Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

(2021) Guang‐Zhi Zhang et al.   CELL PROLIFERATION

Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects

(2021) Dan Huang et al.   Frontiers in Pharmacology

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury

(2020) Fan-Qi Kong et al.   Journal of Neuroinflammation

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

(2020) Hui Che et al.   eLife

Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo

(2020) Yifan Wu et al.   Frontiers in Pharmacology

The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells

(2020) Junichi Kushioka et al.   Scientific Reports

RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration

(2020) Zhenxuan Shao et al.   Frontiers in Cell and Developmental Biology

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

(2020) Z. Shao et al.   OSTEOARTHRITIS AND CARTILAGE

Critical role for arginase II in osteoarthritis pathogenesis

(2019) Wan-Su Choi et al.   ANNALS OF THE RHEUMATIC DISEASES

Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo

(2019) Ke Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells

(2019) Xiaoliang Bai et al.   BIOSCIENCE REPORTS

miR‐640 aggravates intervertebral disc degeneration via NF‐κB and WNT signalling pathway

(2019) Wengang Dong et al.   CELL PROLIFERATION

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

(2019) Zehan Tang et al.   Cell Death & Disease

TNF-α induces apoptosis of human nucleus pulposus cells via activating the TRIM14/NF-κB signalling pathway

(2019) Hao Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells

(2019) Weiwei Yi et al.   Aging-US

Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

(2019) Jialiang Lin et al.   Frontiers in Pharmacology

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

(2019) Yan Zhang et al.   Aging-US

Pioglitazone Protects Compression-Mediated Apoptosis in Nucleus Pulposus Mesenchymal Stem Cells by Suppressing Oxidative Stress

(2019) Yiqiang Hu et al.   Oxidative Medicine and Cellular Longevity

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice

(2018) Mariam Choudry et al.   IMMUNOLOGY

Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways

(2018) Pengcheng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats

(2018) Xiexing Wu et al.   Cell Death & Disease

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration

(2017) Liang Kang et al.   EXPERIMENTAL CELL RESEARCH

Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways

(2017) Chencheng Feng et al.   Oxidative Medicine and Cellular Longevity

Arginase-II Deficiency Extends Lifespan in Mice

(2017) Yuyan Xiong et al.   Frontiers in Physiology

Delivery systems for the treatment of degenerated intervertebral discs

(2015) S.B.G. Blanquer et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral supplementation of diabetic mice with propolis restores the proliferation capacity and chemotaxis of B and T lymphocytes towards CCL21 and CXCL12 by modulating the lipid profile, the pro-inflammatory cytokine levels and oxidative stress

(2015) Ahmad A. Al Ghamdi et al.   BMC IMMUNOLOGY

Effects of Nuclear Factor Kappa B Signaling Pathway in Human Intervertebral Disc Degeneration

(2015) Sun Zhongyi et al.   SPINE

Arginase: an old enzyme with new tricks

(2015) Ruth B. Caldwell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Arginase 2 Deficiency Prevents Oxidative Stress and Limits Hyperoxia-Induced Retinal Vascular Degeneration

(2014) Jutamas Suwanpradid et al.   PLoS One

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

(2012) Gautham Yepuri et al.   AGING CELL

Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc

(2009) Stephen M Richardson et al.   ARTHRITIS RESEARCH & THERAPY