Causative Links between Protein Aggregation and Oxidative Stress: A Review

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

(2019) Xinhe Wang et al.   Acta Neuropathologica Communications

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

(2019) David Guerrero-Gómez et al.   CELL DEATH AND DIFFERENTIATION

Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage

(2018) K. Rajasekhar et al.   ACS Chemical Neuroscience

Modification of chickpea cystatin by reactive dicarbonyl species: Glycation, oxidation and aggregation

(2018) Sheraz Ahmad Bhat et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 Domain

(2018) Tessa R. Young et al.   BIOCHEMISTRY

Small Molecule Modulation of Proteasome Assembly

(2018) Evert Njomen et al.   BIOCHEMISTRY

Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells

(2018) Sanghamitra Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of iron on the aggregation propensity of the N-terminal fibrillogenic polypeptide of human apolipoprotein A-I

(2018) Rita Del Giudice et al.   BIOMETALS

α- and β-casein aggregation induced by riboflavin-sensitized photo-oxidation occurs via di-tyrosine cross-links and is oxygen concentration dependent

(2018) E. Fuentes-Lemus et al.   FOOD CHEMISTRY

Designing aptamers which respond to intracellular oxidative stress and inhibit aggregation of mutant huntingtin

(2018) Kinjal A. Patel et al.   FREE RADICAL BIOLOGY AND MEDICINE

SOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALS

(2018) Natalie E. Farrawell et al.   JOURNAL OF CELL SCIENCE

Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein

(2018) Dinendra L. Abeyawardhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adaptation of Mge1 to oxidative stress by local unfolding and altered Interaction with mitochondrial Hsp70 and Mxr2

(2018) Srinivasu Karri et al.   MITOCHONDRION

Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis

(2018) Cheng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and structural architecture of polyQ aggregates in yeast

(2018) Anselm Gruber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

(2018) Stefano Thellung et al.   Cell Death & Disease

Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates

(2018) Luana Palazzi et al.   Scientific Reports

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta

(2018) Silvia Hilt et al.   MOLECULES

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

(2018) Gabriele Civiletto et al.   EMBO Molecular Medicine

Attempt to Untangle the Prion-Like Misfolding Mechanism for Neurodegenerative Diseases

(2018) Daniela Sarnataro   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells

(2018) Yerin Kim et al.   Scientific Reports

Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and l-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson’s disease

(2017) Vinod Kumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The non-stop decay mRNA surveillance pathway is required for oxidative stress tolerance

(2017) Nur H. Jamar et al.   NUCLEIC ACIDS RESEARCH

Rethinking HSF1 in Stress, Development, and Organismal Health

(2017) Jian Li et al.   TRENDS IN CELL BIOLOGY

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

(2017) Clémence Cheignon et al.   Chemical Science

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

(2017) Lijuan Zhang et al.   MEDICAL SCIENCE MONITOR

Protein aggregation into insoluble deposits protects from oxidative stress

(2017) Anita Carija et al.   Redox Biology

Proteostasis, oxidative stress and aging

(2017) Ioanna Korovila et al.   Redox Biology

Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo

(2017) Anna Pepe et al.   Scientific Reports

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1

(2016) Drazen Petrov et al.   BIOPHYSICAL JOURNAL

An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin

(2016) Eugene Serebryany et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process

(2016) Giovanna Cenini et al.   MOLECULAR BIOLOGY OF THE CELL

p62 improves AD-like pathology by increasing autophagy

(2016) A Caccamo et al.   MOLECULAR PSYCHIATRY

Role of Carbonyl Modifications on Aging-Associated Protein Aggregation

(2016) Maya Tanase et al.   Scientific Reports

Distinct stress conditions result in aggregation of proteins with similar properties

(2016) Alan J. Weids et al.   Scientific Reports

Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA

(2015) Christian Dienemann et al.   BIOCHEMISTRY

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway

(2015) Danica Ciric et al.   JOURNAL OF VIROLOGY

Oxidative stress conditions increase the frequency ofde novoformation of the yeast [PSI+] prion

(2015) Victoria A. Doronina et al.   MOLECULAR MICROBIOLOGY

Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance

(2015) Cheryl Yung et al.   MOLECULAR NEUROBIOLOGY

Inhibition of Aggregation of Mutant Huntingtin by Nucleic Acid Aptamers In Vitro and in a Yeast Model of Huntington's Disease

(2015) Rajeev K Chaudhary et al.   MOLECULAR THERAPY

Effect of lysosomal and ubiquitin-proteasome system dysfunction on the abnormal aggregation of α-synuclein in PC12 cells

(2015) RUNQING WANG et al.   Experimental and Therapeutic Medicine

Proteome response at the edge of protein aggregation

(2015) N. Sanchez de Groot et al.   Open Biology

What Makes a Protein Sequence a Prion?

(2015) Raimon Sabate et al.   PLoS Computational Biology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Association Between Foldability and Aggregation Propensity in Small Disulfide-Rich Proteins

(2014) Hugo Fraga et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid Formation by Human Carboxypeptidase D Transthyretin-like Domain under Physiological Conditions

(2014) Javier Garcia-Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-phosphate Dehydrogenase

(2014) Andre L. Samson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome dysfunction induces muscle growth defects and protein aggregation

(2014) Y. Kitajima et al.   JOURNAL OF CELL SCIENCE

The yeast peroxiredoxin Tsa1 protects against protein-aggregate-induced oxidative stress

(2014) A. J. Weids et al.   JOURNAL OF CELL SCIENCE

Propensity to Form Amyloid Fibrils Is Encoded as Excitations in the Free Energy Landscape of Monomeric Proteins

(2014) Pavel I. Zhuravlev et al.   JOURNAL OF MOLECULAR BIOLOGY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Aggregation Prone Regions and Gatekeeping Residues in Protein Sequences

(2013) Jacinte Beerten et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

(2013) Emanuele D’Amico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-enzymatic glycation and glycoxidation protein products in foods and diseases: An interconnected, complex scenario fully open to innovative proteomic studies

(2013) Simona Arena et al.   MASS SPECTROMETRY REVIEWS

Redox Control of 20S Proteasome Gating

(2012) Gustavo M. Silva et al.   ANTIOXIDANTS & REDOX SIGNALING

Cysteine Reactivity Distinguishes Redox Sensing by the Heat-Inducible and Constitutive Forms of Heat Shock Protein 70

(2012) Yoshinari Miyata et al.   CHEMISTRY & BIOLOGY

Carbonylation of the cytoskeletal protein actin leads to aggregate formation

(2012) Jose Pedro Castro et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson’s disease

(2010) Donald M. Kuhn et al.   JOURNAL OF NEUROCHEMISTRY

Proteasome inhibition in medaka brain induces the features of Parkinson’s disease

(2010) Hideaki Matsui et al.   JOURNAL OF NEUROCHEMISTRY

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Ribosome-associated peroxiredoxins suppress oxidative stress-induced de novo formation of the [PSI+] prion in yeast

(2010) T. C. Sideri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

(2010) Yun-An Lim et al.   PROTEOMICS

Aβ40, either Soluble or Aggregated, Is a Remarkably Potent Antioxidant in Cell-Free Oxidative Systems

(2009) Rozena Baruch-Suchodolsky et al.   BIOCHEMISTRY

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

S-Glutathionylation of the Rpn2 Regulatory Subunit Inhibits 26 S Proteasomal Function

(2009) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death

(2009) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Amyloid β1−28−Copper(I)/Copper(II)/Iron(II) Complexes Are Potent Antioxidants in Cell-Free Systems

(2008) Rozena Baruch-Suchodolsky et al.   BIOCHEMISTRY

A model for the aggregation of the acylphosphatase from Sulfolobus solfataricus in its native-like state

(2008) Francesco Bemporad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome

(2008) Gustavo M. Silva et al.   FEBS Journal

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES