Ferroptosis in Liver Diseases: An Overview

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis—A Novel Form of Non-Apoptotic Cell Death?

(2020) Ricardo U. Macías-Rodríguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Ferroptosis in Cancer Cell Biology

(2020) Christina M. Bebber et al.   Cancers

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Ferritins in Kidney Disease

(2020) Kayla McCullough et al.   SEMINARS IN NEPHROLOGY

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Processes exacerbating apoptosis in non-alcoholic steatohepatitis

(2019) Marta B. Afonso et al.   CLINICAL SCIENCE

Mitochondria regulation in ferroptosis

(2019) Hai Wang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance

(2019) Nan Liu et al.   BRITISH JOURNAL OF CANCER

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of ferroptosis in hepatocellular carcinoma

(2018) Jianhua Nie et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes

(2018) Tasuku Hirayama et al.   Metallomics

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production

(2017) Jaeyong Lee et al.   EXPERIMENTAL CELL RESEARCH

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

(2017) Weijun Ou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drug-induced liver injury: recent advances in diagnosis and risk assessment

(2017) Gerd A Kullak-Ublick et al.   GUT

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease

(2017) Raed Daher et al.   PRESSE MEDICALE

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

(2017) Tiago L. Duarte et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters

(2015) Simon Newstead   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Liver Ischemia/Reperfusion Injury: an Overview

(2014) Rezà F. Saidi et al.   JOURNAL OF INVESTIGATIVE SURGERY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE