Redox homeostasis maintained by GPX4 facilitates STING activation

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

(2018) Ying Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity

(2018) Pengyan Xia et al.   NATURE IMMUNOLOGY

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Selenium-Encoded Isotopic Signature Targeted Profiling

(2018) Jinjun Gao et al.   ACS Central Science

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

(2018) Anne Louise Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

(2018) Sonal Srikanth et al.   NATURE IMMUNOLOGY

USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses

(2017) Zhongxia Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

(2017) Vijay K. Gonugunta et al.   Cell Reports

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses

(2016) Wanwan Huai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Redox homeostasis: The Golden Mean of healthy living

(2016) Fulvio Ursini et al.   Redox Biology

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

Viruses transfer the antiviral second messenger cGAMP between cells

(2015) A. Bridgeman et al.   SCIENCE

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal

(2014) Jolanta Czerwińska et al.   NUCLEIC ACIDS RESEARCH

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

Mechanism of protein decarbonylation

(2013) Chi-Ming Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Accumulation of oxidized proteins in Herpesvirus infected cells

(2010) Shomita S. Mathew et al.   FREE RADICAL BIOLOGY AND MEDICINE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE