) Wen Yang et al. INFLAMMATION
- Telomere Shortening and Increased Oxidative Stress in Lumbar Disc Degeneration
- (2022) Manassanan Jitjumnong et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MiR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1
- (2022) Jiafang Zhang et al. SPINE
- Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy
- (2022) Linjun Yang et al. JOURNAL OF NANOBIOTECHNOLOGY
- Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration
- (2022) Zhilei Hu et al. Frontiers in Pharmacology
- Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway
- (2022) Yuandong Shao et al. Frontiers in Pharmacology
- Neuroprotective mechanisms of mangiferin in neurodegenerative diseases
- (2021) Tingjun Liu et al. DRUG DEVELOPMENT RESEARCH
- Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway
- (2021) Dawei Song et al. Oxidative Medicine and Cellular Longevity
- Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy
- (2021) Liwen Luo et al. STEM CELLS
- Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart
- (2021) Diana Bou-Teen et al. FREE RADICAL BIOLOGY AND MEDICINE
- SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress‐induced senescence of nucleus pulposus cells
- (2021) Jiayi Lin et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Estrogens as regulator of hematopoietic stem cell, immune cells and bone biology
- (2021) Rupali Sani Kumar et al. LIFE SCIENCES
- Nanostructured material–based electrochemical sensing of oxidative DNA damage biomarkers 8-oxoguanine and 8-oxodeoxyguanosine: a comprehensive review
- (2021) Ana-Maria Chiorcea-Paquim et al. Microchimica Acta
- The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe? (Review)
- (2021) Yongjin Li et al. Molecular Medicine Reports
- Roles of NLRP3 inflammasome in intervertebral disc degeneration
- (2021) G. Chao-yang et al. OSTEOARTHRITIS AND CARTILAGE
- Long Noncoding RNA ANPODRT Overexpression Protects Nucleus Pulposus Cells from Oxidative Stress and Apoptosis by Activating Keap1-Nrf2 Signaling
- (2021) Liang Kang et al. Oxidative Medicine and Cellular Longevity
- Regulation and metabolic functions of mTORC1 and mTORC2
- (2021) Angelia Szwed et al. PHYSIOLOGICAL REVIEWS
- Targeting Oxidative Stress with Amobarbital to Prevent Intervertebral Disc Degeneration
- (2021) Dongrim Seol et al. Spine Journal
- Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives
- (2021) Alessandra Altomare et al. Redox Biology
- Protein Oxidation - Formation Mechanisms, Detection and Relevance as Biomarkers in Human Diseases
- (2021) Richard Kehm et al. Redox Biology
- AGE/RAGE in diabetic kidney disease and ageing kidney
- (2021) Xia-Qing Wu et al. FREE RADICAL BIOLOGY AND MEDICINE
- STING Attenuates ROS Induced intervertebral disc degeneration
- (2021) Qiang Guo et al. OSTEOARTHRITIS AND CARTILAGE
- Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP/NLRP3/Caspase-1/IL-1β signaling pathway
- (2021) Yifan Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases
- (2021) Emilia Zgorzynska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intervertebral Disc Degeneration Models for Pathophysiology and Regenerative Therapy -Benefits and Limitations
- (2021) Yidian Wang et al. JOURNAL OF INVESTIGATIVE SURGERY
- Redox metabolism: ROS as specific molecular regulators of cell signaling and function
- (2021) Claudia Lennicke et al. MOLECULAR CELL
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- (2021) Xiaoqiang Cheng et al. MOLECULAR MEDICINE
- MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma
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- (2021) Huayi Li et al. Cancers
- Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration
- (2021) Zoe Krut et al. Cells
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- (2021) He Liang et al. Annals of Translational Medicine
- Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases
- (2021) Yi Yu et al. Cell Death Discovery
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- (2021) Hai-Jun Zhang et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2021) Rebecca Kritschil et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration
- (2021) Zhen Wang et al. Frontiers in Molecular Biosciences
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- (2020) Chao Jiang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway
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- (2020) Sandra K. Urbaniak et al. MOLECULES
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- (2020) Grace Y. Liu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review
- (2020) K. Sun et al. OSTEOARTHRITIS AND CARTILAGE
- Current Treatment Options for Intervertebral Disc Pathologies
- (2020) Stephen M. Eisenstein et al. Cartilage
- Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells
- (2020) Zhibiao Bai et al. Aging-US
- Targeting the MAPK Pathway in KRAS-Driven Tumors
- (2020) Matthias Drosten et al. CANCER CELL
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- (2020) Jicheng Yue et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology
- (2020) Petra Cazzanelli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cysteine depletion induces pancreatic tumor ferroptosis in mice
- (2020) Michael A. Badgley et al. SCIENCE
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- (2020) Carsten Carlberg et al. SEMINARS IN CANCER BIOLOGY
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- (2020) Ping-Chieh Pao et al. Nature Communications
- LIPID PEROXIDATION IN ATHEROSCLEROTIC CARDIOVASCULAR DISEASES
- (2020) Erica Gianazza et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2020) Danshuang He et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The emerging role of ferroptosis in inflammation
- (2020) Yitian Sun et al. BIOMEDICINE & PHARMACOTHERAPY
- Advanced glycation end products in diabetes, cancer and phytochemical therapy
- (2020) Begum Dariya et al. DRUG DISCOVERY TODAY
- Aging of the cells: Insight into cellular senescence and detection Methods
- (2020) Nor Shaheera Mohamad Kamal et al. EUROPEAN JOURNAL OF CELL BIOLOGY
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- (2020) Tao Bai et al. FREE RADICAL BIOLOGY AND MEDICINE
- Role of pyroptosis in liver diseases
- (2020) Abdullah Al Mamun et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment
- (2020) Qunhu Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma
- (2020) Yone Kawe Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances
- (2020) Chao Peng et al. Frontiers in Immunology
- Current Understanding of the Genetics of Intervertebral Disc Degeneration
- (2020) Peter J. Dickinson et al. Frontiers in Veterinary Science
- Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function
- (2020) Guang-Zhi Zhang et al. CLINICA CHIMICA ACTA
- Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer
- (2020) Sara E. Nunnery et al. DRUGS
- Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis
- (2020) Run‐Ze Yang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes
- (2020) Maria Tsingas et al. MATRIX BIOLOGY
- PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
- (2020) Rui Liu et al. Cell Death & Disease
- Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia
- (2020) Ishan Agrawal et al. Frontiers in Aging Neuroscience
- Ferroptosis: molecular mechanisms and health implications
- (2020) Daolin Tang et al. CELL RESEARCH
- Senescence and the SASP: many therapeutic avenues
- (2020) Jodie Birch et al. GENES & DEVELOPMENT
- A Molecular Perspective on Sirtuin Activity
- (2020) Carla S. S. Teixeira et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The treatment of intervertebral disc degeneration using Traditional Chinese Medicine
- (2020) Liguo zhu et al. JOURNAL OF ETHNOPHARMACOLOGY
- Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells
- (2020) Qian Xiang et al. Oxidative Medicine and Cellular Longevity
- MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis
- (2020) Lin Xie et al. Molecular Therapy-Nucleic Acids
- The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
- (2020) Keiko Taguchi et al. Cancers
- Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway
- (2020) Dong Wang et al. Frontiers in Cell and Developmental Biology
- Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver
- (2020) Erika Ramos-Tovar et al. Antioxidants
- Protein carbonylation: molecular mechanisms, biological implications, and analytical approaches
- (2020) Mitsugu Akagawa FREE RADICAL RESEARCH
- Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition
- (2019) Yu Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Cysteine Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress
- (2019) Xiaoyun Fu et al. Scientific Reports
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
- (2019) Matthew Dodson et al. Redox Biology
- Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy
- (2019) J. Wong et al. OSTEOARTHRITIS AND CARTILAGE
- Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- (2019) Dong Xu et al. MOLECULES
- Age-dependent expression of the Vitamin D receptor and the protective effect of Vitamin D receptor activation on H2O2-induced apoptosis in rat intervertebral disc cells
- (2019) Tong Tong et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Mitochondria and oxidative stress in ovarian endometriosis
- (2019) Chaolu Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2019) Joshua N. Farr et al. BONE
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- (2019) Mark S D’Arcy CELL BIOLOGY INTERNATIONAL
- MAPK/ERK Signaling in Regulation of Renal Differentiation
- (2019) Kurtzeborn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2019) Arianna Calcinotto et al. PHYSIOLOGICAL REVIEWS
- Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway
- (2019) Maojie Yang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2019) Lorenzo Galluzzi et al. CELL
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- (2019) Li-Ping Nan et al. CONNECTIVE TISSUE RESEARCH
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2019) Zhiliang Li et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Oxidative stress-induced senescence markedly increases disc cell bioenergetics
- (2019) Prashanti Patil et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration
- (2019) Zehan Tang et al. Cell Death & Disease
- Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
- (2019) Toshitaka Nakamura et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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- (2019) Wen-Ning Xu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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- (2019) Elise Lévy et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2019) Pallab Shaw et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2019) Yuan Fang et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2019) Jessica N. Peoples et al. EXPERIMENTAL AND MOLECULAR MEDICINE
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- (2019) Matthew J. Silva et al. FASEB JOURNAL
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- (2019) Emil List Larsen et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2019) Liang Kang et al. LIFE SCIENCES
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- (2019) Liang Kang et al. Oxidative Medicine and Cellular Longevity
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- (2019) Jinyu Bai et al. Advanced Healthcare Materials
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- (2018) Ramin Ghodsi et al. AMINO ACIDS
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- (2018) Qiongyuan Hu et al. Cell Death & Disease
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- Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc
- (2017) Ke Chen et al. Oxidative Medicine and Cellular Longevity
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- (2016) Zhixiao Yao et al. INFLAMMATION
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- ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
- (2016) Pierpaola Davalli et al. Oxidative Medicine and Cellular Longevity
- The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
- (2016) Heidi Martini-Stoica et al. TRENDS IN NEUROSCIENCES
- Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
- (2016) Deheng Chen et al. Cell Death & Disease
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Inflammation in intervertebral disc degeneration and regeneration
- (2015) M. Molinos et al. Journal of the Royal Society Interface
- Oxidative Stress and Adipocyte Biology: Focus on the Role of AGEs
- (2015) Florence Boyer et al. Oxidative Medicine and Cellular Longevity
- Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration
- (2015) Satoshi Suzuki et al. ARTHRITIS RESEARCH & THERAPY
- Oxidative stress participates in age-related changes in rat lumbar intervertebral discs
- (2014) Gang Hou et al. ARCHIVES OF GERONTOLOGY AND GERIATRICS
- Differential expression of extracellular-signal-regulated kinase 5 (ERK5) in normal and degenerated human nucleus pulposus tissues and cells
- (2014) Weiguo Liang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oxidative stress and autophagy: the clash between damage and metabolic needs
- (2014) G Filomeni et al. CELL DEATH AND DIFFERENTIATION
- Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis
- (2014) Dazhi Yang et al. CONNECTIVE TISSUE RESEARCH
- Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress
- (2014) Jong-Soo Park et al. INTERNATIONAL ORTHOPAEDICS
- The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review
- (2014) Priscilla Y. Hwang et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- Autophagy—a key player in cellular and body metabolism
- (2014) Kook Hwan Kim et al. Nature Reviews Endocrinology
- Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid
- (2013) Henrik E. Poulsen et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells
- (2013) Eun-Young Park et al. INTERNATIONAL ORTHOPAEDICS
- Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies
- (2013) Maria Fedorova et al. MASS SPECTROMETRY REVIEWS
- Role of cytokines in intervertebral disc degeneration: pain and disc content
- (2013) Makarand V. Risbud et al. Nature Reviews Rheumatology
- Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats
- (2012) Wei Ye et al. CONNECTIVE TISSUE RESEARCH
- Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration
- (2012) Libo Jiang et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Age-Related Oxidative Stress Compromises Endosomal Proteostasis
- (2012) Elvira S. Cannizzo et al. Cell Reports
- Free Radical Lipid Peroxidation: Mechanisms and Analysis
- (2011) Huiyong Yin et al. CHEMICAL REVIEWS
- Oxidative protein damage and the proteasome
- (2010) S. Grimm et al. AMINO ACIDS
- Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes
- (2009) J. Kim et al. OSTEOARTHRITIS AND CARTILAGE
- Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
- (2009) Ki-Won Kim et al. Spine Journal
- Many roads lead to oncogene-induced senescence
- (2008) S Courtois-Cox et al. ONCOGENE
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