Article
Plant Sciences
Jian Ye, Tian-Jiao Lyu, Ling-Yan Li, Ying Liu, Hong Zhang, Xu Wang, Xin Xi, Zong-Jun Liu, Jun-Qing Gao
Summary: This study investigates the protective mechanism of Ginsenoside Re and the role of ferroptosis in myocardial ischemia/reperfusion injury. The findings suggest that Ginsenoside Re attenuates ferroptosis induced by myocardial ischemia/reperfusion through the miR-144-3p/SLC7A11 pathway, thereby reducing cardiac damage.
Article
Chemistry, Medicinal
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen, Jing Yan
Summary: This study aimed to investigate the pharmacological effects of Gal on myocardial ischemic reperfusion injury (MIRI). The results showed that Gal alleviates myocardial injury, enhances cardiac function, and reduces cell death by targeting the Nrf2/Gpx4 signaling pathway to prevent iron overload and lipid peroxidation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Endocrinology & Metabolism
Bingxuan Zheng, Yingcong Guo, Yuxi Qiao, Yang Li, Jin Zheng, Puxun Tian, Xiaoming Ding, Wujun Xue, Chenguang Ding
Summary: This study aimed to explore the role of ferroptosis in ischemia/reperfusion-induced acute kidney injury (AKI). Ferroptosis was observed in the renal tissue of IR rats, and miR-188-3p was found to promote ferroptosis in IR-associated AKI through downregulation of GPX4.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Biochemistry & Molecular Biology
Jolanta Laukaitiene, Greta Gujyte, Edmundas Kadusevicius
Summary: About 50 years ago, Eugene Braunwald, a father of modern cardiology, introduced the revolutionary belief that time is muscle, which has since driven efforts to protect the unaffected myocardium. However, understanding the metabolic changes in the ischemic myocardium after acute myocardial infarction (AMI) has proven challenging due to inconsistencies and dependencies on various factors. In recent years, the study of iron metabolism has emerged as a promising approach in the field of ischemic heart research, specifically focusing on a programmed cell death called ferroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Chaowen Ge, Yuqin Peng, Jiacheng Li, Lei Wang, Xiaoyu Zhu, Ning Wang, Dongmei Yang, Xian Zhou, Dennis Chang
Summary: This study investigated the protective effects of Hydroxysafflor yellow A (HSYA) against myocardial ischemia/reperfusion injury (MI/RI) and identified the underlying mechanisms. HSYA reduced myocardial histopathological damage, ameliorated mitochondrial damage, and decreased iron contents in myocardial tissue. It activated the HIF-1a/SLC7A11/GPX4 signaling pathway to inhibit ferroptosis, thereby alleviating MI/RI.
Article
Biochemistry & Molecular Biology
Liurong Liu, Huihui Yao, Xin Zhou, Junjie Chen, Guoliang Chen, Xinyu Shi, Guanting Wu, Guoqiang Zhou, Songbing He
Summary: miR-15a-3p positively regulates ferroptosis in CRC by targeting GPX4, leading to increased levels of reactive oxygen species and malondialdehyde accumulation with overexpression, while reducing sensitivity to erastin and GPX4 with suppression.
MOLECULAR CARCINOGENESIS
(2022)
Article
Chemistry, Medicinal
Guan-Nan He, Na-Ren Bao, Shuang Wang, Man Xi, Tian-Hao Zhang, Feng-Shou Chen
Summary: Ketamine was found to suppress liver cancer cell proliferation and induce ferroptosis, potentially through regulating the lncPVT1/miR-214-3p/GPX4 axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Yanan Li, Qianni Shen, Lidan Huang, Bingyu Li, Yuxi Zhang, Wei Wang, Bo Zhao, Wenwei Gao
Summary: This study investigates the role of GRSF1 in cerebral ischemia-reperfusion injury (CIRI) and its specific mechanisms. The researchers found that GRSF1 expression was low in CIR mice, while senescence-related markers were increased. Overexpression of GRSF1 improved infarct volume and neurological function, and suppressed apoptosis. The results suggest that cellular senescence contributes to CIRI, and GRSF1 can protect against reperfusion injury by regulating GPX4.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Huaying Wang, Shanshan Guo, Bingdian Wang, Xueqi Liu, Li Gao, Chaoyi Chen, Yonggui Wu
Summary: The study found that carnosine can alleviate acute kidney injury, inflammation and ferroptosis. Treatment with carnosine reduced lipid peroxidation and iron accumulation, suppressed oxidative stress, and inhibited ferroptosis. Furthermore, carnosine was shown to bind with GPX4, which is a potential target for its protective effects on kidney cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yu-Ting Wu, Guo-Yong Zhang, Yue Hua, Hui-Jie Fan, Xin Han, Hong-Lin Xu, Guang-Hong Chen, Bin Liu, Ling-Peng Xie, Ying-Chun Zhou
Summary: The study showed that Nrf2 signaling plays a critical role in regulating ferroptosis in cardiovascular disease, and ferrostatin-1 can improve this process. Deficiency or inhibition of Nrf2 exacerbated myocardial infarction-induced cardiomyocyte ferroptosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fan Deng, Bing-Cheng Zhao, Xiao Yang, Ze-Bin Lin, Qi-Shun Sun, Yi-Fan Wang, Zheng-Zheng Yan, Wei-Feng Liu, Cai Li, Jing-Juan Hu, Ke-Xuan Liu
Summary: Intestinal ischemia/reperfusion (I/R) injury disrupts gut microbiota and causes significant changes in metabolites, while capsiate (CAT), a gut microbiota metabolite, can alleviate ferroptosis-dependent intestinal I/R injury.
Article
Biochemistry & Molecular Biology
Ming Li, Jiarui Li, Hui Wu, Zhaoli Meng, Shichao Yu, Yupeng Wang, Wei Yang
Summary: This study investigated the potential role of baicalein in cerebral I/R injury and found that baicalein could improve cell viability and ameliorate cerebral I/R injury in mice. Further analysis revealed that baicalein inhibited ferroptosis by regulating the expression levels of GPX4, ACSL4, and ACSL3. These findings suggest that baicalein has therapeutic potential as a drug for cerebral I/R injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Plant Sciences
Rui Yu, Youfeng Zhou, Shufeng Shi, Xue Wang, Shuaishuai Huang, Yu Ren
Summary: The flavonoid Icariside II (ICS II) has been found to inhibit the proliferation, migration, and invasion of renal cell carcinoma (RCC) cells. This study demonstrated that ICS II induces a form of cell death called ferroptosis in RCC cells, which is accompanied by increased levels of Fe2+, MDA, and ROS, as well as decreased levels of GSH. The underlying mechanism involves the downregulation of GPX4 and the upregulation of miR-324-3p, which directly targets GPX4.
Article
Biochemistry & Molecular Biology
Yifeng Hou, Shuang Cai, Shouyang Yu, Hui Lin
Summary: Metformin induces ferroptosis in breast cancer cells by upregulating miR-324-3p, leading to decreased cancer cell viability. The drug promotes ferroptosis by targeting the miR-324-3p/GPX4 axis, suggesting its potential as an anti-cancer agent.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen Jin, Wei Duan, Xiu Liu, Yingying Liu, Shuai Huang, Yonghua Tuo, Fei Pei, Zhengyang Jian, Pengyu Zhou, Shaoyi Zheng, Zhaowei Zou, Feng Zhang, Quan Gong, Sijia Liang
Summary: TMEM16A exacerbates hepatic I/R injury by promoting GPX4-dependent ferroptosis. TMEM16A-GPX4 interaction and GPX4 ubiquitination are therefore indispensable for TMEM16A-regulated hepatic I/R injury.
CELL DEATH & DISEASE
(2022)