Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

(2022) Nur Izzah Md Fadilah et al.   Polymers

Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc

(2021) Honor Morris et al.   ANNALS OF THE RHEUMATIC DISEASES

Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

(2021) Laura Baumgartner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Injectable Hyaluronic Acid Hydrogel Promotes Intervertebral Disc Repair in A Rabbit Model

(2021) Masahiro Inoue et al.   SPINE

Treatment Preferences for Chronic Low Back Pain: Views of Veterans and Their Providers

(2021) Ilana Belitskaya-Levy et al.   Journal of Pain Research

Current Update of Collagen Nanomaterials—Fabrication, Characterisation and Its Applications: A Review

(2021) Samantha Lo et al.   Pharmaceutics

Platelet-Derived Growth Factor Stimulated Migration of Bone Marrow Mesenchymal Stem Cells into an Injectable Gelatin-Hydroxyphenyl Propionic Acid Matrix

(2021) Wanting Niu et al.   Biomedicines

Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells

(2021) Kosuke Sako et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

(2021) Anca Maria Juncan et al.   MOLECULES

Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration

(2021) Alvin Bacero Bello et al.   npj Regenerative Medicine

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative

(2021) Christine L. Le Maitre et al.   JOR Spine

Cannabinoids in the Treatment of Back Pain

(2020) Teddy E Kim et al.   NEUROSURGERY

Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease

(2020) Pang Hung Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose

(2020) Dilip Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis

(2020) Trevor Thompson et al.   Systematic Reviews

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

The STarT Back stratified care model for nonspecific low back pain

(2020) James A. Hall et al.   PAIN

Genomics and Transcriptomics: The Powerful Technologies in Precision Medicine

(2020) Ali Khodadadian et al.   International Journal of General Medicine

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

(2020) Vivian Tam et al.   eLife

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair

(2019) Feng-Juan Lyu et al.   Nature Reviews Rheumatology

Reactive Oxygen Species‐Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disk Degeneration

(2019) Jinyu Bai et al.   Advanced Healthcare Materials

Antioxidant functionalized polymer capsules to prevent oxidative stress

(2018) Aitor Larrañaga et al.   Acta Biomaterialia

Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview

(2018) Crystian B. Oliveira et al.   EUROPEAN SPINE JOURNAL

Prevention and treatment of low back pain: evidence, challenges, and promising directions

(2018) Nadine E Foster et al.   LANCET

An experimental toolbox for characterization of mammalian collagen type I in biological specimens

(2018) Héctor Capella-Monsonís et al.   Nature Protocols

The influence of spinal-pelvic parameters on the prevalence of endplate Modic changes in degenerative thoracolumbar/lumbar kyphosis patients

(2018) Weiwei Xia et al.   PLoS One

Indication Variability in Degenerative Lumbar Spine Surgery

(2018) Bertrand Debono et al.   SPINE

Notochordal Cell Matrix As a Therapeutic Agent for Intervertebral Disc Regeneration

(2018) Stefan de Vries et al.   TISSUE ENGINEERING PART A

Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury

(2018) Isma Liza Mohd Isa et al.   Science Advances

Notochordal cell matrix: An inhibitor of neurite and blood vessel growth?

(2018) Stefan A.H. de Vries et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc

(2018) Ricardo Rodrigues-Pinto et al.   Scientific Reports

Injectable and Gellable Chitosan Formulations Filled with Cellulose Nanofibers for Intervertebral Disc Tissue Engineering

(2018) Ingo Doench et al.   Polymers

Engineering patient-specific bioprinted constructs for treatment of degenerated intervertebral disc

(2018) João Bebiano Costa et al.   Materials Today Communications

Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks

(2017) Michelle A. Cruz et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Influence of postoperative sagittal balance and spinopelvic parameters on the outcome of patients surgically treated for degenerative lumbar spondylolisthesis

(2017) Ingrid Radovanovic et al.   JOURNAL OF NEUROSURGERY-SPINE

Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: What's in it for humans?

(2017) Anna R. Tellegen et al.   Journal of Tissue Engineering and Regenerative Medicine

Thermally triggered injectable hydrogel, which induces mesenchymal stem cell differentiation to nucleus pulposus cells: Potential for regeneration of the intervertebral disc

(2016) A.A. Thorpe et al.   Acta Biomaterialia

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model

(2016) John T. Martin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

(2016) Jing-kun Li et al.   Journal of Translational Medicine

Towards precision medicine

(2016) Euan A. Ashley   NATURE REVIEWS GENETICS

Peptide:glycosaminoglycan hybrid hydrogels as an injectable intervention for spinal disc degeneration

(2016) D. E. Miles et al.   Journal of Materials Chemistry B

Riboflavin crosslinked high-density collagen gel for the repair of annular defects in intervertebral discs: An in vivo study

(2015) Peter Grunert et al.   Acta Biomaterialia

Hyaluronic Acid Based Hydrogels Attenuate Inflammatory Receptors and Neurotrophins in Interleukin-1β Induced Inflammation Model of Nucleus Pulposus Cells

(2015) Isma Liza Mohd Isa et al.   BIOMACROMOLECULES

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

(2015) Daisuke Sakai et al.   Nature Reviews Rheumatology

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug

(2015) Morakot Likhitpanichkul et al.   Spine Journal

Screening of hyaluronic acid–poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis

(2014) Claire G. Jeong et al.   Acta Biomaterialia

Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model

(2014) John T. Martin et al.   Acta Biomaterialia

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Enhancing cell migration in shape-memory alginate–collagen composite scaffolds: In vitro and ex vivo assessment for intervertebral disc repair

(2014) Olivier Guillaume et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Injectable, high-density collagen gels for annulus fibrosus repair: Anin vitrorat tail model

(2014) Brandon Borde et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biological performance of cell-encapsulated methacrylated gellan gum-based hydrogels for nucleus pulposus regeneration

(2014) Roman Tsaryk et al.   Journal of Tissue Engineering and Regenerative Medicine

Silk fibroin porous scaffolds for nucleus pulposus tissue engineering

(2014) Chao Zeng et al.   Materials Science & Engineering C-Materials for Biological Applications

Microgel Microenvironment Primes Adipose-Derived Stem Cells Towards an NP Cells-Like Phenotype

(2014) Gianluca Fontana et al.   Advanced Healthcare Materials

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

An injectable hydrogel incorporating mesenchymal precursor cells and pentosan polysulphate for intervertebral disc regeneration

(2013) Jessica E. Frith et al.   BIOMATERIALS

Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration

(2013) Aubrey T. Francisco et al.   BIOMATERIALS

Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration

(2013) Jessica E. Frith et al.   BIOMATERIALS

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

A validated new histological classification for intervertebral disc degeneration

(2013) J.P.H.J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Novel Treatment of Neuroinflammation Against Low Back Pain by Soluble Fullerol Nanoparticles

(2013) Qihai Liu et al.   SPINE

Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells

(2013) Marianna Peroglio et al.   Spine Journal

In situ forming hydrogels composed of oxidized high molecular weight hyaluronic acid and gelatin for nucleus pulposus regeneration

(2012) Yu-Chun Chen et al.   Acta Biomaterialia

Genome-Wide Analysis of Pain-, Nerve- and Neurotrophin -Related Gene Expression in the Degenerating Human Annulus

(2012) Helen E Gruber et al.   Molecular Pain

Annulus Fissures Are Mechanically and Chemically Conducive to the Ingrowth of Nerves and Blood Vessels

(2012) Manos Stefanakis et al.   SPINE

T1ρ Magnetic Resonance Imaging Quantification of Early Lumbar Intervertebral Disc Degeneration in Healthy Young Adults

(2012) Bruno Beomonte Zobel et al.   SPINE

IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1beta mediated degradation of nucleus pulposus in vitro

(2012) Deborah J Gorth et al.   ARTHRITIS RESEARCH & THERAPY

An injectable vehicle for nucleus pulposus cell-based therapy

(2011) Estelle C. Collin et al.   BIOMATERIALS

Chronic pain in the Republic of Ireland—Community prevalence, psychosocial profile and predictors of pain-related disability: Results from the Prevalence, Impact and Cost of Chronic Pain (PRIME) study, Part 1

(2011) Miriam N. Raftery et al.   PAIN

Regeneration of the Intervertebral Disc With Nucleus Pulposus Cell-Seeded Collagen II/Hyaluronan/Chondroitin-6-Sulfate Tri-Copolymer Constructs in a Rabbit Disc Degeneration Model

(2011) Bo Huang et al.   SPINE

Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres

(2011) Minting Yuan et al.   Spine Journal

Interleukin-1β induces angiogenesis and innervation in human intervertebral disc degeneration

(2010) Jae Man Lee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Health-related quality of life: a comparison of outcomes after lumbar fusion for degenerative spondylolisthesis with large joint replacement surgery and population norms

(2010) Sabarul A. Mokhtar et al.   Spine Journal

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus

(2009) Nandan L. Nerurkar et al.   NATURE MATERIALS

Fibrin promotes proliferation and matrix production of intervertebral disc cells cultured in three-dimensional poly(lactic-co-glycolic acid) scaffold

(2008) Munirah Sha'ban et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

(2008) A. J. Freemont   RHEUMATOLOGY

Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment

(2008) P. Prithvi Raj   Pain Practice