Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes

Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis

(2021) Xingzhi Jing et al.   Frontiers in Cell and Developmental Biology

The detrimental effect of iron on OA chondrocytes: Importance of pro‐inflammatory cytokines induced iron influx and oxidative stress

(2021) Xingzhi Jing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration

(2021) Xingzhi Jing et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The protective mechanism of resveratrol against hepatic injury induced by iron overload in mice

(2021) Jinghan Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Iron homeostasis and organismal aging

(2021) Rola S. Zeidan et al.   AGEING RESEARCH REVIEWS

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Intervertebral Disc Degeneration is Associated with Aberrant Endplate Remodeling and Reduced Small Molecule Transport

(2020) Beth G. Ashinsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chondrocyte ferroptosis contribute to the progression of osteoarthritis

(2020) Xudong Yao et al.   Journal of Orthopaedic Translation

Apoptotic bodies from endplate chondrocytes enhance the oxidative stress‐induced mineralization by regulating PPi metabolism

(2019) Feng‐Lai Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N-acetyl-l-cysteine protects dental tissue stem cells against oxidative stress in vitro

(2018) Jasmina Martacic et al.   Clinical Oral Investigations

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Icariin protects against iron overload-induced bone loss via suppressing oxidative stress

(2018) Xingzhi Jing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intervertebral Disk Degeneration and Repair

(2017) James Dowdell et al.   NEUROSURGERY

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss

(2017) Viktória Jeney   Frontiers in Pharmacology

The relationship between Modic changes and intervertebral disc degeneration

(2016) Juhani H. Määttä et al.   BMC MUSCULOSKELETAL DISORDERS

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Iron Homeostasis in Health and Disease

(2016) Raffaella Gozzelino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

(2015) Lize F D van Vulpen et al.   JOURNAL OF CLINICAL PATHOLOGY

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study

(2014) Lauren Kennish et al.   BMC MUSCULOSKELETAL DISORDERS

Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons

(2013) Jia Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

(2012) Beom-Jun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Spine in β-Thalassemia Syndromes

(2011) Rachid Haidar et al.   SPINE

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Bone disease and skeletal complications in patients with β thalassemia major

(2010) Rachid Haidar et al.   BONE

Endplate degeneration may be the origination of the vacuum phenomenon in intervertebral discs

(2010) Fang-Cai Li et al.   MEDICAL HYPOTHESES

Risk Factors for Lumbar Intervertebral Disc Herniation in Chinese Population

(2009) Yin-gang Zhang et al.   SPINE