Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway

Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

(2018) Seung Pil Yun et al.   Biomolecules & Therapeutics

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

(2018) Nava Zisapel   BRITISH JOURNAL OF PHARMACOLOGY

TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells

(2018) L.-B. Jiang et al.   OSTEOARTHRITIS AND CARTILAGE

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

(2018) Jian Chen et al.   Cell Death & Disease

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway

(2017) Zheng Li et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy

(2017) Aparna Areti et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

(2017) Mingming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Rapid modulation of the silent information regulator 1 by melatonin after hypoxia-ischemia in the neonatal rat brain

(2017) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway

(2017) Haosen Zhao et al.   NEUROSCIENCE

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

(2017) M. Ito et al.   OSTEOARTHRITIS AND CARTILAGE

Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

(2017) Ke Chen et al.   Oxidative Medicine and Cellular Longevity

Economic evaluation of an implementation strategy for the management of low back pain in general practice

(2017) Cathrine Elgaard Jensen et al.   PAIN

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Oxidative damage induces apoptosis and promotes calcification in disc cartilage endplate cell through ROS/MAPK/NF-κB pathway: Implications for disc degeneration

(2017) Yingchao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol attenuated TNF-α–induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway

(2016) Xiao-Hu Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc

(2016) Qiaoqiao Zhu et al.   SPINE

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

(2016) C De Ford et al.   Cell Death & Disease

High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells

(2016) Xiaofei Cheng et al.   Journal of Diabetes Research

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

(2016) Caitlin O'Rourke et al.   Jove-Journal of Visualized Experiments

Atg5 siRNA inhibits autophagy and enhances norcantharidin-induced apoptosis in hepatocellular carcinoma

(2015) XUANXUAN XIONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress

(2015) Huikyong Lee et al.   MOLECULAR NEUROBIOLOGY

Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells

(2015) J. Fekadu et al.   MOLECULAR NEUROBIOLOGY

Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

(2015) Shingo Miyazaki et al.   ARTHRITIS RESEARCH & THERAPY

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

(2014) Chinmoy Sarkar et al.   Autophagy

Running on time: the role of circadian clocks in the musculoskeletal system

(2014) Michal Dudek et al.   BIOCHEMICAL JOURNAL

Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification

(2014) Hong-guang Xu et al.   BONE

Sleep disturbances predict long-term changes in low back pain among Finnish firefighters: 13-year follow-up study

(2014) Sirpa Lusa et al.   INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

Ectopic calcification in β-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation

(2013) Federica Boraldi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells

(2013) Eun-Young Park et al.   INTERNATIONAL ORTHOPAEDICS

The evidence and the possible significance of autophagy in degeneration model of human cervical end-plate cartilage

(2013) HONGGUANG XU et al.   Experimental and Therapeutic Medicine

SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway

(2012) DaWu Wang et al.   AGE

Immunohistochemical analysis of macroautophagy

(2012) Wim Martinet et al.   Autophagy

Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies

(2011) Francesco P. Cappuccio et al.   EUROPEAN HEART JOURNAL

Occupational loading, health behavior and sleep disturbance as predictors of low-back pain

(2011) Helena Miranda et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Sleep duration and mortality: a systematic review and meta-analysis

(2009) LISA GALLICCHIO et al.   JOURNAL OF SLEEP RESEARCH

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

(2008) Sudharsan Periyasamy-Thandavan et al.   KIDNEY INTERNATIONAL

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS

Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis

(2008) Khadidja Haidara et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY