Article
Gastroenterology & Hepatology
Junyan Yan, Baowei Hu, Wenjie Shi, Xiaoyi Wang, Jiayuan Shen, Yaping Chen, Huarong Huang, Lifang Jin
Summary: In this study, Gli2 was shown to regulate HSC activation and liver fibrosis through TGF-beta signaling. Conditional deletion of Gli2 in HSCs reduced liver fibrosis and HSC activation in a mouse model. Additionally, Gli2 promoted HSC activation by upregulating cyclin expression and TGF-beta signaling activity. These findings support further research on Gli2 inhibition as a potential therapy for slowing liver fibrosis progression in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Article
Biochemistry & Molecular Biology
Ji Hye Yang, Sae Kwang Ku, Il Je Cho, Je Hyeon Lee, Chang-Su Na, Sung Hwan Ki
Summary: Neoagarooligosaccharides (NAOs) have protective effects against hepatic fibrosis and inhibit the TGF-beta/Smad signaling pathway. This was validated in in vitro experiments and mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hanglu Ying, Long Li, Yufen Zhao, Feng Ni
Summary: This study evaluated the function of ivermectin in regulating liver fibrosis. The results showed that ivermectin alleviated histopathological changes, improved liver function, reduced collagen deposition, and downregulated the expression of profibrotic genes. Mechanistically, it inhibited intrahepatic macrophage accumulation and suppressed the production of proinflammatory factors. Importantly, it also promoted HSC deactivation by reducing the protein levels of alpha-smooth muscle actin (alpha-SMA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu
Summary: Hepatic fibrosis is a stage of chronic liver disease that can lead to cirrhosis or liver cancer. The activation of hepatic stellate cells (HSCs) is a crucial event in fibrosis development and inhibiting this activation has been shown to alleviate fibrosis. Roxarsone, an organoarsenic additive used in livestock production, has been found to inhibit HSC activation and improve liver function in a mouse model of fibrosis. These findings suggest that Roxarsone could be a potential treatment for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Jun Ho Lee, Joan Massague
Summary: TGF-beta plays a crucial role in development, wound healing, fibrosis, and cancer by inducing epithelial-mesenchymal transitions (EMTs). EMTs are regulated by multiple signaling inputs, with RAS-MAPK signaling frequently required for EMT induction by TGF-beta. Recent studies have revealed the molecular basis for the cooperation between the TGF-beta-SMAD and RAS-MAPK pathways in EMT induction, offering insights into EMT and progenitor cell differentiation during gastrulation and cancer metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang You, Chongqing Gao, Junru Wu, Hengdong Qu, Yang Xiao, Ziwei Kang, Jinying Li, Jian Hong
Summary: ARK5 plays a critical role in liver fibrosis by maintaining the continuous transduction of the TGF-beta signaling pathway in HSCs and inducing epithelial-mesenchymal transition and inflammatory factor secretion in hepatocytes, thereby promoting liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Taixiong Xue, Lin Yue, Guonian Zhu, Zui Tan, Hongyao Liu, Cailing Gan, Chen Fan, Xingping Su, Yuting Xie, Tinghong Ye
Summary: In this study, a phenylacrylic acid derivative, FA11, was synthesized and found to have excellent antifibrotic activity, making it a potential candidate for the treatment of liver fibrosis.
LIVER INTERNATIONAL
(2023)
Review
Oncology
Valeria Ramundo, Giuliana Giribaldi, Elisabetta Aldieri
Summary: Metabolic changes in the tumor microenvironment play a critical role in cancer by affecting signaling pathways that control cellular metabolism. The deregulation of cancer metabolism is closely related to oxidative stress control and the involvement of cytokines like transforming growth factor beta (TGF-beta) in tumorigenesis and cancer progression. The crosstalk between TGF-beta and oxidative stress contributes significantly to tumorigenesis and cancer invasiveness by affecting redox imbalance and cellular metabolism.
Article
Biochemistry & Molecular Biology
Chan Qiu, Yi Liu, Shengjie Huang, Bo Ning, Song He, Li Zhong
Summary: Our study demonstrated that Rab31 could promote hepatic stellate cells activation by accelerating TGF-beta Receptor II complex endocytosis, suggesting that interfering with Rab31 could be an effective strategy to inhibit hepatic fibrosis progression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sam Seok Cho, Ji Hyun Lee, Kyu Min Kim, Eun Young Park, Sae Kwang Ku, Il Je Cho, Ji Hye Yang, Sung Hwan Ki
Summary: REDD1 plays a crucial role in inhibiting HSC activation and protecting against liver fibrosis by modulating the AP-1 and Smad signaling pathways induced by TGF-beta. Overexpression of REDD1 suppresses fibrogenic gene expression induced by TGF-beta and restores GSH and malondialdehyde levels, thus showing potential as a therapeutic target for liver fibrosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Liyan Shi, Xiuli Zhang, Xin Liu, Yunyao Jiang, Yongyan Deng, Junzhi Liu
Summary: Cranberry phytochemicals (CPS) can inhibit HSC activation and liver fibrosis by reducing the expression of inflammatory cytokines and inhibiting the TGF beta/Smad signaling pathway. In vitro studies have shown significant effects of CPS on HSCs, with promising therapeutic effects in a rat model of liver fibrosis.
Review
Gastroenterology & Hepatology
Leke Wiering, Pallavi Subramanian, Linda Hammerich
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a wide range of severity, from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma, making hepatic fibrosis an important predictor of outcomes. Recent advancements in understanding the activation and inactivation of hepatic stellate cells, which drive fibrosis development, have shed light on the disease progression in NAFLD/NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Yang Zhang, Yuan Wu, Wenjuan Shen, Bingyu Wang, Xingxing Yuan
Summary: Liver fibrosis is a common pathological process in chronic liver diseases, which can progress to irreversible cirrhosis and cancer. Hepatic stellate cells are activated and produce collagen in response to liver injury, triggering the initiation and progression of fibrosis. Natural killer cells, as a key component of hepatic innate immunity, can alleviate fibrosis by killing activated hepatic stellate cells. Current antifibrotic interventions have improved fibrosis, but cannot halt its progression in the advanced stage. Understanding the interaction between natural killer cells and hepatic stellate cells may provide clues for the pathogenesis and potential therapies for advanced liver fibrosis.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Multidisciplinary Sciences
Xiongqun Peng, Huixiang Yang, Lijian Tao, Jingni Xiao, Ya Zeng, Yueming Shen, Xueke Yu, Fei Zhu, Jiao Qin
Summary: This study investigated the therapeutic effect of the antifibrotic drug fluorofenidone on liver fibrosis and its mechanism. The results showed that fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the involvement of SMAD2/SMAD3 and autophagy.
Article
Chemistry, Applied
Jinqiang Zhou, Bidong Wu, Miao Wang, Shujie Liu, Zhanxiong Xie, Chongwei An, Jingyu Wang
Summary: An effective method for preparing energetic microspheres by fluid-focusing microchannels is proposed, which combines the advantages of low reagent consumption, instrument miniaturization, accurate control, and efficient heat mass transfer. Compared with traditional water-suspension method, the microspheres prepared by the droplet microfluidic method show better morphology, particle size uniformity, and monodispersity. In addition, the fluidity and bulk density of the microspheres are significantly improved.
JOURNAL OF ENERGETIC MATERIALS
(2023)
Article
Chemistry, Applied
Wangjian Cheng, Kun Li, Lilong Gao, Chenhe Feng, Chongwei An, BaoYun Ye, Jingyu Wang
Summary: This study analyzed the distribution characteristics of the main explosive with different particle sizes and gradations using fractal theory and explored the effect of the gradation on the slurry. The results showed that particle size gradation can improve the fractal dimension of the explosive and reduce the thixotropic loop area of the slurry by increasing temperature and particle size distribution.
JOURNAL OF ENERGETIC MATERIALS
(2023)
Article
Agriculture, Dairy & Animal Science
Xian Liu, Peng Yang, Haoming Sun, Zijing Zhang, Cuicui Cai, Jiawei Xu, Xiaoting Ding, Xianwei Wang, Shijie Lyu, Zhiming Li, Zejun Xu, Qiaoting Shi, Eryao Wang, Chuzhao Lei, Hong Chen, Baorui Ru, Yongzhen Huang
Summary: This study found an association between copy number variation of the VAMP7 gene and growth traits in cattle. In Yunling cattle, the Duplication type of the gene was significantly related to height at the hip cross, with individuals having this type showing poorer growth and development. Individuals with other CNV types may be considered for breeding purposes.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lixian Zou, Yuan Zheng, Jialing Chen, Yu Ding, Hui Liu, Yubao Liu, Jian Xu, Hairong Zheng, Xin Liu
Summary: Autocalibrated MB + CS-FPP improves the anatomical coverage of myocardial perfusion imaging while maintaining comparable image quality to conventional FPP. This is of great significance for the diagnosis of coronary artery disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Automation & Control Systems
Jianlin Wang, Xinquan Zhang
Summary: This article studies the problem of overcoming controller vulnerability in nonlinear continuous-time switched systems with saturating actuators. The sufficient condition for non-fragile stabilization of the system is derived using multiple Lyapunov functions. Then, a switching law and non-fragile state feedback controllers are designed to achieve asymptotic stabilization of the closed-loop system at the origin. Finally, the design issue of the controllers and switching law is transformed into a convex optimization problem with linear matrix inequalities (LMI) constraints, and a numerical example is provided to verify the effectiveness of the proposed method.
JOURNAL OF CONTROL AND DECISION
(2023)
Article
Clinical Neurology
Weilong Guo, Jin Liu, Bangshan Liu, Mi Wang, Qiangli Dong, Xiaowen Lu, Jinrong Sun, Liang Zhang, Hua Guo, Futao Zhao, Weihui Li, Zexuan Li, Mei Liao, Li Zhang, Yan Zhang, Yumeng Ju, Lingjiang Li
Summary: This study examines the impact of childhood maltreatment and major depressive disorder (MDD) on cognitive function in unmedicated patients. MDD significantly impairs cognitive function in all domains, while childhood maltreatment only affects memory. No interactive effect was found between MDD and childhood maltreatment.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Tingting Chai, Jiahui Li, Yanhong Wang, Guoying Sun, Changyong Guo, Zhaoxin Zhang
Summary: Finger-vein has been widely used in automatic personal recognition systems. This study investigates lightweight CNN models and the effect of image enhancement on finger-vein biometrics. Transfer learning plays an important role in extracting informative features. The experimental results show that the proposed lightweight model outperforms existing competition winners and image enhancement is not essential for CNN-based finger-vein biometrics.
NEURAL PROCESSING LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Jia-yun Ni, Xin Wang, Hong-yan Xie, Ning-hao Yang, Jing-yao Li, Xi-ang Sun, Heng-jiang Guo, Li Zhou, Wei Zhang, Jun Liu, Li-min Lu
Summary: Transforming growth factor-beta 1 (TGF-beta 1) plays a key role in promoting renal fibrosis during chronic kidney disease (CKD). Cellular senescence is associated with CKD progression, and accelerated tubular cell senescence contributes to renal fibrosis. The elevation of Usp11 under pathological condition is implicated in promoting renal fibrosis by deubiquitinating Tgfbr2, reducing its degradation, and facilitating downstream senescent signaling pathway activation.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Engineering, Environmental
Jiaqin He, Xunxun Li, Yaru Wang, Jun Xiao, Yunchong Liu, Hua Li, Najun Li, Qingfeng Xu, Jinghui He, Dongyun Chen, Jianmei Lu
Summary: A facile and eco-friendly strategy was developed to synthesize a series of Au-modified hollow Ni-Mn spinel nanospheres decorated on graphene aerogels (termed Auy-hNixMn3_x/GAz) composite catalysts for deep catalytic oxidation of Volatile organic compounds (VOCs). The introduction of hollow structure led to a larger specific surface area and more accessible active sites. The subsequent cooperation of Au further strengthened the low-temperature reducibility along with more active surface oxygen species.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Li, Juan Zhang, Yu Shi, Horst Sievert, Cynthia C. Taub, Stefan Bertog, Shengjun Ta, Lei Changhui, Ethan Senser, Jing Wang, Rui Hu, Junzhe Huang, Fangqi Ruan, Yupeng Han, Xiaojuan Li, Bo Wang, Xueli Zhao, Jiao Liu, David H. Hsi, Liwen Liu
Summary: PIMSRA is an effective treatment option for hypertrophic obstructive cardiomyopathy (HOCM), leading to improved exercise capacity, reduced left ventricular outflow tract gradients, and increased myocardial contractile function.
Article
Chemistry, Organic
Lixia Ding, Zhifei Zhu, Xinyue Zhou, Gongming Zhu, Jian-Hua Wang, Shu-Tong Zhu, Bing Hu, Xiao-Na Wang, Junbiao Chang
Summary: We present two efficient intermolecular self-cycloadditions of N-aryl-substituted ynamides via metal-free approaches, resulting in the synthesis of valuable aminocyclobutenes and 4-aminoquinoline derivatives with good yields and wide substrate scope. Our modified method allowed for the effective preparation of terminal N-aryl ynamides, which then underwent thermally driven and solvent-free [2 + 2] cycloaddition to form functionalized aminocyclobutenes, or TMSOTf/TfOH-catalyzed [4 + 2] cycloaddition to produce 4-aminoquinoline derivatives. Furthermore, evaluation of their in vitro activity revealed that some of the cycloaddition products and their derivatives exhibited highly potent activities against SARS-CoV-2, DENV-2, and tumor cell lines.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Computer Science, Artificial Intelligence
Guangming Wang, Xinrui Wu, Shuyang Jiang, Zhe Liu, Hesheng Wang
Summary: This paper proposes an efficient 3D point cloud learning architecture called EfficientLO-Net for LiDAR odometry. It introduces the projection-aware representation of the 3D point cloud to achieve efficiency. The Pyramid, Warping, and Cost volume (PWC) structure is built to estimate and refine the pose. The architecture incorporates a projection-aware attentive cost volume, a trainable embedding mask, and a trainable pose warp-refinement module to improve the pose estimation and filter outlier points.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2023)
Article
Chemistry, Physical
Shuaishuai Shang, Shuhao An, He Li, Jianping Li, Shenping Zhang, Changjun Peng, Honglai Liu, Jun Hu
Summary: We developed a sulfonate-based covalent organic framework (sCOF) for the fast and sensitive detection of tetracycline hydrochloride (TCH). By incorporating disulfonic acid into COF, we achieved self-exfoliation of the framework and obtained fluorescent covalent organic nanosheets (f-sCON). These f-sCON nanosheets showed excellent sensitivity towards TCH residuals and could be used to create a naked-eye fluorescent device. Furthermore, by combining sulfonate-COF adsorbent and f-sCON-gel in a mixed column, we successfully achieved simultaneous TCH removal and detection.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Hematology
Lili Song, Peifeng Li, Huiying Sun, Lixia Ding, Jing Wang, Benshang Li, Bin-Bing S. Zhou, Haizhong Feng, Yanxin Li
Summary: This study found that mutations in phosphoribosyl pyrophosphate synthetase 2 (PRPS2) drive relapse of childhood acute lymphoblastic leukemia (ALL) by influencing the stability of PRPS1/2 hexamers. Mutations in PRPS2 decrease the effectiveness of thiopurine therapy in relapsed childhood ALL. This discovery provides important clues for finding biomarkers for relapsed ALL.
Article
Chemistry, Physical
Yanlin Feng, Jianlin Wang, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao, Xiaoyuan Chen, Jimin Cao
Summary: We developed a stable pyroelectric BaTiO3@Au core-shell nanostructure that can selectively block energy generation of tumor cells, providing a promising therapeutic approach for triple-negative breast cancer.