Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling

(2018) Li Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence

(2018) Hui Ling Ren et al.   MEDICAL SCIENCE MONITOR

Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells

(2018) W.S. Daniel Tan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop

(2017) Yang Wang et al.   Cell Death & Disease

Influence of age on pain intensity, functional impairment and health-related quality of life before and after surgery for lumbar degenerative disc disease

(2016) Oliver P. Gautschi et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Mammalian autophagy and the plasma membrane

(2016) Mariana Pavel et al.   FEBS Journal

Molecular mechanisms of biological aging in intervertebral discs

(2016) Nam V. Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The autophagy pathway maintained signaling crosstalk with the Keap1–Nrf2 system through p62 in auditory cells under oxidative stress

(2015) Ken Hayashi et al.   CELLULAR SIGNALLING

Autophagy in the Degenerating Human Intervertebral Disc

(2015) Helen E. Gruber et al.   SPINE

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

(2014) Gang Hou et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism

(2014) Libo Jiang et al.   CONNECTIVE TISSUE RESEARCH

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

The effects of microenvironment in mesenchymal stem cell–based regeneration of intervertebral disc

(2013) Yong-Can Huang et al.   Spine Journal

Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice

(2012) Ryo Ohta et al.   EUROPEAN SPINE JOURNAL

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc

(2008) Chun-Yuh Huang et al.   JOURNAL OF BIOMECHANICS