Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport

Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7

(2022) Luke S. Ferro et al.   SCIENCE

Structural basis for cytoplasmic dynein-1 regulation by Lis1

(2022) John P Gillies et al.   eLife

A kinesin-1 variant reveals motor-induced microtubule damage in cells

(2022) Breane G. Budaitis et al.   CURRENT BIOLOGY

An ALS ‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity

(2022) Juri Nakano et al.   GENES TO CELLS

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function

(2022) Desiree M. Baron et al.   Cell Reports

Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity

(2022) Kyoko Chiba et al.   Cell Reports

Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport

(2022) Sharon R. Garrott et al.   Frontiers in Cell and Developmental Biology

The type V myosin-containing complex HUM is a RAB11 effector powering movement of secretory vesicles

(2022) Mario Pinar et al.   iScience

ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function

(2022) Devesh C Pant et al.   EMBO REPORTS

JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

(2022) Ricardo Celestino et al.   JOURNAL OF CELL BIOLOGY

Multiple roles for the cytoskeleton in ALS

(2022) Xinbei Liu et al.   EXPERIMENTAL NEUROLOGY

Tau differentially regulates the transport of early endosomes and lysosomes

(2022) Linda Balabanian et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of dynein–dynactin on microtubules shows tandem adaptor binding

(2022) Sami Chaaban et al.   NATURE

Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

(2022) Allison M Gicking et al.   eLife

Molecular architecture of the autoinhibited kinesin-1 lambda particle

(2022) Johannes F. Weijman et al.   Science Advances

NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals

(2022) Dane Kawano et al.   iScience

Metaxins are core components of mitochondrial transport adaptor complexes

(2021) Yinsuo Zhao et al.   Nature Communications

The spindle pole-body localization of activated cytoplasmic dynein is cell cycle-dependent in Aspergillus nidulans

(2021) Baronger Dowell Bieger et al.   FUNGAL GENETICS AND BIOLOGY

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes

(2021) C. Alexander Boecker et al.   CURRENT BIOLOGY

Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

(2021) Joseph C. Roney et al.   DEVELOPMENTAL CELL

Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

(2021) Clinton K Lau et al.   EMBO JOURNAL

Motor proteins at the mitochondria–cytoskeleton interface

(2021) Antonina J. Kruppa et al.   JOURNAL OF CELL SCIENCE

The fungal RABOME: RAB GTPases acting in the endocytic and exocytic pathways of Aspergillus nidulans (with excursions to other filamentous fungi)

(2021) Mario Pinar et al.   MOLECULAR MICROBIOLOGY

A CRMP4‐dependent retrograde axon‐to‐soma death signal in amyotrophic lateral sclerosis

(2021) Roy Maimon et al.   EMBO JOURNAL

RUSC2 and WDR47 oppositely regulate kinesin-1–dependent distribution of ATG9A to the cell periphery

(2021) Carlos M. Guardia et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

(2021) Adam R. Fenton et al.   Nature Communications

A novel variant in DYNC1H1 could contribute to human amyotrophic lateral sclerosis-frontotemporal dementia spectrum.

(2021) Alexios-Fotios Mentis et al.   Cold Spring Harbor Molecular Case Studies

Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes

(2021) Jenna R Christensen et al.   eLife

A Combinatorial MAP Code Dictates Polarized Microtubule Transport

(2020) Brigette Y. Monroy et al.   DEVELOPMENTAL CELL

The splicing-factor Prp40 affects dynein–dynactin function in Aspergillus nidulans

(2020) Rongde Qiu et al.   MOLECULAR BIOLOGY OF THE CELL

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

(2020) Matthew G. Marzo et al.   NATURE CELL BIOLOGY

New insights into the mechanism of dynein motor regulation by lissencephaly-1

(2020) Steven M Markus et al.   eLife

Cargo-Mediated Activation of Cytoplasmic Dynein in vivo

(2020) Xin Xiang et al.   Frontiers in Cell and Developmental Biology

ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1

(2020) Tal Keren-Kaplan et al.   CURRENT BIOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C

(2019) Alison E. Twelvetrees et al.   JOURNAL OF CELL SCIENCE

Hot-spot KIF5A mutations cause familial ALS

(2018) David Brenner et al.   BRAIN

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

(2018) Michael T. Kelliher et al.   JOURNAL OF CELL BIOLOGY

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

(2018) Jia Yu et al.   Molecular Neurodegeneration

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

Axonal autophagy: Mini-review for autophagy in the CNS

(2018) Andrea K.H. Stavoe et al.   NEUROSCIENCE LETTERS

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation

(2018) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly

(2018) Jun Zhang et al.   Scientific Reports

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

(2018) Mara A. Olenick et al.   JOURNAL OF CELL BIOLOGY

Transport of fungal RAB11 secretory vesicles involves myosin-5, dynein/dynactin/p25, and kinesin-1 and is independent of kinesin-3

(2017) Miguel A. Peñalva et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule-organizing centers of Aspergillus nidulans are anchored at septa by a disordered protein

(2017) Ying Zhang et al.   MOLECULAR MICROBIOLOGY

Nuclear movement in fungi

(2017) Xin Xiang   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport

(2017) John Salogiannis et al.   TRENDS IN CELL BIOLOGY

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1

(2016) Alison E. Twelvetrees et al.   NEURON

Role of kinesin-1–based microtubule sliding inDrosophilanervous system development

(2016) Michael Winding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule–microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming inDrosophilaoocytes

(2016) Wen Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

(2016) Xiaoli Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases

(2015) Nobutaka Hirokawa et al.   EXPERIMENTAL CELL RESEARCH

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1

(2015) Noga Gershoni-Emek et al.   MOLECULAR & CELLULAR PROTEOMICS

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

(2014) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

(2014) Ewa Bielska et al.   JOURNAL OF CELL BIOLOGY

Maturation of late Golgi cisternae into RabERAB11 exocytic post-Golgi carriers visualized in vivo

(2014) Areti Pantazopoulou et al.   MOLECULAR BIOLOGY OF THE CELL

FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus

(2014) Xuanli Yao et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule plus end-tracking proteins play critical roles in directional growth of hyphae by regulating the dynamics of cytoplasmic microtubules inAspergillus nidulans

(2014) Cui J. Tracy Zeng et al.   MOLECULAR MICROBIOLOGY

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

Reconstitution of dynein transport to the microtubule plus end by kinesin

(2014) Anthony J Roberts et al.   eLife

The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline

(2013) L. S. Williams et al.   DEVELOPMENT

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

(2013) Kensuke Ikenaka et al.   PLoS One

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

Dynactin's pointed-end complex is a cargo-targeting module

(2012) Ting-Yu Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

The p150Glued CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini

(2012) Thomas E. Lloyd et al.   NEURON

Dynactin Is Required for Transport Initiation from the Distal Axon

(2012) Armen J. Moughamian et al.   NEURON

The Functions of Myosin II and Myosin V Homologs in Tip Growth and Septation in Aspergillus nidulans

(2012) Naimeh Taheri-Talesh et al.   PLoS One

Casein kinase 2 reverses tail-independent inactivation of kinesin-1

(2012) Jing Xu et al.   Nature Communications

Regulated Offloading of Cytoplasmic Dynein from Microtubule Plus Ends to the Cortex

(2011) Steven M. Markus et al.   DEVELOPMENTAL CELL

Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase

(2011) Martin Schuster et al.   EMBO JOURNAL

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction

(2011) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein

(2011) M. Arimoto et al.   JOURNAL OF NEUROSCIENCE

Aspergillus Myosin-V Supports Polarized Growth in the Absence of Microtubule-Based Transport

(2011) Jun Zhang et al.   PLoS One

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

(2011) H. Y. K. Kaan et al.   SCIENCE

In Vivo Roles of the Basic Domain of Dynactin p150 in Microtubule Plus-End Tracking and Dynein Function

(2011) Xuanli Yao et al.   TRAFFIC

The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation

(2010) J. Zhang et al.   JOURNAL OF CELL SCIENCE

The Kinesin-1 Tail Conformationally Restricts the Nucleotide Pocket

(2009) Yao Liang Wong et al.   BIOPHYSICAL JOURNAL

Walking the walk: how kinesin and dynein coordinate their steps

(2009) Arne Gennerich et al.   CURRENT OPINION IN CELL BIOLOGY

mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1

(2009) Masami Yamada et al.   EMBO JOURNAL

Opposite-polarity motors activate one another to trigger cargo transport in live cells

(2009) Shabeen Ally et al.   JOURNAL OF CELL BIOLOGY

In vivo analysis of the functions of  -tubulin-complex proteins

(2009) Y. Xiong et al.   JOURNAL OF CELL SCIENCE

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Retrograde axonal transport and motor neuron disease

(2008) Anna-Lena Strm et al.   JOURNAL OF NEUROCHEMISTRY

The Aspergillus nidulans Kinesin-3 UncA Motor Moves Vesicles along a Subpopulation of Microtubules

(2008) Nadine Zekert et al.   MOLECULAR BIOLOGY OF THE CELL

The kinesin-1 motor protein is regulated by a direct interaction of its head and tail

(2008) Kristen A. Dietrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Distance Movement of Aspergillus nidulans Early Endosomes on Microtubule Tracks

(2008) Juan F. Abenza et al.   TRAFFIC

Genetic evidence for a microtubule-destabilizing 
effect of conventional kinesin and analysis of its consequences for the control of nuclear distribution 
in Aspergillus nidulans

(2003) Natalia Requena et al.   MOLECULAR MICROBIOLOGY