MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

miR-24-3p induces human intervertebral disc degeneration by targeting insulin-like growth factor binding protein 5 and the ERK signaling pathway

(2020) Zhonghui Chen et al.   LIFE SCIENCES

Insights of stem cell-based endogenous repair of intervertebral disc degeneration

(2020) Yang Liu et al.   World Journal of Stem Cells

Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc

(2020) Nathan Piazza et al.   Frontiers in Bioengineering and Biotechnology

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair

(2019) Feng-Juan Lyu et al.   Nature Reviews Rheumatology

Apoptotic bodies from endplate chondrocytes enhance the oxidative stress‐induced mineralization by regulating PPi metabolism

(2019) Feng‐Lai Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Bioinformatic Analysis of MicroRNAs’ Role in Human Intervertebral Disc Degeneration

(2019) Xue-Qiang Wang et al.   PAIN MEDICINE

Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs

(2019) Hiroshi Ageta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New insights into extracellular vesicle biogenesis and function

(2019) Arash Latifkar et al.   JOURNAL OF CELL SCIENCE

MicroRNA-365 functions as a mechanosensitive microRNA to inhibit end plate chondrocyte degeneration by targeting histone deacetylase 4

(2019) Quan Zheng et al.   BONE

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

(2018) Jean M. Lewis et al.   ACS Nano

Functions and mechanisms of microRNA-31 in human cancers

(2018) Tao Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway

(2018) Zengjie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

(2018) Ming-liang Ji et al.   Nature Communications

Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration

(2017) Xiaofei Cheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative damage induces apoptosis and promotes calcification in disc cartilage endplate cell through ROS/MAPK/NF-κB pathway: Implications for disc degeneration

(2017) Yingchao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc

(2016) Qiaoqiao Zhu et al.   SPINE

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

(2016) J Xiao et al.   Cell Death & Disease

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

(2015) Daisuke Sakai et al.   Nature Reviews Rheumatology

A Systematic Review of Preclinical Studies on the Therapeutic Potential of Mesenchymal Stromal Cell-Derived Microvesicles

(2014) Celine Akyurekli et al.   Stem Cell Reviews and Reports

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The effects of microenvironment in mesenchymal stem cell–based regeneration of intervertebral disc

(2013) Yong-Can Huang et al.   Spine Journal

Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats

(2009) Chang-Qing Zhao et al.   AGE

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

(2009) Tian Sheng Chen et al.   NUCLEIC ACIDS RESEARCH

Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region

(2009) Helena B. Henriksson et al.   SPINE