Inflammation in intervertebral disc degeneration and regeneration

The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs

(2014) Catarina Leite Pereira et al.   BIOMATERIALS

Potential regenerative treatment strategies for intervertebral disc degeneration in dogs

(2014) Frances C Bach et al.   BMC Veterinary Research

Inhibiting IκB Kinase-β Downregulates Inflammatory Cytokines in Injured Discs and Neuropeptides in Dorsal Root Ganglia Innervating Injured Discs in Rats

(2014) Sayako Kobori et al.   SPINE

High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain

(2014) Rahul Gawri et al.   ARTHRITIS RESEARCH & THERAPY

Fibrinogen promotes resorption of chitosan by human osteoclasts

(2013) A.L. Torres et al.   Acta Biomaterialia

Adsorbed fibrinogen leads to improved bone regeneration and correlates with differences in the systemic immune response

(2013) S.G. Santos et al.   Acta Biomaterialia

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift

(2013) D. Purmessur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc

(2013) Sarit Sara Sivan et al.   EUROPEAN SPINE JOURNAL

Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells

(2013) Hua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging

(2013) Bashar Akhatib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues

(2013) Wen Zhang et al.   PLoS One

Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells In Vitro

(2013) Jun Chen et al.   PLoS One

The Transpedicular Approach As an Alternative Route for Intervertebral Disc Regeneration

(2013) Gianluca Vadalà et al.   SPINE

Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells

(2013) Christopher K. Kepler et al.   SPINE

Expression and Relationship of Proinflammatory Chemokine RANTES/CCL5 and Cytokine IL-1β in Painful Human Intervertebral Discs

(2013) Christopher K. Kepler et al.   SPINE

Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells—a potential novel treatment for intervertebral disc degeneration

(2013) Qihai Liu et al.   Spine Journal

Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

(2013) Nam V. Vo et al.   Spine Journal

Adsorbed Fibrinogen Enhances Production of Bone- and Angiogenic-Related Factors by Monocytes/Macrophages

(2013) Joana Maciel et al.   TISSUE ENGINEERING PART A

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

(2013) Lilian Quero et al.   ARTHRITIS RESEARCH & THERAPY

The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc

(2013) Kate L E Phillips et al.   ARTHRITIS RESEARCH & THERAPY

Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system

(2013) Brian H Chon et al.   Stem Cell Research & Therapy

Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats

(2012) Toru Takada et al.   ARTHRITIS AND RHEUMATISM

“Transflammation”: When Innate Immunity Meets Induced Pluripotency

(2012) Luke A.J. O’Neill   CELL

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

Quantitative Proteomic Analysis of Eight Cartilaginous Tissues Reveals Characteristic Differences as well as Similarities between Subgroups

(2012) Patrik Önnerfjord et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational pharmacokinetics of solute penetration into human intervertebral discs—Effects of endplate permeability, solute molecular weight and disc size

(2012) S. Motaghinasab et al.   JOURNAL OF BIOMECHANICS

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Rabbit Notochordal Cells Modulate the Expression of Inflammatory Mediators by Human Annulus Fibrosus Cells Cocultured With Activated Macrophage-Like THP-1 Cells

(2012) Joo Han Kim et al.   SPINE

Homing of Mesenchymal Stem Cells in Induced Degenerative Intervertebral Discs in a Whole Organ Culture System

(2012) Svenja Illien-Jünger et al.   SPINE

Intervertebral Disc-Derived Stem Cells

(2012) W. Mark Erwin et al.   SPINE

Intervertebral disc disease in dogs – Part 1: A new histological grading scheme for classification of intervertebral disc degeneration in dogs

(2012) N. Bergknut et al.   VETERINARY JOURNAL

IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1beta mediated degradation of nucleus pulposus in vitro

(2012) Deborah J Gorth et al.   ARTHRITIS RESEARCH & THERAPY

Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis

(2011) Chia-Che Wu et al.   BIOMATERIALS

Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples

(2011) Yasuo Kokubo et al.   JOURNAL OF NEUROSURGERY-SPINE

Calcification in human intervertebral disc degeneration and scoliosis

(2011) Gergana I. Hristova et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials

(2011) C. R. Almeida et al.   Journal of the Royal Society Interface

Rhein: A potential biological therapeutic drug for intervertebral disc degeneration

(2011) Hao Li et al.   MEDICAL HYPOTHESES

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

(2011) Darwin J Prockop et al.   MOLECULAR THERAPY

Complex loading affects intervertebral disc mechanics and biology

(2011) B.A. Walter et al.   OSTEOARTHRITIS AND CARTILAGE

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

(2011) Andreas Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Inflammatory Events in Human Intervertebral Disc Cells With a Tumor Necrosis Factor Antagonist

(2011) S. Michael Sinclair et al.   SPINE

The Red Wine Polyphenol Resveratrol Shows Promising Potential for the Treatment of Nucleus Pulposus–Mediated Pain In Vitro and In Vivo

(2011) Karin Wuertz et al.   SPINE

Support of Concept That Migrating Progenitor Cells From Stem Cell Niches Contribute to Normal Regeneration of the Adult Mammal Intervertebral Disc

(2011) Helena Barreto Henriksson et al.   SPINE

Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model

(2011) Steven K. Leckie et al.   Spine Journal

Harnessing and Modulating Inflammation in Strategies for Bone Regeneration

(2011) Paschalia M. Mountziaris et al.   TISSUE ENGINEERING PART B-REVIEWS

Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study

(2011) Lluis Orozco et al.   TRANSPLANTATION

Adalimumab in severe and acute sciatica: A multicenter, randomized, double-blind, placebo-controlled trial

(2010) Stéphane Genevay et al.   ARTHRITIS AND RHEUMATISM

Extracellular matrix, inflammation, and the angiogenic response

(2010) A. G. Arroyo et al.   CARDIOVASCULAR RESEARCH

Human mesenchymal stem cell co-culture modulates the immunological properties of human intervertebral disc tissue fragments in vitro

(2010) Alessandro Bertolo et al.   EUROPEAN SPINE JOURNAL

Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model

(2010) Kenji Serigano et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

(2010) Mostafa A. Gabr et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Tumor Necrosis α-blocking Agent (Etanercept)

(2010) Tosan Okoro et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Comparative Expression of Matrix-associated Genes and Inflammatory Cytokines-associated Genes According to Disc Degeneration

(2010) Jeong Yoon Park et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

(2010) J. Y. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spine Infection/Inflammation

(2010) Jeffrey DeSanto et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

Activated Macrophage-Like THP-1 Cells Modulate Anulus Fibrosus Cell Production of Inflammatory Mediators in Response to Cytokines

(2010) Joo Han Kim et al.   SPINE

Disc Regeneration Therapy Using Marrow Mesenchymal Cell Transplantation

(2010) Takafumi Yoshikawa et al.   SPINE

Human Nucleus Pulposus Cells React to IL-6

(2010) Rebecca K. Studer et al.   SPINE

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits

(2010) Takashi Miyamoto et al.   ARTHRITIS RESEARCH & THERAPY

Spontaneous regression of a huge subligamentous extruded disc herniation: short report of an illustrative case

(2009) Ali Rıza Gezici et al.   ACTA NEUROCHIRURGICA

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Mesenchymal Stem Cell Homing: The Devil Is in the Details

(2009) Jeffrey M. Karp et al.   Cell Stem Cell

Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues

(2009) Keon Hee Yoo et al.   CELLULAR IMMUNOLOGY

Mechanisms involved in the therapeutic properties of mesenchymal stem cells

(2009) Lindolfo da Silva Meirelles et al.   CYTOKINE & GROWTH FACTOR REVIEWS

In vitro study of matrix metalloproteinase/tissue inhibitor of metalloproteinase production by mesenchymal stromal cells in response to inflammatory cytokines: the role of their migration in injured tissues

(2009) Tatiana Tondreau et al.   CYTOTHERAPY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

A Preliminary Report on the Effects of Sustained Administration of Corticosteroid on Traumatized Disc Using the Adult Male Rat Model

(2009) Ashraf A. Ragab et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

p38 MAPK inhibition selectively mitigates inflammatory mediators and VEGF production in AF cells co-cultured with activated macrophage-like THP-1 cells

(2009) J.H. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration

(2009) J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of phenotypic discriminating markers for intervertebral disc cells and articular chondrocytes

(2009) J. Clouet et al.   RHEUMATOLOGY

TNF-α Induces MMP2 Gelatinase Activity and MT1-MMP Expression in an In Vitro Model of Nucleus Pulposus Tissue Degeneration

(2009) Cheryle A. Séguin et al.   SPINE

Variation in Chondroadherin Abundance and Fragmentation in the Human Scoliotic Disc

(2009) Lisbet Haglund et al.   SPINE

Ultrastructural Analysis on Lumbar Disc Herniation Using Surgical Specimens

(2009) Shigeru Kobayashi et al.   SPINE

2009 ISSLS Prize Winner: Does Discography Cause Accelerated Progression of Degeneration Changes in the Lumbar Disc

(2009) Eugene J. Carragee et al.   SPINE

Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region

(2009) Helena B. Henriksson et al.   SPINE

Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals

(2009) Kenneth M. C. Cheung et al.   SPINE

Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model

(2009) Wayne Murrell et al.   Spine Journal

Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc

(2009) Helen E Gruber et al.   ARTHRITIS RESEARCH & THERAPY

Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc

(2009) Stephen M Richardson et al.   ARTHRITIS RESEARCH & THERAPY

Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury

(2009) Huina Zhang et al.   ARTHRITIS RESEARCH & THERAPY

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

The role of integrin binding sites in fibronectin matrix assembly in vivo

(2008) Michael Leiss et al.   CURRENT OPINION IN CELL BIOLOGY

Cell transplantation in lumbar spine disc degeneration disease

(2008) C. Hohaus et al.   EUROPEAN SPINE JOURNAL

Transplantation of mesenchymal stem cells in a canine disc degeneration model

(2008) Akihiko Hiyama et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

(2008) J. A. Hoyland et al.   RHEUMATOLOGY

IL-20 May Contribute to the Pathogenesis of Human Intervertebral Disc Herniation

(2008) Kuo-Yuan Huang et al.   SPINE

The Twin Spine Study: Contributions to a changing view of disc degeneration†

(2008) Michele C. Battié et al.   Spine Journal

Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration

(2008) Philip Jones et al.   ARTHRITIS RESEARCH & THERAPY

Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc

(2008) Helen E Gruber et al.   ARTHRITIS RESEARCH & THERAPY