Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine

(2014) Pierachille Santus et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells

(2013) Hua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

(2012) Makarand V. Risbud et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Obesity-induced tissue free radical generation: An in vivo immuno-spin trapping study

(2012) Nicholas K.H. Khoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

A transgenic mouse model for monitoring oxidative stress

(2012) Daisuke Oikawa et al.   Scientific Reports

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Monocarboxylate Transporter-1 Is Required for Cell Death in Mouse Chondrocytic ATDC5 Cells Exposed to Interleukin-1β via Late Phase Activation of Nuclear Factor κB and Expression of Phagocyte-type NADPH Oxidase

(2011) Kentaro Yoshimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

(2011) Nobuyuki Fujita et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine

(2011) Huina Zhang et al.   JOURNAL OF NEUROSURGERY-SPINE

The Red Wine Polyphenol Resveratrol Shows Promising Potential for the Treatment of Nucleus Pulposus–Mediated Pain In Vitro and In Vivo

(2011) Karin Wuertz et al.   SPINE

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord

(2010) Makarand V. Risbud et al.   DEVELOPMENTAL DYNAMICS

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Nucleus Pulposus Cells React to IL-6

(2010) Rebecca K. Studer et al.   SPINE

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM

Peroxynitrite Induces Gene Expression in Intervertebral Disc Cells

(2009) Lucy Poveda et al.   SPINE

Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

(2008) Berta Cillero-Pastor et al.   ARTHRITIS AND RHEUMATISM

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS’ role in disease

(2008) Olga V. Nemirovskiy et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

(2008) Bin Han et al.   SPINE