Article
Fisheries
Crystal L. Sweeney, Clarke A. M. Brown, Jessica L. Bennett, Neil W. Ross, Graham A. Gagnon
Summary: This study evaluated and validated a QuEChERS technique for extraction of estrogens from aquaculture waste solids and quantitation via LC-MS/MS. The results indicate that this method can be used for quantitation of E2 in aquaculture waste solids.
Review
Biochemistry & Molecular Biology
Zoe B. Mills, Richard L. M. Faull, Andrea Kwakowsky
Summary: Alzheimer's disease disproportionately affects women, with two thirds of all cases being female. The decline in estrogen levels during menopause is believed to be a contributing factor to the higher risk of developing AD in women. This review evaluates the impact of estrogen and hormone replacement therapy on cognition in women, and discusses the conflicting findings regarding the use of HRT as a preventive or therapeutic option for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Fernanda Bento Rosa Gomes, Pedro Antonio Alves Fernandes, Sue Ellen Costa Bottrel, Emanuel Manfred Freire Brandt, Renata de Oliveira Pereira
Summary: In recent decades, the expansion of livestock and animal feeding operations has led to elevated levels of estrogens in the environment. This review examines the fate, occurrence, and removal of different forms of estrogens in livestock wastewaters. The results indicate high concentrations of estrogens in swine farming samples and frequent findings of E1 and E2 in wastewaters from bovine, swine, and other livestock effluents. Aerobic treatment processes are more effective in estrogen removal, while anaerobic systems show poor efficiency. Various treatment methods, such as constructed wetlands and membrane bioreactors, have been reported to remove up to 90% of estrogens and estrogenic activity. Monitoring these compounds in environmental matrices is crucial, given the high concentrations found in livestock wastewaters and the reported removal efficiencies of anaerobic processes commonly used for their treatment.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Cui Ye, Minqiang Wang, Jihong Min, Roland Yingjie Tay, Heather Lukas, Juliane R. Sempionatto, Jiahong Li, Changhao Xu, Wei Gao
Summary: This study presents a wearable aptamer nanobiosensor that can automatically and non-invasively monitor oestradiol levels in sweat. The sensor utilizes a reagentless and amplification-free detection approach with a gold nanoparticle-MXene-based electrode, offering high sensitivity with a low limit of detection. The integrated system enables autonomous sweat induction, precise microfluidic sampling, real-time analysis and calibration, as well as wireless communication with a user interface. Results from human participants demonstrate cyclical fluctuations in sweat oestradiol during menstrual cycles, with a strong correlation between sweat and blood oestradiol levels. This technology opens up possibilities for non-invasive and personalized reproductive hormone monitoring.
NATURE NANOTECHNOLOGY
(2023)
Review
Hematology
Renata M. Booyens, Anna-Mart Engelbrecht, Ledivia Strauss, Etheresia Pretorius
Summary: Untreated menopause can have serious health implications, and while treatments are available, they may also have dangerous side effects. Various treatments, such as hormone therapy and bioidentical hormones, can relieve menopausal symptoms. However, these treatments may also affect blood coagulation and increase the risk of venous thromboembolism.
THROMBOSIS RESEARCH
(2022)
Review
Biology
Shiru Yuan, Guohuan Sun, Yawen Zhang, Fang Dong, Hui Cheng, Tao Cheng
Summary: The study describes the SMART model developed based on data from HSC studies, aiming to delineate the key characteristics of adult stem cells and speculate on the physiological relevance of stem cells in other tissues. Efforts are now being made to understand ASC biology and develop safe and effective ASC-based therapies.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Chemistry, Medicinal
Weronika Szybiak, Barbara Kujawa, Milosz Miedziaszczyk, Katarzyna Lacka
Summary: This study examined the relationship between treatment for Turner syndrome (TS) and bone mineral density (BMD) of the lumbar spine. The results showed that estrogen replacement therapy (ERT) significantly increased BMD and reduced the risk of fractures in patients with TS, while growth hormone therapy (GHT) did not improve bone density. However, supplementing growth hormone had beneficial effects on the clinical presentation of TS.
Review
Critical Care Medicine
Eric Lang, Hossam Abdou, Joseph Edwards, Neerav Patel, Jonathan J. Morrison
Summary: Trauma-hemorrhage is a major cause of death both before and early in hospitalization, and it also contributes to the development of organ dysfunction/failure and sepsis. Sex hormone therapy, including estradiol and its derivatives, has shown beneficial effects in animal models. Gender-based differences in mortality following trauma-hemorrhage have been observed, suggesting a role for estrogens.
Article
Medicine, General & Internal
Jaehoon Lee, Yuntae Kim, Hyunji Park, Changsoo Kim, Sihyun Cho, Jongyoun Kim
Summary: This study investigated the association between different types of hormone replacement therapy (HRT) and atrial fibrillation (AF). The findings showed that current HRT users, except those using estradiol-only HRT, had significantly elevated AF risk, while past users who used estradiol plus progestin HRT had a reduced AF risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
D. -H. Lu, S. -Y. Zhou, L. -Z. Xu
Summary: This study systematically reviewed and meta-analyzed the effects of hormone replacement therapy (HRT) on the hormonal profile of postmenopausal women. The analysis showed that oral and transdermal HRT increased estradiol (E2) levels and decreased follicle stimulating hormone (FSH) levels, while vaginal HRT did not have a significant effect. There were no significant changes in E2 and FSH levels between different treatment durations or regimes. However, oral estrogen combined with synthetic progestin led to a reduction in sex hormone-binding globulin (SHGB) levels.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
D. -H. Lu, S. -Y. Zhou, L. -Z. Xu
Summary: The aim of this study was to systematically review and meta-analyze the changes in hormonal profile of postmenopausal women treated with hormone replacement therapy (HRT). The results showed that oral and transdermal HRT increased estradiol (E2) serum levels and decreased follicle stimulating hormone (FSH) levels, while vaginal HRT had no effect. There was no significant difference in the effects of different HRT regimens on E2 and FSH levels.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jari E. Karppinen, Petri Wiklund, Johanna K. Ihalainen, Hanna-Kaarina Juppi, Ville Isola, Matti Hyvarinen, Essi K. Ahokas, Urho M. Kujala, Jari Laukkanen, Juha J. Hulmi, Juha P. Ahtiainen, Sulin Cheng, Eija K. Laakkonen
Summary: It is uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass-adjusted resting energy expenditure (REEadj). This study found that there is a significant difference in REEadj between middle-aged and younger women, as well as between middle-aged women with different menopausal statuses. The study also demonstrated that menopause may not contribute to the decline in REEadj in women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Myles H. Alderman, Hugh S. Taylor
Summary: The development of the female reproductive tract is influenced by estrogen and environmental factors. Exposure to xenoestrogens during critical periods can affect uterine morphology and increase the risk of disease later in life. Recent research suggests that these effects are related to epigenetic regulation of gene expression.
Article
Dermatology
Norifumi Urao, Jinghua Liu, Kentaro Takahashi, Gayathri Ganesh
Summary: The status of hematopoietic stem cells (HSCs) is crucial for wound healing responses, with recent advances shedding light on the role of myeloid cells and the importance of understanding HSC functions. Future research on HSCs producing blood cells could lead to the development of blood biomarkers predicting chronic wounds, revolutionizing wound care with precision medicine for high-risk patients.
ADVANCES IN WOUND CARE
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
