Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

(2016) Sung Min Son et al.   JOURNAL OF ALZHEIMERS DISEASE

The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

(2016) C De Ford et al.   Cell Death & Disease

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

(2016) Jianzhong Li et al.   Scientific Reports

Autophagy in the Degenerating Human Intervertebral Disc

(2015) Helen E. Gruber et al.   SPINE

Stimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury

(2015) Kai-liang Zhou et al.   Scientific Reports

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a

(2014) Amelie Boquoi et al.   AGING CELL

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification

(2014) Hong-guang Xu et al.   BONE

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Responses of Autophagy and Apoptosis to Oxidative Stress in Nucleus Pulposus Cells: Implications for Disc Degeneration

(2014) Jiang-Wei Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma

(2013) In-Ja Park et al.   APOPTOSIS

Cell death in intervertebral disc degeneration

(2013) Fan Ding et al.   APOPTOSIS

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity

(2013) Debapriya Dutta et al.   Autophagy

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway

(2012) DaWu Wang et al.   AGE

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

(2012) Libo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

The Effect of Injection Volume on Disc Degeneration in a Rat Tail Model

(2011) Hua-jie Mao et al.   SPINE

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

(2008) Bin Han et al.   SPINE