Article
Biochemistry & Molecular Biology
Inga Soerensen-Zender, Song Rong, Hermann Haller, Roland Schmitt
Summary: This study investigated the therapeutic potential of increasing AZGP1 in treating fibrotic kidney disease. Both systemic treatment with recombinant AZGP1 and conditional overexpression of AZGP1 in proximal tubular cells showed beneficial effects, including reduced collagen deposition and improved lipid metabolism in tubular cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Taghi Manshouri, Ivo Veletic, Ping Li, C. Cameron Yin, Sean M. Post, Srdan Verstovsek, Zeev Estrov
Summary: GF1 is highly expressed in BM fibrocytes of MF patients, affecting fibrocyte-induced BM fibrosis by influencing MMP levels, and STAT3-activated GLI1 is also involved in the fibrosis process.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Luan Gaviao Prado, Angela Silva Barbosa
Summary: Leptospirosis, caused by pathogenic species of the genus Leptospira, is a neglected infectious disease that can be diagnosed through serological and molecular methods. The chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection are significant topics of discussion, with many mechanisms still overlooked in understanding the chronic status of this infectious disease. Recent findings highlight cellular communication pathways and the relationship between renal fibrosis and CKD/CKDu caused by leptospirosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jian Zhou, Yuan Tan, Rurong Wang, Xuehan Li
Summary: This review summarizes the regulatory mechanism of ferroptosis and its roles in fibrotic diseases. Recent studies have suggested that ferroptosis may serve as an attractive therapeutic target for fibrotic diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Seoyeon Lee, Mohammad Naimul Islam, Kaveh Boostanpour, Dvir Aran, Guangchun Jin, Stephanie Christenson, Michael A. Matthay, Walter L. Eckalbar, Daryle J. DePianto, Joseph R. Arron, Liam Magee, Sunita Bhattacharya, Rei Matsumoto, Masaru Kubota, Donna L. Farber, Jahar Bhattacharya, Paul J. Wolters, Mallar Bhattacharya
Summary: Analysis of lung samples from healthy human donors reveals an increase in cellular senescence and pro-fibrotic pathway activation with age. Telomere shortening, decreased lung epithelial cells, and increased fibroblasts are associated with aging. This study shows a profile of increased vulnerability to lung diseases with age, highlighting the importance of genomic analysis and live lung imaging in understanding the natural history of human lung aging.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Bo Wang, Li-na Yang, Le-tian Yang, Yan Liang, Fan Guo, Ping Fu, Liang Ma
Summary: The natural flavonol fisetin has therapeutic effects against fibrotic kidney diseases by inhibiting ACS14-mediated tubular ferroptosis, alleviating inflammation and fibrogenesis, and protecting the kidneys from damage.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Xian He, Ming-Xi Zhou, Cheng Cheng, Shan-Shan Li, Yuan Gao, Zhi-Tao Ma, Xin-Hua Song, Zhao-Fang Bai, Zheng-Sheng Zou, Xiao-He Xiao, Jia-Bo Wang, Ya-Wen Lu
Summary: Metabolomic analysis identified characteristic metabolites associated with fibrosis in chronic drug-induced liver injury, with disturbance of lipid metabolites being highlighted as the primary factor in fibrosis development. The metabolomic fingerprints have potential clinical diagnostic and prognostic significance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Amy Hajari Case
Summary: Interstitial lung diseases (ILD) can have variable prognoses, but some exhibit fibrosis and progressive disease. Idiopathic pulmonary fibrosis is the most common type, but other ILDs, such as autoimmune ILD and chronic hypersensitivity pneumonitis, can also have a progressive fibrotic phenotype. The typical interstitial pneumonia pattern of lung involvement is a significant risk factor, suggesting shared fibrotic pathways that can be targeted by antifibrotic therapies. This review describes the most commonly fibrotic ILDs, shared risk factors for developing PF-ILD, and evidence for the use of antifibrotic therapies in their management.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Li Li, Meizhi He, Xiaoman Tang, Junxin Huang, Jing Li, Xue Hong, Haiyan Fu, Youhua Liu
Summary: The extracellular matrix (ECM) is a complex network of proteins that controls various cellular processes. In chronic kidney disease (CKD), the ECM undergoes changes that contribute to kidney fibrosis. Using proteomic analysis, this study identified differentially expressed proteins in the ECM of mice with CKD and found that 9 signature proteins are involved in the fibrogenic microenvironment. Furthermore, the depletion of glutathione peroxidase 3 (GPX3), one of the signature proteins, was shown to promote oxidative stress and kidney fibrosis. These findings highlight the importance of oxidative stress in the fibrogenic microenvironment.
KIDNEY INTERNATIONAL
(2023)
Article
Physics, Multidisciplinary
Farhad Pashakhanloo, Alexander V. Panfilov
Summary: Cardiac fibrosis is a well-known arrhythmogenic condition that can lead to sudden cardiac death. The concept of minimal functional cluster accurately characterizes the path of reexcitation and quantitatively predicts the reentry probability. Fibrosis density and tissue excitability affect the probability of reentry.
PHYSICAL REVIEW LETTERS
(2021)
Article
Critical Care Medicine
Mark P. Steele, Anna L. Peljto, Susan K. Mathai, Stephen Humphries, Tami J. Bang, Andrea Oh, Shawn Teague, Giuseppe Cicchetti, Christopher Sigakis, Jonathan A. Kropski, James E. Loyd, Timothy S. Blackwell, Kevin K. Brown, Marvin Schwarz, Rachel A. Warren, Julia Powers, Avram D. Walts, Cheryl Markin, Tasha E. Fingerlin, Ivana Yang, David A. Lynch, Joyce S. Lee, David A. Schwartz
Summary: Relatives of patients with FIP are at higher risk for developing PrePF, which has a much higher incidence rate compared to sporadic IPF. PrePF is progressive and associated with decreased survival.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Biology
Kristin Berger, Robert J. Kaner
Summary: Interstitial lung disease is a term that includes various lung pathologies affecting gas exchange. While many are not fibrotic, some can lead to pulmonary fibrosis and progression over time. Idiopathic pulmonary fibrosis is a progressive fibrotic disease with high mortality, emphasizing the importance of accurate and timely diagnosis for prognosis and clinical management. Consensus diagnosis requires a multidisciplinary team and may involve tissue sampling. The heterogeneity of disease behavior and lack of controlled trials make clinical management challenging. This review focuses on current paradigms and updates in diagnosis and pharmacologic management of fibrotic interstitial lung diseases.
Review
Biochemistry & Molecular Biology
Anna Valeria Samarelli, Roberto Tonelli, Alessandro Marchioni, Giulia Bruzzi, Filippo Gozzi, Dario Andrisani, Ivana Castaniere, Linda Manicardi, Antonio Moretti, Luca Tabbi, Stefania Cerri, Bianca Beghe, Massimo Dominici, Enrico Clini
Summary: This review discusses the pathogenic mechanisms leading to the onset and progression of different IIPs, starting from the most studied IPF, in order to identify common and standalone molecular and cellular key players. A deeper molecular and cellular characterization of various interstitial lung diseases with unknown causes would contribute to providing more accurate diagnoses for patients, leading to more effective treatment decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ziwei Xing, Chao Yang, Yaqian Feng, Junyao He, Cheng Peng, Dan Li
Summary: This study demonstrates the potential of aconite as an anti-fibrotic agent and elucidates its mechanism in reducing collagen deposition and alleviating metabolic disruptions in cardiac fibrosis via the galactose metabolism pathway.
Article
Medicine, Research & Experimental
Shinkyu Choi, Ji Aee Kim, Haiyan Li, Seong-Eun Jo, Huisu Lee, Tae Hun Kim, Minje Kim, Seong-Jin Kim, Suk Hyo Suh
Summary: The study demonstrated that modafinil attenuated inflammatory and fibrotic progression through K(Ca)2.3- and K(Ca)3.1-mediated pathways in nonalcoholic hepatitis, suggesting a novel therapeutic approach for inflammatory and fibrotic liver diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)