Article
Chemistry, Multidisciplinary
Hao Xin, Fang Wang, Rengan Luo, Jianping Lei
Summary: This study developed a parallel lipid peroxide accumulation strategy using metal-organic frameworks and glutathione-responsive cleavage to enhance ferrotherapy efficacy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Materials Science, Biomaterials
Yuyu Zhong, Zhaoxi Peng, Yanqiong Peng, Bo Li, Ying Pan, Qin Ouyang, Hiroshi Sakiyama, Mohd. Muddassir, Jianqiang Liu
Summary: Ferroptosis-induced reactive oxygen species (ROS) generation is a promising strategy for cancer treatment. Facile bimetallic nanoparticles, specifically 7% Fe-doped ZIF-8 (7FZ), were synthesized and tested for encapsulating the classic drug doxorubicin (DOX) for breast cancer therapy. DOX@7FZ showed high drug loading efficiency of 58.01 ± 0.02% and effectively enhanced ROS levels, leading to significant decrease in cell viability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Lingfeng Liu, Huan Jin, Mengyuan Dong, Jingwen Tian, Hongsheng Li, Quentin Liu, Yibing Chen, Zhengzhi Zou
Summary: This study identified a potential biomarker, FRGsig, for predicting the prognosis and response to immunotherapy in different subtypes of renal cell carcinoma. High FRGsig score was associated with poor prognosis and higher levels of anti-tumor immunity cells infiltration. FRGsig could be used in patient selection for angiogenic blocking drugs or immune checkpoint inhibitors.
Review
Oncology
Zhengzhen Xia, Yi Quan
Summary: Ferroptosis is a lipid peroxidation-induced, iron-dependent programmed cell death that is closely associated with tumorigenesis, development, treatment, and tumor immune regulation. This study investigates the connection between ferroptosis and immune regulation, providing a theoretical basis for targeting ferroptosis and tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuanyuan Ma, Zheng Su, Liming Zhou, Liangcan He, Zhenyu Hou, Jianhua Zou, Yu Cai, Di Chang, Jinbing Xie, Chen Zhu, Wenpei Fan, Xiaoyuan Chen, Shenghong Ju
Summary: This study achieved targeted delivery of cisplatin using biocompatible and biodegradable hollow mesoporous organosilica (HMOS) nanoparticles by blocking the pores with a bimetallic Zn2+/Cu2+ co-doped metal-organic framework (MOF). The MOF decomposes in the acidic tumor microenvironment to release cisplatin for chemotherapy, while the released Cu2+ depletes intracellular glutathione (GSH) and catalyzes the decomposition of intratumoral H2O2 into highly toxic •OH for chemodynamic therapy. The reduced GSH also protects the •OH from scavenging, enhancing the chemodynamic therapy effect.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yue Cheng, Cong Wen, Yi-Qing Sun, Hua Yu, Xue-Bo Yin
Summary: This study proposes a trimodality therapy using a mixed-metal MOF composite for synergistic photothermal therapy, photodynamic therapy, and chemodynamic therapy. The composite with hollow structures efficiently integrates multiple functions to enhance treatment efficacy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Cheng Tan, Jianqiang Wu, Zhi Wen
Summary: The study introduced Doxorubicin-loaded MnO2@zeolitic imidazolate framework-8 (DOX/MnO2@ZIF-8) nanoparticles for lung cancer treatment. Results showed that the nanoparticles had excellent photothermal conversion effect both in vitro and in vivo, and could effectively release drugs to inhibit the cell viability of lung cancer cells.
Review
Materials Science, Biomaterials
Hajra Zafar, Faisal Raza, Siyu Ma, Yawen Wei, Jun Zhang, Qi Shen
Summary: Ferroptosis, a form of non-apoptotic cell death, shows potential in eliminating aggressive malignancies resistant to traditional therapies. The combination of nanomedicine and ferroptosis has shown efficacy in treating various types of cancer.
BIOMATERIALS SCIENCE
(2021)
Review
Cell Biology
Chuandong Gong, Qiankun Ji, Miaojing Wu, Zewei Tu, Kunjian Lei, Min Luo, Junzhe Liu, Li Lin, Kuangxun Li, Jingying Li, Kai Huang, Xingen Zhu
Summary: This review outlines the immune-related effects of ferroptosis pathways in tumor progression and treatment, and discusses potential methods for improving anti-tumor immunity and enhancing the efficacy of current cancer treatments by targeting ferroptosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Oncology
Yonghao Sun, Zuoxing Xue, Tao Huang, Xiangyu Che, Guangzhen Wu
Summary: Ferroptosis is a type of regulated cell death mediated by lipid peroxidation and iron dependence, which is closely associated with various diseases, including cancer. Changes in lipid metabolism, such as lipid peroxidation and ferroptosis, play critical roles in cancer therapy. This review provides an overview of the characteristics of ferroptosis and analyzes the connections between several metabolic mechanisms and ferroptosis. The effects of lipid peroxides, signaling pathways, and molecules involved in lipid metabolism on ferroptosis are extensively discussed. Furthermore, the review highlights ferroptosis-based treatments and provides examples of their combination with other therapies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yi Wang, HongJing Li, QianXiong He, Rong Zou, JinRui Cai, Lin Zhang
Summary: Ferroptosis, a unique mode of cell death, has been found to be closely correlated with neurodegenerative diseases. Pharmacological modulation of ferroptosis shows promise in therapeutic interventions for these diseases.
Article
Oncology
Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Qin Wang, Chunyan Zhu, Chao Fang, Junjie Liu, Kun Zhang, Yan Liu
Summary: In this study, exosomes derived from M1 macrophages were engineered to deliver RSL3 and induce ferroptosis in tumor cells, activating immune responses and mitigating the immunosuppressive tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, General & Internal
Liuliu Zi, Wangbin Ma, Lilong Zhang, Boyang Qiao, Zhendong Qiu, Junhui Xu, Jiacheng Zhang, Yahong Ye, Yueyuan Yang, Keshuai Dong, Chen Chen, Weixing Wang, Qingyan Zhao
Summary: This study reveals that uridine levels are altered in the tumor microenvironment of hepatocellular carcinoma (HCC) patients and suggests uridine as a potential target for HCC therapy. Gene expression analysis shows increased levels of CAD and DHODH in HCC tissues. LC-MS/MS assays further confirm differences in uridine content between non-tumor and tumor tissues. In vitro and in vivo experiments demonstrate that uridine inhibits the proliferation, invasion, and migration of HCC cells through activation of the ferroptosis pathway. These findings provide important insights into the role of uridine in HCC and its potential as a therapeutic target.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiaolin Tan, Donghui Liao, Congying Rao, Luyi Zhou, Zhichen Tan, Ying Pan, Amita Singh, Abhinav Kumar, Jianqiang Liu, Baohong Li
Summary: Chemodynamic therapy (CDT) is a new therapeutic technique for treating tumors by disrupting tumor cell proliferation and development through oxidative stress. Metal-organic frameworks (MOFs) can release metal ions in the tumor microenvironment, catalyzing the production of hydroxyl radicals to destroy tumor cells. Therefore, functionalized MOFs have great potential in enhancing the efficacy of CDT in biomedical tumor treatment.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yu Liang, Li Zhang, Chao Peng, Shiyu Zhang, Siwen Chen, Xin Qian, Wanxian Luo, Qing Dan, Yongyan Ren, Yingjia Li, Bingxia Zhao
Summary: Novel tumor microenvironment-activated metal-organic frameworks involving Fe & Cu ions were developed for targeted ferroptosis therapy, releasing Fe ions and inhibiting GPX4 to induce cell death. These frameworks can generate more ROS under specific TME conditions, showing promising anti-tumor efficacy.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Oncology
Peng Li, Xinhai Zhu, Guangchao Cao, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin, Ligong Lu, Yunfei Gao
Summary: This study demonstrates that serum vitamin D level is negatively correlated with the expression of PD-1, TIGIT, and Tim-3, while positively correlated with the expression of CD28 on CD8(+) and V gamma 9V delta 2(+) T cells in patients with NSCLC. The active form of vitamin D, 1 alpha,25(OH)(2)D-3, promotes the nuclear translocation of VDR and inhibits the expression of ICRs by binding to their promoter regions. In addition, VDR-mediated Ca2+ influx enhances Th1 cytokine production and increases antitumor immunity in T cells. Overall, this research highlights the pleiotropic effects of 1 alpha,25(OH)(2)D-3 in rescuing exhausted cytotoxic T cells and promoting antitumor immunity in patients with tumor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Linjun Liang, Hongfa Xu, Qichao Dong, Lige Qiu, Ligong Lu, Qing Yang, Wei Zhao, Yong Li
Summary: This study found that the expression of WTAP in hepatocellular carcinoma is associated with clinical characteristics of patients and can serve as an independent prognostic factor. Through genetic profiling and pathway analysis, it was also discovered that WTAP may be involved in regulating cytokines, cell cycle, and immune cell infiltration. Additionally, WTAP knockdown experiments demonstrated its potential as a therapeutic target by inhibiting HCC proliferation and aggressiveness.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Zhiren Zhang, Qiaren He, Wei Zhao, Yong Li, Jiaming Yang, Zhenxiang Hu, Xi Chen, Hua Peng, Yang-Xin Fu, Long Chen, Ligong Lu
Summary: Two pilot studies were conducted to evaluate the safety and immunogenicity of V-01 and V-01D-351 as booster shots for COVID-19 vaccines. The results showed that the heterologous boosters induced stronger immune responses, particularly V-01D-351, which had high neutralizing antibody titers against various variants. These studies provide evidence for the use of heterologous boosters and variant-specific vaccine boosters to build herd immunity against the ongoing pandemic.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Peng Li, Wenhui Yuan, Ruan Wu, Chuqian Zeng, Ke Li, Ligong Lu
Summary: Endocrine therapy is effective for ER and PR-positive breast cancer, but resistance is a major cause of mortality. Immune checkpoint receptor blockade is another treatment approach, but less effective for non-TNBC. Androgen receptor has been found to suppress tumors in ER-positive breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiujuan Liu, Jun Mao, Ning Sun, Xiangrong Yu, Lei Chai, Ye Tian, Jianming Wang, Jianchao Liang, Haiquan Tao, Lihua Yuan, Jiaming Lu, Yang Wang, Bing Zhang, Kaihua Wu, Yiding Wang, Mengjiao Chen, Zhishun Wang, Ligong Lu
Summary: This study developed a new method using deep learning to automatically detect intracranial aneurysms from CTA images. The performance of the method was evaluated, showing reliable segmentation and detection of intracranial aneurysms, with a sensitivity of 100% for large and medium-sized aneurysms.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ma Luo, Sheng Peng, Guang Yang, Letao Lin, Ligong Lu, Jiawen Chen, Fujun Zhang, Fei Gao
Summary: This study compared the effectiveness and outcomes of percutaneous ablation guided by ultrasonography (US) and computed tomography (CT) in the treatment of colorectal liver oligometastases (CLOM). The results showed that US-guided ablation had shorter procedure time and lower cost compared to CT-guided ablation. For patients over 60 years old or with perivascular liver lesions, US-guided ablation had better local tumor progression (LTP)-free survival.
Article
Engineering, Biomedical
Yanhong Su, Zhao Zhang, Leo Tsz On Lee, Ling Peng, Ligong Lu, Xu He, Xuanjun Zhang
Summary: This study reports a nanoplatform for co-delivery of the anticancer drug sorafenib and the ferroptosis inducer hemin, enabling synergistic ferroptosis-apoptosis therapy of advanced hepatocellular carcinoma. The study demonstrates the efficacy of ferroptosis-apoptosis combination therapy and the promise of TME-responsive vesicles for drug delivery in treating advanced HCC.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Liewei Wen, Hongyi Liu, Cong Hu, Zixuan Wei, Ya Meng, Cuixia Lu, Yanhong Su, Ligong Lu, Hui Liang, Qingbo Xu, Meixiao Zhan
Summary: Imaging-guided percutaneous microwave thermotherapy is an important alternative nonsurgical therapeutic strategy for hepatocellular carcinoma (HCC), providing excellent local tumor control and survival benefit. However, there is an urgent need for a high-resolution, real-time, noninvasive imaging technique for intraoperative guidance and control of postoperative tumor recurrence.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Jiawen He, Ruixiang Song, Fengfeng Xiao, Meng Wang, Liewei Wen
Summary: Photothermal therapy (PTT) is a promising anticancer treatment that involves inducing thermal ablation and enhancing antitumor immune responses. Combining photothermal and immunotherapy is believed to be a more effective treatment approach as it can modulate the immune microenvironment and amplify the post-ablation immune response.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Meixiao Zhan, Yufeng Ding, Shanzhou Huang, Yuhang Liu, Jing Xiao, Hua Yu, Ligong Lu, Xiongjun Wang
Summary: By phosphorylating and stabilizing DHODH, sensitivity of liver cancer cells to Oxaliplatin is enhanced.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Zixuan Wei, Xiaoya Yu, Mao Huang, Liewei Wen, Cuixia Lu
Summary: Minimally invasive ablation is widely used for the treatment of various solid tumors. It not only removes the primary tumor but also improves the anti-tumor immune response by inducing immunogenic tumor cell death and modulating the tumor immune microenvironment, which can be beneficial in preventing recurrent metastasis of residual tumor.
Article
Immunology
Ke Li, Eying Lu, Qian Wang, Ruirong Xu, Wenhui Yuan, Ruan Wu, Ligong Lu, Peng Li
Summary: The frequency of circulating V delta 2(+) T cells and serum levels of vitamin 25(OH)D-3 were significantly decreased in HBV patients. Serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on gamma delta T cells. Moreover, 1 alpha,25 (OH)(2)D-3 alleviated the exhaustion phenotype of V delta 2 T cells in HBV-infected patients and promoted IFN-γ expression in human cytotoxic V delta 2 T cells in vitro.
Article
Nanoscience & Nanotechnology
Jiawen He, Xumei Ouyang, Fengfeng Xiao, Ning Liu, Liewei Wen
Summary: Phototherapy has great application prospects in treating superficial tumors, but there are still challenges. In this study, a nanocomposite was developed that could accurately delineate the tumor region, destroy tumor cells, and stimulate the immune response, which may provide a promising nanoplatform for optical theranostics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yunong Ma, Xi Zhao, Peilin Tian, Kexin Xu, Jiayang Luo, Honghui Li, Mingqing Yuan, Xu Liu, Yanping Zhong, Pingzhen Wei, Jiaxing Song, Liewei Wen, Cuixia Lu
Summary: A glutathione-activatable nano-photosensitizer is developed to enhance the effectiveness of photodynamic therapy (PDT) by driving ferroptosis in cancer cells through continuous lipid peroxidation reactions. The residual tumor cells undergoing ferroptosis also maintain high immunogenicity, promoting the anti-tumor immune response.
Letter
Biochemistry & Molecular Biology
Gen Li, Zhongcheng Zhou, Peng Du, Meixiao Zhan, Ning Li, Xinxin Xiong, Shengjun Tang, Miao Man, Daniel T. Baptista-Hon, Ligong Lu
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
