Article
Endocrinology & Metabolism
Lisa Y. Lawson, Michael D. Brodt, Nicole Migotsky, Christopher J. Chermside-Scabbo, Ramya Palaniappan, Matthew J. Silva
Summary: The secretion of Wnt ligands is essential for adult bone homeostasis, and inhibiting their secretion results in decreased bone formation and increased resorption. Additionally, osteoblast-derived Wnts play a crucial role in mediating the bone anabolic response to tibial loading.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Maria L. Mace, Eva Gravesen, Anders Nordholm, Soeren Egstrand, Marya Morevati, Carsten Nielsen, Andreas Kjaer, Geert Behets, Patrick D'Haese, Klaus Olgaard, Ewa Lewin
Summary: Research suggests an association between lower bone mineral density and vascular calcification, with chronic kidney disease affecting mineral balance and bone turnover. The study demonstrates that the presence of vascular calcification leads to lower bone mineral density, impairs bone metabolism, and indicates a communication pathway between vasculature and bone tissue.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Tori Kroon, Neharika Bhadouria, Paul Niziolek, Daniel Edwards, Roy Choi, Erica L. Clinkenbeard, Alexander Robling, Nilsson Holguin
Summary: Intervertebral disc degeneration, a leading cause of low back pain, lacks pharmacological treatment options. This study demonstrated that neutralization of sclerostin and/or dkk1 could stimulate Wnt signaling and enhance intervertebral disc structure in mice. The findings suggest that anti-sclerostin antibody may contribute to the restoration of intervertebral disc health.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jan Willem Bek, Chen Shochat, Adelbert De Clercq, Hanna De Saffel, Annekatrien Boel, Juriaan Metz, Frans Rodenburg, David Karasik, Andy Willaert, Paul J. Coucke
Summary: By utilizing crispant screening in zebrafish, researchers were able to effectively validate the functional roles of osteoporosis candidate genes, demonstrating a promising approach for rapid functional screening in this field.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jonathan J. Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R. Ferreira, Amy F. Lewanda, Joshua E. Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q. Feng, Qian Xu, Yongbo Lu, Robert E. Hammer, Carol A. Wise, Bruce Beutler
Summary: Proper skeletal development requires coordination of complex molecular mechanisms, and disruption of these processes through genetic mutation can lead to skeletal abnormalities. The study successfully developed a high-throughput skeletal screening approach to identify genes essential for skeletal development, showing the feasibility of in vivo mutagenesis to create mouse models of skeletal disease and characterize mutations in developmentally essential genes like FAM20B. Results and engineered mouse models from the study are publicly available through the Mutagenetix database.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jun Wang, Yong Jiang, Xudong Xie, Shiwen Zhang, Chunmei Xu, Yinghong Zhou, Jian Q. Feng
Summary: This study demonstrates that murine molar root elongation is precisely regulated by Wnt/beta-catenin signaling within a narrow window of time, from newborn to the 5th day. Activation of beta-catenin at different time points affects the extent of root elongation, indicating a high sensitivity of root elongation to changes in beta-catenin levels.
Article
Endocrinology & Metabolism
John Garcia, Spenser S. Smith, Sangita Karki, Hicham Drissi, Henry H. Hrdlicka, Daniel W. Youngstrom, Anne M. Delany
Summary: miR-433-3p is a negative regulator of bone formation through various key signaling pathways such as PTH, MAPK, Wnt, and endogenous glucocorticoids, targeting multiple genes including Crebl, Hsd11b1, and Rspo3 to inhibit osteoblast activity and Wnt signaling pathway, reducing bone mass. In in vivo experiments, inhibitors of miR-433-3p can increase trabecular bone volume in mice, indicating its negative regulatory role in bone formation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Alice Costantini, Riikka E. Makitie, Markus A. Hartmann, Nadja Fratzl-Zelman, M. Carola Zillikens, Uwe Kornak, Kent Soe, Outi Makitie
Summary: Early-onset osteoporosis (EOOP) is a disease that affects children, premenopausal women, and men aged <50 years. It may be caused by various factors such as chronic illness, medication, and nutritional deficiencies. Genetic variants in key genes play a crucial role in the pathogenesis of EOOP. The diagnosis and genetic diagnosis of EOOP are complex and require comprehensive assessments. Rare monogenic forms of EOOP are mainly associated with gene defects in the WNT pathway.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Cell Biology
Kiran Bora, Neetu Kushwah, Meenakshi Maurya, Madeline C. Pavlovich, Zhongxiao Wang, Jing Chen
Summary: This article summarizes the major molecular signaling pathways involved in the development and maintenance of the inner blood-retinal barrier (iBRB), as well as representative animal models of eye diseases. The study highlights the research on the Wnt/beta-catenin signaling pathway. Additionally, various methods for detecting and analyzing vascular leakage are described. These experimental models and methods are valuable in understanding the molecular mechanisms of retinal vascular diseases and evaluating therapeutic drugs.
Article
Endocrinology & Metabolism
Erik F. Eriksen, Roland Chapurlat, Rogely Waite Boyce, Yifei Shi, Jacques P. Brown, Stephane Horlait, Donald Betah, Cesar Libanati, Pascale Chavassieux
Summary: The bone-forming agent romosozumab significantly increases modeling-based bone formation on cancellous and endocortical surfaces in the first 2 months of treatment, but not on periosteal surfaces. There was no significant difference in remodeling-based bone formation on all three bone surfaces after 2 months of romosozumab treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Peripheral Vascular Disease
Irena Kasacka, Zaneta Piotrowska, Natalia Domian, Magdalena Acewicz, Alicja Lewandowska
Summary: The study revealed alterations in Wnt/beta-catenin signaling in the kidneys of rats during hypertension, with the severity of these changes depending on the type of hypertension. This study is the first to assess the levels of some elements of the canonical Wnt/beta-catenin signal transduction pathway in various types of arterial hypertension by immunohistochemistry, and may lead to further molecular and functional studies of this pathway in hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Immunology
Mengjiao Zhang, Dongmei Yang, Honggang Yu, Qing Li
Summary: miR-497 is downregulated in inflammatory diseases but not in IBD. The study found that miR-497 can inhibit gut inflammation by suppressing the NF-kappa B pathway and cytokine release.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)