Oxidative stress and autophagy: the clash between damage and metabolic needs

S-Nitrosoglutathione Reductase Deficiency-Induced S-Nitrosylation Results in Neuromuscular Dysfunction

(2014) Costanza Montagna et al.   ANTIOXIDANTS & REDOX SIGNALING

Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

(2014) E. Lopez-Rivera et al.   CANCER RESEARCH

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

(2014) David J. Roberts et al.   MOLECULAR CELL

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Mitochondrial dismissal in mammals, from protein degradation to mitophagy

(2013) Silvia Campello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer

(2013) Bhupendra Singh et al.   BMC CANCER

Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells

(2013) Chao Zhang et al.   CANCER LETTERS

mTOR, AMBRA1, and autophagy: An intricate relationship

(2013) Francesca Nazio et al.   CELL CYCLE

Autophagy and genomic integrity

(2013) A T Vessoni et al.   CELL DEATH AND DIFFERENTIATION

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

DNA alkylation damage and autophagy induction

(2013) Diana L. Bordin et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The return of the nucleus: transcriptional and epigenetic control of autophagy

(2013) Jens Füllgrabe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

(2013) D. N. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

New Insights into the Link Between DNA Damage and Apoptosis

(2012) Daniela De Zio et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production

(2012) Rongxue Wu et al.   EMBO Molecular Medicine

Autophagy and cell growth - the yin and yang of nutrient responses

(2012) T. P. Neufeld   JOURNAL OF CELL SCIENCE

Redox implications of AMPK-mediated signal transduction beyond energetic clues

(2012) S. Cardaci et al.   JOURNAL OF CELL SCIENCE

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

(2012) R V Durán et al.   ONCOGENE

DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase

(2012) F. Dotiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

(2012) S. B. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Loss of intestinal nuclei and intestinal integrity in aging C. elegans

(2011) Matthew D. McGee et al.   AGING CELL

Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA–PKcs and PARP-1

(2011) Jung-Hoon Yoon et al.   BIOCHEMICAL PHARMACOLOGY

The rate of oxygen utilization by cells

(2011) Brett A. Wagner et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents

(2011) H. Bae et al.   MOLECULAR CANCER RESEARCH

Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase 1

(2011) M. Dyavaiah et al.   MOLECULAR CANCER RESEARCH

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

DNA damage and autophagy

(2011) Humberto Rodriguez-Rocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy

(2010) Gian Maria Fimia et al.   Autophagy

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

The Cvt pathway as a model for selective autophagy

(2010) Melinda A. Lynch-Day et al.   FEBS LETTERS

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macroautophagy-Mediated Degradation of Whole Nuclei in the Filamentous Fungus Aspergillus oryzae

(2010) Jun-ya Shoji et al.   PLoS One

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Piecemeal microautophagy of the nucleus: Genetic and morphological traits

(2009) Roswitha Krick et al.   Autophagy

PARP-1 is involved in autophagy induced by DNA damage

(2009) José Antonio Muñoz-Gámez et al.   Autophagy

An Amino Acid Shuffle Activates mTORC1

(2009) Adiel Cohen et al.   CELL

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

A Tail-Anchored Myotonic Dystrophy Protein Kinase Isoform Induces Perinuclear Clustering of Mitochondria, Autophagy, and Apoptosis

(2009) Ralph J. A. Oude Ophuis et al.   PLoS One

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thiol Chemistry in Peroxidase Catalysis and Redox Signaling

(2008) Alberto Bindoli et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity

(2008) Barry W. Allen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE