Article
Biochemistry & Molecular Biology
Hsiu-Chu Chou, Chung-Ming Chen
Summary: The study investigates the effects of hyperoxia on lung ferroptosis and development in neonatal mice. The findings suggest that ferroptosis may contribute to the pathogenesis of hyperoxia-induced lung injury and that ferroptosis inhibitors might attenuate this injury.
Article
Biochemistry & Molecular Biology
Che-Yuan Hu, Hung-Tsung Wu, Yan-Shen Shan, Chung-Teng Wang, Gia-Shing Shieh, Chao-Liang Wu, Horng-Yih Ou
Summary: Evodiamine (EVO) inhibits cell proliferation and induces ferroptosis in bladder cancer cells, as shown by decreased lipid peroxide levels and GPX4 expression. EVO treatment also suppresses tumor growth and epithelial-mesenchymal transition (EMT) in a bladder tumor xenograft model. These findings suggest that EVO may be a potential therapeutic agent for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao
Summary: This article discusses the interplay between ferroptosis and tumor-related signaling pathways, and comprehensively summarizes the small-molecule compounds that may regulate cancer cell death by inducing ferroptosis, which will shed new light on the development of ferroptosis-related anticancer drugs in the future.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Yu'e Liu, Shiping Lu, Lei-lei Wu, Liang Yang, Lixue Yang, Jinghan Wang
Summary: Ferroptosis is a regulated form of cell death induced by iron-dependent lipid peroxidation. It is modulated by various cellular pathways and mitochondria play a unique role in ferroptosis. Targeting ferroptosis in cancer cells shows promising potential for treating drug-resistant cancers.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki, Banibrata Mukhopadhyay, Wulf Tonnus, Sze Men Choi, Ria Roelandt, Catalina Dumitrascu, Ludwig Lamberts, Geert Dams, Wannes Weyts, Jelle Huysentruyt, Behrouz Hassannia, Irina Ingold, Suhas Lele, Evelyne Meyer, Maya Berg, Ruth Seurinck, Yvan Saeys, An Vermeulen, Alexander L. N. van Nuijs, Marcus Conrad, Andreas Linkermann, Mohan Rajapurkar, Peter Vandenabeele, Eric Hoste, Koen Augustyns, Tom Vanden Berghe
Summary: The development of multiorgan dysfunction syndrome (MODS) is the most common cause of death in the intensive care unit (ICU). Catalytic iron is associated with ICU mortality and may induce excessive lipid peroxidation, leading to cellular toxicity and multiorgan dysfunction. Blocking lipid peroxidation with a ferrostatin-analogue can protect mice from injury and death in experimental non-septic MODS.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Cancer cells reprogram their metabolism to a mesenchymal state, making them resistant to therapy but susceptible to ferroptosis induction. Ferroptosis is a regulated cell death process based on iron-dependent lipid peroxidation. Glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis and its synthesis and expression can be controlled through various levels of regulation. Targeting GPX4 may be a promising strategy for inducing ferroptosis and killing therapy-resistant cancer cells.
Article
Multidisciplinary Sciences
Rong Du, Xi Cheng, Jingjing Ji, Yang Lu, Yuanyuan Xie, Weina Wang, Yanhua Xu, Yuquan Zhang
Summary: This study aimed to investigate the association between ferroptosis and premature ovarian insufficiency (POI) caused by cisplatin (CDDP) and the potential therapeutic effect of vitamin E (VE). The results showed that CDDP induced ovarian tissue fibrosis and follicle development disorders along with impaired ovarian function, while VE could reverse these reproductive toxicities. Furthermore, molecular experiments revealed that ferroptosis-related molecules ACSl4, ALOX15, SLC7A11, and GPX4 were differentially expressed, suggesting their involvement in the mechanism of POI.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Guimei Zhang, Yaru Zhang, Yanxin Shen, Yongchun Wang, Meng Zhao, Li Sun
Summary: Alzheimer's disease is the most common cause of dementia, but the exact mechanism is still unclear. Recent research has shown that iron metabolism, lipid peroxidation, and oxidative stress play vital roles in the pathogenesis of AD, and the iron-dependent cell death known as ferroptosis may be involved in neurological disorders, including AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Editorial Material
Cell Biology
Eikan Mishima, Marcus Conrad
Summary: A recent study reveals that the metabolic enzyme creatinine kinase B (CKB) phosphorylates the protein GPX4, which could potentially affect the susceptibility of cancer cells to ferroptosis.
NATURE CELL BIOLOGY
(2023)
Article
Fisheries
Paulina Estrada-Cardenas, Alma B. Peregrino-Uriarte, Gloria Yepiz-Plascencia
Summary: This study investigated the changes of HIF-1 alpha and ferroptosis process components in GPx4 knock-down shrimp exposed to hypoxia and reoxygenation. The results showed that GPx4 knock-down increased ACSL4 expression, MDA content, and CAT activity, further inducing ferroptosis process in the hepatopancreas.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiaoqin Zeng, Jingda Li, Fuyuan Yang, Rui Xia
Summary: Ferroptosis is a novel form of programmed cell death characterized by iron-mediated lipid peroxidation induced by reactive oxygen species, distinct from apoptosis, necroptosis, and other forms of cell death. There is limited research on the effects of anesthetics on ferroptosis, making it important to understand the mechanisms for potential clinical applications and disease treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shiyao Sui, Shouping Xu, Da Pang
Summary: Breast cancer is a significant threat to women's health, and ferroptosis may offer a new direction for breast cancer treatment. However, the complete appearance of ferroptosis in breast cancer and its potential combination with traditional anti-breast cancer drugs remain uncertain. This review explores the roles of various factors associated with ferroptosis in breast cancer, provides evidence of ferroptosis induction by traditional drugs and elimination of breast cancer cells by ferroptosis inducers, and discusses the prospects and potential obstacles of using ferroptosis inducers in breast cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Mingliang Chen, Zhihao Shi, Yuqiu Sun, Haoran Ning, Xinyu Gu, Lei Zhang
Summary: Ferroptosis is a novel form of iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Glutathione peroxidase 4 (GPX4) plays a critical role in protecting cells from ferroptosis. Research on ferroptosis in cancer therapy, especially in acquired drug resistance, has led to the development of therapeutic drugs targeting GPX4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kenji M. Fujihara, Bonnie Z. Zhang, Nicholas J. Clemons
Summary: Ferroptosis, a form of cell death characterized by lipid peroxidation and iron accumulation, has shown potential as an alternative therapeutic strategy for destroying tumors. Despite extensive research on its molecular mechanisms, translating this knowledge into clinical compounds remains a challenge. This perspective elaborates on leveraging ferroptosis in the clinic, discussing therapeutic windows, tumor sensitivity, conventional therapeutics, and strategies to enhance ferroptosis.
Article
Biochemistry & Molecular Biology
Rui Wang, Qi Su, Hongzhuan Yin, Di Wu, Chi Lv, Zhaopeng Yan
Summary: This study demonstrates that SRSF9 plays a significant role in the sensitivity of colorectal cancer cells to erastin-induced ferroptosis, by reducing lipid peroxide damage and regulating GPX4 levels. These findings suggest that targeting SRSF9 may offer a novel approach to enhance the sensitivity of CRC to erastin treatment.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)