Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?

Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer

(2021) Ali Ghoochani et al.   CANCER RESEARCH

BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes

(2021) Ricardo Carnicer Hijazo et al.   CIRCULATION RESEARCH

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

(2021) Wen-Qi Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

(2021) Er-Fei Luo et al.   World Journal of Diabetes

HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

(2021) You Wu et al.   BIOSCIENCE REPORTS

Exosomes derived from vascular endothelial cells antagonize glucocorticoid‐induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts

(2021) Run‐Ze Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

(2021) Gai Gao et al.   Journal of Natural Medicines

Mini-Review: Is iron-mediated cell death (ferroptosis) an identical factor contributing to the pathogenesis of some neurodegenerative diseases?

(2021) Alena Viktorinova et al.   NEUROSCIENCE LETTERS

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

(2021) Seonghun Kim et al.   Cell Death & Disease

NUPR1 is a critical repressor of ferroptosis

(2021) Jiao Liu et al.   Nature Communications

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

(2021) Xinxin Song et al.   Cell Reports

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

Ferroptosis and Its Modulation by Autophagy in Light of the Pathogenesis of Lysosomal Storage Diseases

(2021) Karolina Pierzynowska et al.   Cells

Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis

(2021) Bing Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

(2021) Jianan Zhao et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Ferroptosis and its emerging roles in cardiovascular diseases

(2021) Ning Li et al.   PHARMACOLOGICAL RESEARCH

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis

(2021) Hongrong Ding et al.   Journal of Cachexia Sarcopenia and Muscle

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

(2021) Bastian Krümmel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells

(2020) Ariunaa Sampilvanjil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AIFM2 blocks ferroptosis independent of ubiquinol metabolism

(2020) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

(2020) Massimo M. Santoro   Cell Metabolism

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

(2020) Anastasia Poznyak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cells

(2020) Tao Bai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes

(2020) Chien-Chang Ho et al.   Journal of the International Society of Sports Nutrition

Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis

(2020) Hai P. Nguyen et al.   MOLECULAR CELL

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

The role of hepcidin and iron homeostasis in atherosclerosis

(2020) Florian Wunderer et al.   PHARMACOLOGICAL RESEARCH

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: A review of in vivo and in vitro studies

(2020) Jian Zhang   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis

(2020) Olga Protchenko et al.   HEPATOLOGY

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction

(2020) Isabel Weigand et al.   Cell Death & Disease

Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses

(2020) Zhaohui Jiang et al.   Scientific Reports

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor

(2020) Yuehong Wang et al.   Redox Biology

Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells

(2020) Yuxue Shang et al.   CELLULAR SIGNALLING

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis in Liver Diseases: An Overview

(2020) Martina Maria Capelletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iron Metabolism in Obesity and Metabolic Syndrome

(2020) Álvaro González-Domínguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silencing of peroxisome proliferator‐activated receptor‐alpha alleviates myocardial injury in diabetic cardiomyopathy by downregulating 3‐hydroxy‐3‐methylglutaryl‐coenzyme A synthase 2 expression

(2020) Li Wang et al.   IUBMB LIFE

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Syringaresinol Protects against Type 1 Diabetic Cardiomyopathy by Alleviating Inflammation Responses, Cardiac Fibrosis, and Oxidative Stress

(2020) Guangru Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Tetrahydrobiopterin in energy metabolism and metabolic diseases

(2020) Hyoung Kyu Kim et al.   PHARMACOLOGICAL RESEARCH

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?

(2020) Lihong Mao et al.   Cell Death & Disease

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

(2020) Pallavi Dubey et al.   Nutrients

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

(2020) Hiroe Sato et al.   Scientific Reports

Bilirubin Protects Transplanted Islets by Targeting Ferroptosis

(2020) Qing Yao et al.   Frontiers in Pharmacology

The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis

(2020) Yi Zhou   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

(2020) Hyoung Kyu Kim et al.   Life Science Alliance

Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model

(2020) Wen‐Dai Bao et al.   AGING CELL

p21 can be a barrier to ferroptosis independent of p53

(2020) Divya Venkatesh et al.   Aging-US

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostate Cancer Models

(2020) Jessica Bordini et al.   CLINICAL CANCER RESEARCH

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

(2020) Huimei Zang et al.   DIABETES

Pathophysiology of Type 2 Diabetes Mellitus

(2020) Unai Galicia-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats

(2020) Yuehui Zhang et al.   JOURNAL OF ENDOCRINOLOGY

HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes

(2020) Nian Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel therapeutic intervention of coenzyme Q10 and its combination with pioglitazone on the mRNA expression level of adipocytokines in diabetic rats

(2020) Rajesh A. Maheshwari et al.   LIFE SCIENCES

Isoliquiritigenin Derivatives Inhibit RANKL-Induced Osteoclastogenesis by Regulating p38 and NF-κB Activation in RAW 264.7 Cells

(2020) Seongtae Jeong et al.   MOLECULES

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway

(2020) Wenshuai Ma et al.   Oxidative Medicine and Cellular Longevity

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

(2020) Dan Li et al.   Nutrients

Selenium deficiency is linearly associated with hypoglycemia in healthy adults

(2020) Yue Wang et al.   Redox Biology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

(2020) Yue Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1/Nrf2 signaling‐modulated mitochondrial dysfunction and oxidative stress

(2020) Jing Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

(2020) Bo Yan et al.   MOLECULAR CELL

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

(2020) Hongdong Ma et al.   Oxidative Medicine and Cellular Longevity

Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease

(2020) Yuwei Yang et al.   TOXICOLOGY

Response to iron overload in cultured hepatocytes

(2020) Hsuan-Ju Chen et al.   Scientific Reports

Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

(2020) Xumin Zhou et al.   PHARMACOLOGICAL RESEARCH

Attenuation of Myocardial ischemia reperfusion injury by Geniposide preconditioning in diabetic rats

(2019) Jia wang et al.   Current Research in Translational Medicine

Andrographolide stimulates osteoblastogenesis and bone formation by inhibiting nuclear factor kappa-Β signaling both in vivo and in vitro

(2019) Chang Yongyun et al.   Journal of Orthopaedic Translation

Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction

(2019) Tingting Shu et al.   Endocrine Connections

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1

(2019) Yilei Zhang et al.   CELL CYCLE

SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

(2019) Chenguang Li et al.   Cardiovascular Diabetology

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Obeticholic acid protects against diabetic cardiomyopathy by activation of FXR/Nrf2 signaling in db/db mice

(2019) Hongkui Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice

(2019) Chethan Sampath et al.   FREE RADICAL BIOLOGY AND MEDICINE

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

(2019) Zhi-Dong Ge et al.   International Heart Journal

Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function

(2019) Chi Xiao et al.   Oxidative Medicine and Cellular Longevity

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

(2019) Julia I-Ju Leu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Interferon-γ induces cancer cell ferroptosis

(2019) Laurence Zitvogel et al.   CELL RESEARCH

Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial

(2019) Fernando Bril et al.   DIABETES CARE

PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance

(2019) Yan Wang et al.   ENVIRONMENTAL POLLUTION

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

(2019) Abhinav Kanwal et al.   FASEB JOURNAL

Effects of coenzyme Q10 intervention on diabetic kidney disease

(2019) Xiaofeng Zhang et al.   MEDICINE

Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects

(2019) Ran Li et al.   Oxidative Medicine and Cellular Longevity

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

The Effect of Abnormal Iron Metabolism on Osteoporosis

(2019) Jingmin Che et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Piceatannol alleviates inflammation and oxidative stress via modulation of the Nrf2/HO-1 and NF-κB pathways in diabetic cardiomyopathy

(2019) Hao Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Chronic iron overload intensifies atherosclerosis in apolipoprotein E deficient mice: Role of oxidative stress and endothelial dysfunction

(2019) Vinícius Bermond Marques et al.   LIFE SCIENCES

Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury

(2019) Su Jung Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Iron and Atherosclerosis: The Link Revisited

(2019) Suowen Xu   TRENDS IN MOLECULAR MEDICINE

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Zinc supplementation protects against diabetic endothelial dysfunction via GTP cyclohydrolase 1 restoration

(2019) Peining Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

(2019) Mengyu Yu et al.   CANCER SCIENCE

CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes

(2019) Cheng Wang et al.   DIABETES

Glucose dysregulation in patients with iron overload: is there a relationship with quantitative pancreas and liver iron and fat content measured by MRI?

(2019) Joshua Shur et al.   EUROPEAN RADIOLOGY

Atherosclerosis and Coenzyme Q10

(2019) Juan M. Suárez-Rivero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis

(2019) Yu-Chin Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

(2019) Alexia Belavgeni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study

(2019) Giuseppe Derosa et al.   Drug Design Development and Therapy

Ubiquinol Supplementation Alters Exercise Induced Fatigue by Increasing Lipid Utilization in Mice

(2019) Huan-Chieh Chen et al.   Nutrients

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence

(2019) Jinsen Lu et al.   Scientific Reports

Resveratrol increase myocardial Nrf2 expression in type 2 diabetic rats and alleviate myocardial ischemia/reperfusion injury (MIRI)

(2019) Guiping Xu et al.   Annals of Palliative Medicine

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Saxagliptin protects against hypoxia-induced damage in H9c2 cells

(2019) Lili Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond

(2019) Lutz Schomburg   Hormones-International Journal of Endocrinology and Metabolism

Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats

(2019) Jierong Luo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function

(2019) Yike Sun et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo

(2018) Yue Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling

(2018) Lu Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of Monocolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome

(2018) Alberto Mazza et al.   BIOMEDICINE & PHARMACOTHERAPY

Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats

(2018) Ramoji Kosuru et al.   CARDIOVASCULAR DRUGS AND THERAPY

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

(2018) Gillian Douglas et al.   CARDIOVASCULAR RESEARCH

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Regulated Cell Death Seen through the Lens of Islet Transplantation

(2018) Antonio Bruni et al.   CELL TRANSPLANTATION

Pancreatic islet-autonomous effect of arsenic on insulin secretion through endoplasmic reticulum stress-autophagy pathway

(2018) Wei Wu et al.   FOOD AND CHEMICAL TOXICOLOGY

Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals

(2018) Peiwen Zhang et al.   Journal of Clinical Lipidology

GYY4137 protects against myocardial ischemia/reperfusion injury via activation of the PHLPP-1/Akt/Nrf2 signaling pathway in diabetic mice

(2018) Yun Qiu et al.   JOURNAL OF SURGICAL RESEARCH

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress

(2018) Ehsan Dehdashtian et al.   LIFE SCIENCES

Alterations in System xc− Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2

(2018) Raul Carpi-Santos et al.   MOLECULAR NEUROBIOLOGY

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-κB-Mediated Inflammation

(2018) Ershun Liang et al.   Oxidative Medicine and Cellular Longevity

Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

(2018) Bin Zhang et al.   Oxidative Medicine and Cellular Longevity

Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia

(2018) Fallon K. Lutchmansingh et al.   PLoS One

Protection by dimethyl fumarate against diabetic cardiomyopathy in type 1 diabetic mice likely via activation of nuclear factor erythroid-2 related factor 2

(2018) Xinyue Hu et al.   TOXICOLOGY LETTERS

Ferroptosis-inducing agents compromise in vitro human islet viability and function

(2018) Antonio Bruni et al.   Cell Death & Disease

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart

(2018) Hong Yang et al.   Cell Death & Disease

Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice

(2018) Xiaochen Chen et al.   Scientific Reports

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

(2018) Nana Kobayashi et al.   Scientific Reports

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

(2018) Daniel J Fazakerley et al.   eLife

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotine induces endothelial dysfunction and promotes atherosclerosis via GTPCH1

(2018) Jingyuan Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro

(2018) Zheng Jing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2018) Shi-ying Zhang et al.   International Journal of Endocrinology

Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells

(2018) Christopher M. Carmean et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells

(2018) Qiaoting Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis

(2018) Nasrin Sadeghiyan Galeshkalami et al.   LIFE SCIENCES

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats

(2018) Mustafa S. Atta et al.   Oxidative Medicine and Cellular Longevity

Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses

(2018) Li Li et al.   PHYTOMEDICINE

The progression of HMGB1-induced autophagy in cancer biology

(2018) Tianwei Xu et al.   OncoTargets and Therapy

Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling

(2018) Bin Zhang et al.   Frontiers in Pharmacology

Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress

(2018) Yin Ying et al.   Frontiers in Endocrinology

ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity

(2017) Ilir Mehmeti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice

(2017) Shudong Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

(2017) Pranavi Koppula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH4 improves postprandial endothelial function after a high-fat meal in men and postmenopausal women

(2017) Yashesh Shah et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression

(2017) Phiwayinkosi Dludla et al.   MOLECULES

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

(2017) Hai-han Liao et al.   Oxidative Medicine and Cellular Longevity

SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice

(2017) Sai Ma et al.   Oxidative Medicine and Cellular Longevity

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

(2017) Jialin Duan et al.   Scientific Reports

Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen

(2017) Qian Cheng et al.   Biomed Research International

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy

(2017) Bin Zhang et al.   Scientific Reports

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

(2016) Junlian Gu et al.   DIABETES

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

(2016) Maria Grau-Pérez et al.   DIABETES CARE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice

(2016) Zheng Xu et al.   Scientific Reports

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy

(2016) Hsiang-En Wu et al.   Scientific Reports

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes

(2015) José Manuel Fernández-Real et al.   DIABETES CARE

The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome

(2015) Fariba Raygan et al.   EUROPEAN JOURNAL OF NUTRITION

Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1

(2015) Haobo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased duodenal iron absorption through up-regulation of divalent metal transporter 1 from enhancement of iron regulatory protein 1 activity in patients with nonalcoholic steatohepatitis

(2015) Toshifumi Hoki et al.   HEPATOLOGY

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2)

(2015) Mahmoud M. Elguindy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation

(2015) Xiaoqing Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Association between serum selenium level and type 2 diabetes mellitus: a non-linear dose–response meta-analysis of observational studies

(2015) Xin-liang Wang et al.   Nutrition Journal

Therapeutic Effect of Deferoxamine on Iron Overload-Induced Inhibition of Osteogenesis in a Zebrafish Model

(2014) Bin Chen et al.   CALCIFIED TISSUE INTERNATIONAL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Does reversible cysteine oxidation link the Western diet to cardiac dysfunction?

(2014) Jessica B. Behring et al.   FASEB JOURNAL

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

(2014) Zhiguo Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells

(2014) S Lortz et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines

(2014) Qiang Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase

(2013) Walter A. Baseler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol

(2013) Eva-Maria Küch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy

(2013) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system xc- cystine/glutamate exchanger

(2013) J.L. Newell et al.   NEUROCHEMISTRY INTERNATIONAL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

(2012) J. Xu et al.   DIABETES

Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes

(2012) K. Huynh et al.   DIABETOLOGIA

Iron homeostasis in osteoporosis and its clinical implications

(2012) G. F. Li et al.   OSTEOPOROSIS INTERNATIONAL

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Serum Levels of Hepcidin in Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease

(2011) Ebubekir Senates et al.   Metabolic Syndrome and Related Disorders

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian iron transport

(2009) Gregory Jon Anderson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat

(2008) Alireza Shirpoor et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS