GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Authors
Keywords
-
Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1878, Issue 3, Pages 188890
Publisher
Elsevier BV
Online
2023-03-29
DOI
10.1016/j.bbcan.2023.188890
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- p53 in ferroptosis regulation: the new weapon for the old guardian
- (2022) Yanqing Liu et al. CELL DEATH AND DIFFERENTIATION
- Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4
- (2022) Wen Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4
- (2022) Zhengquan Xu et al. FREE RADICAL RESEARCH
- RNA-Seq Explores the Mechanism of Oxygen-Boosted Sonodynamic Therapy Based on All-in-One Nanobubbles to Enhance Ferroptosis for the Treatment of HCC
- (2022) Yichi Chen et al. International Journal of Nanomedicine
- Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
- (2022) Ruozhi Dang et al. Journal of Neuroinflammation
- Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma
- (2022) Huibin Song et al. Molecular Cancer
- Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis
- (2022) Hanzhi Ling et al. RHEUMATOLOGY
- Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis
- (2022) Yiting Wan et al. Scientific Reports
- GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis
- (2022) Shali Yu et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling
- (2022) Zhenzhou Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases
- (2022) Sina Shadfar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tumor Microenvironment-Responsive Nanodrug for Clear-Cell Renal Cell Carcinoma Therapy via Triggering Waterfall-Like Cascade Ferroptosis
- (2022) Wenjun Ni et al. Journal of Biomedical Nanotechnology
- Function and regulation of GPX4 in the development and progression of fibrotic disease
- (2022) Zhaobing Li et al. JOURNAL OF CELLULAR PHYSIOLOGY
- RXRγ attenuates cerebral ischemia–reperfusion induced ferroptosis in neurons in mice through transcriptionally promoting the expression of GPX4
- (2022) Lei Yang et al. METABOLIC BRAIN DISEASE
- HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis
- (2022) Youwen Tan et al. Cell Death & Disease
- Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases
- (2022) Can Cui et al. Frontiers in Molecular Biosciences
- NVP-AUY922 alleviates radiation-induced lung injury via inhibition of autophagy-dependent ferroptosis
- (2022) Li Li et al. Cell Death Discovery
- GPX4: old lessons, new features
- (2022) Thamara Nishida Xavier da Silva et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- METTL16 epigenetically enhances GPX4 expression via m6A modification to promote breast cancer progression by inhibiting ferroptosis
- (2022) Feng Ye et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease
- (2022) Lai-Hua Xie et al. Cells
- Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma
- (2022) Chao-Yu Liu et al. Scientific Reports
- Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer
- (2021) Ali Ghoochani et al. CANCER RESEARCH
- Cellular degradation systems in ferroptosis
- (2021) Xin Chen et al. CELL DEATH AND DIFFERENTIATION
- Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells
- (2021) Yahui Ding et al. Journal of Hematology & Oncology
- Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT
- (2021) Yongquan Bai et al. MOLECULES
- Ferroptosis: mechanisms, biology and role in disease
- (2021) Xuejun Jiang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
- (2021) Chuan’ai Chen et al. Cell Death & Disease
- The dark side of ferroptosis in pancreatic cancer
- (2021) Jiao Liu et al. OncoImmunology
- Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer
- (2021) Yifeng Hou et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Thioredoxin-1 Rescues MPP+/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4
- (2021) Liping Bai et al. MOLECULAR NEUROBIOLOGY
- mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
- (2021) Yilei Zhang et al. Nature Communications
- miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549
- (2021) Shi-hua Deng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma
- (2021) Zhixian Wang et al. ONCOLOGY REPORTS
- GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
- (2021) Qiujie Wang et al. Cell Death & Disease
- Ferroptosis, radiotherapy, and combination therapeutic strategies
- (2021) Guang Lei et al. Protein & Cell
- Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer
- (2021) Wenkuan Chen et al. Aging-US
- ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells
- (2021) Xiao Han et al. BREAST CANCER RESEARCH AND TREATMENT
- Histone H3K4me1 and H3K27ac play roles in nucleosome eviction and eRNA transcription, respectively, at enhancers
- (2021) Yujin Kang et al. FASEB JOURNAL
- Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis
- (2021) Yaqing Zhou et al. FREE RADICAL BIOLOGY AND MEDICINE
- Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells—“utilization” of ferroptosis mechanism
- (2021) Dingxi Li et al. INFLAMMATION RESEARCH
- Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy
- (2021) Jie Yang et al. JOURNAL OF CONTROLLED RELEASE
- Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
- (2021) Pengchong Li et al. NATURE IMMUNOLOGY
- Novel function of fluvastatin in attenuating oxidized low‑density lipoprotein‑induced endothelial cell ferroptosis in a glutathione peroxidase4‑ and cystine‑glutamate antiporter‑dependent manner
- (2021) Qing Li et al. Experimental and Therapeutic Medicine
- Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
- (2021) Wulf Tonnus et al. Nature Communications
- Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4
- (2021) Guan-Nan He et al. Drug Design Development and Therapy
- Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice
- (2021) Liuji Chen et al. Scientific Reports
- The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
- (2021) Chengxian Xu et al. Cell Reports
- CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells
- (2021) Wang Shanshan et al. Frontiers in Genetics
- Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?
- (2021) Jia-Yue Duan et al. Frontiers in Cell and Developmental Biology
- miR-135b-3p Promotes Cardiomyocyte Ferroptosis by Targeting GPX4 and Aggravates Myocardial Ischemia/Reperfusion Injury
- (2021) Weixin Sun et al. Frontiers in Cardiovascular Medicine
- PPAR-α Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer’s Diseases
- (2021) Xiao-Xia Qu et al. ACS Chemical Neuroscience
- Ketamine suppresses proliferation and induces ferroptosis and apoptosis of breast cancer cells by targeting KAT5/GPX4 axis
- (2021) Huixin Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction
- (2021) Mengxin Li et al. BIOCHEMICAL PHARMACOLOGY
- Targeted therapy for drug-tolerant persister cells after imatinib treatment for gastrointestinal stromal tumours
- (2021) Tomo Ishida et al. BRITISH JOURNAL OF CANCER
- KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma
- (2021) Yingqiang Lu et al. CANCER LETTERS
- Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway
- (2021) Siyu Yuan et al. CELL PROLIFERATION
- The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction
- (2021) Kai Fan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4
- (2021) Zixin Zhu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination
- (2021) Jingfa Zhang et al. EXPERIMENTAL CELL RESEARCH
- MiR‐15a‐3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer
- (2021) Liurong Liu et al. MOLECULAR CARCINOGENESIS
- Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
- (2021) Xinye Li et al. Oxidative Medicine and Cellular Longevity
- Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells
- (2021) Yi Luo et al. Oxidative Medicine and Cellular Longevity
- Metal‐Polyphenol‐Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification
- (2021) Lulu Zhou et al. Small
- Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells
- (2021) Yadong Sun et al. Cell Death & Disease
- Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis
- (2021) Shujun Xu et al. Bioengineered
- Prognostic and Immunological Role of Key Genes of Ferroptosis in Pan-Cancer
- (2021) Zhi-Zhou Shi et al. Frontiers in Cell and Developmental Biology
- Esophageal Cancer Stem-like Cells Resist Ferroptosis-Induced Cell Death by Active Hsp27-GPX4 Pathway
- (2021) Chen-Chi Liu et al. Biomolecules
- miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE
- (2021) Yan Yang et al. Cell Death Discovery
- Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
- (2020) Ling F. Ye et al. ACS Chemical Biology
- Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis
- (2020) Naoya Yamada et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
- (2020) Yanwei Su et al. CANCER LETTERS
- Broad domains of histone H3 lysine 4 trimethylation in transcriptional regulation and disease
- (2020) Shinae Park et al. FEBS Journal
- Ferroptosis-driven nanotherapeutics for cancer treatment
- (2020) Xinzhu Shan et al. JOURNAL OF CONTROLLED RELEASE
- Ferroptosis: past, present and future
- (2020) Jie Li et al. Cell Death & Disease
- Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis
- (2020) Azhaar Ashraf et al. Redox Biology
- Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy
- (2020) Yunpeng Wei et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis
- (2020) Yingying Yu et al. BLOOD
- Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
- (2020) John K. Eaton et al. Nature Chemical Biology
- TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells
- (2020) Do Hyung Kim et al. Cell Death & Disease
- The emerging role of ferroptosis in inflammation
- (2020) Yitian Sun et al. BIOMEDICINE & PHARMACOTHERAPY
- Ferroptosis in Liver Diseases: An Overview
- (2020) Martina Maria Capelletti et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Involvement of GPX4 in irisin's protection against ischemia reperfusion‐induced acute kidney injury
- (2020) Jia Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
- (2020) Rong Tang et al. Journal of Hematology & Oncology
- Redox homeostasis maintained by GPX4 facilitates STING activation
- (2020) Mutian Jia et al. NATURE IMMUNOLOGY
- The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine
- (2020) Paulina Wigner et al. Genes
- Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells
- (2020) Li Yang et al. Frontiers in Oncology
- Quercetin alleviates acute kidney injury by inhibiting ferroptosis
- (2020) Yue Wang et al. Journal of Advanced Research
- Ferroptosis: machinery and regulation
- (2020) Xin Chen et al. Autophagy
- KRAS: From undruggable to a druggable Cancer Target
- (2020) Dipesh Uprety et al. CANCER TREATMENT REVIEWS
- CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR‐541‐3p/GPX4 axis
- (2020) Qinhong Xu et al. CELL BIOLOGY INTERNATIONAL
- Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia‐reperfusion
- (2020) Yixin Xu et al. FASEB JOURNAL
- Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11
- (2020) Zhuanzhuan Qiang et al. Oxidative Medicine and Cellular Longevity
- Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC
- (2020) Siwei Qian et al. Frontiers in Oncology
- Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling
- (2020) Wenjun Yang et al. Aging-US
- Structure–activity relationships of GPX4 inhibitor warheads
- (2020) John K. Eaton et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
- (2020) Cadiele Oliana Reichert et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
- (2020) Nobuaki Takahashi et al. MOLECULAR CELL
- Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
- (2020) Enyong Dai et al. Nature Communications
- Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib
- (2020) Xiang Song et al. Frontiers in Oncology
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
- (2019) Matthew Dodson et al. Redox Biology
- Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review
- (2019) Pengxu Lei et al. Frontiers in Physiology
- Ferroptosis is a type of autophagy-dependent cell death
- (2019) Borong Zhou et al. SEMINARS IN CANCER BIOLOGY
- Chaperone-mediated autophagy is involved in the execution of ferroptosis
- (2019) Zheming Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Ferroptosis to Iron Out Cancer
- (2019) Behrouz Hassannia et al. CANCER CELL
- Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
- (2019) Ishraq Alim et al. CELL
- The molecular machinery of regulated cell death
- (2019) Daolin Tang et al. CELL RESEARCH
- Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
- (2019) Yufei Wang et al. EMBO REPORTS
- Molecular mechanisms of ferroptosis and its role in cancer therapy
- (2019) Tao Xu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
- (2019) Jiao Wu et al. NATURE
- Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis
- (2019) Shinya Tsurusaki et al. Cell Death & Disease
- A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
- (2019) Yilong Zou et al. Nature Communications
- Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin
- (2019) Xuefei Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- (2019) Yibing Chen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε
- (2019) Ana‐Marija Vučković et al. FEBS LETTERS
- Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators
- (2019) Kajarabille et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation
- (2019) Xueying Guan et al. LIFE SCIENCES
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
- (2019) Lian-Jiu Su et al. Oxidative Medicine and Cellular Longevity
- Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
- (2019) Tae-Jun Park et al. Cell Death & Disease
- Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice
- (2019) Jing Qi et al. AMERICAN JOURNAL OF PATHOLOGY
- Regulatory Phenomena in the Glutathione Peroxidase Superfamily
- (2019) Regina Brigelius-Flohé et al. ANTIOXIDANTS & REDOX SIGNALING
- Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels
- (2019) Yansheng Feng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy
- (2019) Min Gao et al. BIOMATERIALS
- Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress
- (2019) Wenyuan Li et al. DNA AND CELL BIOLOGY
- GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues
- (2018) Matilde Maiorino et al. ANTIOXIDANTS & REDOX SIGNALING
- Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy
- (2018) Hengrui Liu et al. BIOCHEMISTRY
- Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
- (2018) Astrid Borchert et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
- (2018) Michael J. Kerins et al. CANCER SCIENCE
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
- (2018) Irina Ingold et al. CELL
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- MicroRNA
- (2018) Thomas X. Lu et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Glutathione metabolism in cancer progression and treatment resistance
- (2018) Ankita Bansal et al. JOURNAL OF CELL BIOLOGY
- FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
- (2018) Michael M. Gaschler et al. Nature Chemical Biology
- ROS signalling in the biology of cancer
- (2018) Jennifer N. Moloney et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma
- (2018) Nataliya Rohr-Udilova et al. Oncotarget
- Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage
- (2018) Zhuwei Zhang et al. BRAIN RESEARCH
- Role of GPX4 in ferroptosis and its pharmacological implication
- (2018) Tobias M. Seibt et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer
- (2018) Daiha Shin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases
- (2018) Hao Chi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin protects against paraquat-induced damage during in vitro maturation of bovine oocytes
- (2018) Yun-Wei Pang et al. JOURNAL OF PINEAL RESEARCH
- Melatonin-induced demethylation of antioxidant genes increases antioxidant capacity through RORα in cumulus cells of prepubertal lambs
- (2018) Yi Fang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization
- (2017) Simona Pipolo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion
- (2017) Moritz Drefs et al. Oxidative Medicine and Cellular Longevity
- Gpx 4 is involved in the proliferation, migration and apoptosis of glioma cells
- (2017) Hongyu Zhao et al. PATHOLOGY RESEARCH AND PRACTICE
- ROS Are Good
- (2017) Ron Mittler TRENDS IN PLANT SCIENCE
- Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
- (2017) William Sealy Hambright et al. Redox Biology
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Mechanisms of ferroptosis
- (2016) Jennifer Yinuo Cao et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Glutathione peroxidase 4: a new player in neurodegeneration?
- (2016) B R Cardoso et al. MOLECULAR PSYCHIATRY
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
- (2016) Bradley A. Carlson et al. Redox Biology
- GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues
- (2015) E. Guerriero et al. EUROPEAN JOURNAL OF HISTOCHEMISTRY
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- (2015) Liuji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
- (2015) Mai Matsushita et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells
- (2015) Verónica Casañas-Sánchez et al. Frontiers in Physiology
- Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
- (2015) Lalage A. Katunga et al. Molecular Metabolism
- Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity
- (2015) Manuela Schneider et al. NEOPLASIA
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- ROS Function in Redox Signaling and Oxidative Stress
- (2014) Michael Schieber et al. CURRENT BIOLOGY
- Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity
- (2014) Charlène Brault et al. GUT
- Addition of docosahexaenoic acid, but not arachidonic acid, activates glutathione and thioredoxin antioxidant systems in murine hippocampal HT22 cells: potential implications in neuroprotection
- (2014) Verónica Casañas-Sánchez et al. JOURNAL OF NEUROCHEMISTRY
- Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
- (2014) Philipp Mertins et al. MOLECULAR & CELLULAR PROTEOMICS
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Polyunsaturated fatty acids and their metabolites in brain function and disease
- (2014) Richard P. Bazinet et al. NATURE REVIEWS NEUROSCIENCE
- Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing
- (2014) J H Song et al. ONCOGENE
- Hydrogen peroxide sensing, signaling and regulation of transcription factors
- (2014) H. Susana Marinho et al. Redox Biology
- Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice
- (2013) Markus Wortmann et al. CIRCULATION RESEARCH
- Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4
- (2013) David N. Hauser et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mapping of the N-Linked Glycoproteome of Human Spermatozoa
- (2013) Gaigai Wang et al. JOURNAL OF PROTEOME RESEARCH
- Role of Glutathione in Cancer Progression and Chemoresistance
- (2013) Nicola Traverso et al. Oxidative Medicine and Cellular Longevity
- The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
- (2012) Jan Lewerenz et al. ANTIOXIDANTS & REDOX SIGNALING
- Glutathione synthesis
- (2012) Shelly C. Lu BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Cancer Epigenetics: From Mechanism to Therapy
- (2012) Mark A. Dawson et al. CELL
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma
- (2011) Nataliya Rohr-Udilova et al. HEPATOLOGY
- The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization
- (2011) Rossella Puglisi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain
- (2011) Frederick P Bellinger et al. Molecular Neurodegeneration
- Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease
- (2009) Min-Hyuk Yoo et al. ANTIOXIDANTS & REDOX SIGNALING
- Glutathione peroxidases in different stages of carcinogenesis
- (2009) Regina Brigelius-Flohé et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions
- (2009) Hanyu Liang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
- (2008) Alexander Seiler et al. Cell Metabolism
- Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunction
- (2008) Erinne R. Dabkowski et al. FREE RADICAL BIOLOGY AND MEDICINE
- Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development
- (2008) C. Ufer et al. GENES & DEVELOPMENT
- DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma
- (2008) D F Peng et al. GUT
- Lipid peroxidation up-regulates BACE1 expressionin vivo: a possible early event of amyloidogenesis in Alzheimer’s disease
- (2008) Liuji Chen et al. JOURNAL OF NEUROCHEMISTRY
- Glutathione: Overview of its protective roles, measurement, and biosynthesis
- (2008) Henry Jay Forman et al. MOLECULAR ASPECTS OF MEDICINE
- Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice
- (2007) ZhongMao Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started