Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

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Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

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Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model

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Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

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Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

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AMPK: Potential Therapeutic Target for Ischemic Stroke

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Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

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TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux

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Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders

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GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells

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Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics

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Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer

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Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy

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Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

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Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways

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ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

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Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy

(2017) Xiaodong Li et al.   Nutrients

C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis

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Autophagy: A double-edged sword in intervertebral disk degeneration

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Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells

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Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

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Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

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MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis

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Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition

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Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes

(2015) ZHOUQING HUANG et al.   Molecular Medicine Reports

Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

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Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

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Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

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Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

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A systematic review and meta-synthesis of the impact of low back pain on people’s lives

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Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

(2014) Tiffany Kadow et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

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The benefits of multi-disciplinary research on intervertebral disc degeneration

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SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

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Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMP-Activated Protein Kinase

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Primary prevention of disc degeneration-related symptoms

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Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells

(2013) Kui Xiao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Comparison of biological processes induced in HepG2 cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol

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The molecular basis of intervertebral disc degeneration

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Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

(2012) Xiucui Ma et al.   CIRCULATION

Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats

(2012) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

(2012) Libo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Curcuminoids and resveratrol as anti-Alzheimer agents

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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

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Discovery of curcumin, a component of golden spice, and its miraculous biological activities

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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The Effect of Injection Volume on Disc Degeneration in a Rat Tail Model

(2011) Hua-jie Mao et al.   SPINE