LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

Incorporating Motility in the Motor: Role of the Hook Protein Family in Regulating Dynein Motility

(2019) Devashish Dwivedi et al.   BIOCHEMISTRY

Developmental regulators FlbE/D orchestrate the polarity site-to-nucleus dynamics of the fungal bZIP transcription factor FlbB

(2019) Ainara Otamendi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

(2018) Anthony J. Roberts   BIOCHEMICAL SOCIETY TRANSACTIONS

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation

(2018) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly

(2018) Jun Zhang et al.   Scientific Reports

Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1

(2018) Safia Omer et al.   eLife

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

(2018) Mara A. Olenick et al.   JOURNAL OF CELL BIOLOGY

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo

(2017) Patrícia A. Simões et al.   JOURNAL OF CELL SCIENCE

Transport of fungal RAB11 secretory vesicles involves myosin-5, dynein/dynactin/p25, and kinesin-1 and is independent of kinesin-3

(2017) Miguel A. Peñalva et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule-organizing centers of Aspergillus nidulans are anchored at septa by a disordered protein

(2017) Ying Zhang et al.   MOLECULAR MICROBIOLOGY

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport

(2017) Roderick P. Tas et al.   NEURON

DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein–dynactin–cargo adaptor complexes

(2017) Ha Thi Hoang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear migration in mammalian brain development

(2017) Chiara Bertipaglia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nuclear movement in fungi

(2017) Xin Xiang   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay between Phosphorylation Site and Disordered Spliced Linkers

(2017) Jing Jie et al.   STRUCTURE

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA

(2016) John Salogiannis et al.   JOURNAL OF CELL BIOLOGY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1

(2016) Alison E. Twelvetrees et al.   NEURON

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

(2016) Marijn Kuijpers et al.   NEURON

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

(2016) Xiaoli Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

(2016) Babu J. N. Reddy et al.   Nature Communications

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Kinesin-3 in the basidiomycete Ustilago maydis transports organelles along the entire microtubule array

(2015) Gero Steinberg   FUNGAL GENETICS AND BIOLOGY

Two microtubule-plus-end binding proteins LIS1-1 and LIS1-2, homologues of human LIS1 in Neurospora crassa

(2015) Olga A. Callejas-Negrete et al.   FUNGAL GENETICS AND BIOLOGY

Peroxisomes, lipid droplets, and endoplasmic reticulum “hitchhike” on motile early endosomes

(2015) Sofia C. Guimaraes et al.   JOURNAL OF CELL BIOLOGY

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

(2015) Eva Klinman et al.   Cell Reports

Cytoplasmic Dynein Is Required for the Spatial Organization of Protein Aggregates in Filamentous Fungi

(2015) Martin J. Egan et al.   Cell Reports

A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

(2015) Thomas Pohlmann et al.   eLife

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders

(2015) Dick Jaarsma et al.   Frontiers in Neuroscience

Allosteric Communication in the Dynein Motor Domain

(2014) Gira Bhabha et al.   CELL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Early endosome motility spatially organizes polysome distribution

(2014) Yujiro Higuchi et al.   JOURNAL OF CELL BIOLOGY

HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

(2014) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

(2014) Ewa Bielska et al.   JOURNAL OF CELL BIOLOGY

FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus

(2014) Xuanli Yao et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule plus end-tracking proteins play critical roles in directional growth of hyphae by regulating the dynamics of cytoplasmic microtubules inAspergillus nidulans

(2014) Cui J. Tracy Zeng et al.   MOLECULAR MICROBIOLOGY

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

Long-distance endosome trafficking drives fungal effector production during plant infection

(2014) Ewa Bielska et al.   Nature Communications

Reconstitution of dynein transport to the microtubule plus end by kinesin

(2014) Anthony J Roberts et al.   eLife

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

Neurospora crassa NKIN2, a Kinesin-3 Motor, Transports Early Endosomes and Is Required for Polarized Growth

(2013) Constanze Seidel et al.   EUKARYOTIC CELL

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs

(2013) Carly I. Dix et al.   JOURNAL OF CELL BIOLOGY

Systematic dissection of dynein regulators in mitosis

(2013) Jonne A. Raaijmakers et al.   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization

(2013) Lu Rao et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies

(2013) Kuo-Fang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Identification of a Novel Site in the Tail of Dynein Heavy Chain Important for Dynein Functionin Vivo

(2012) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

Kinesin-3 and dynein mediate microtubule-dependent co-transport of mRNPs and endosomes

(2012) S. Baumann et al.   JOURNAL OF CELL SCIENCE

Association of Lis1 with outer arm dynein is modulated in response to alterations in flagellar motility

(2012) Panteleimon Rompolas et al.   MOLECULAR BIOLOGY OF THE CELL

Dynactin's pointed-end complex is a cargo-targeting module

(2012) Ting-Yu Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple modes of cytoplasmic dynein regulation

(2012) Richard B. Vallee et al.   NATURE CELL BIOLOGY

Mutually Exclusive Cytoplasmic Dynein Regulation by NudE-Lis1 and Dynactin

(2011) Richard J. McKenney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

(2011) Eliza Żyłkiewicz et al.   JOURNAL OF CELL BIOLOGY

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction

(2011) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons

(2011) J. P. Pandey et al.   JOURNAL OF NEUROSCIENCE

The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein

(2011) M. Arimoto et al.   JOURNAL OF NEUROSCIENCE

Transient binding of dynein controls bidirectional long-range motility of early endosomes

(2011) Martin Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Roles of the Basic Domain of Dynactin p150 in Microtubule Plus-End Tracking and Dynein Function

(2011) Xuanli Yao et al.   TRAFFIC

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Linking molecular motors to membrane cargo

(2010) Anna Akhmanova et al.   CURRENT OPINION IN CELL BIOLOGY

Interaction of the Aspergillus nidulans Microtubule-Organizing Center (MTOC) Component ApsB with Gamma-Tubulin and Evidence for a Role of a Subclass of Peroxisomes in the Formation of Septal MTOCs

(2010) Nadine Zekert et al.   EUKARYOTIC CELL

Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation

(2010) Takayuki Torisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Dynein Binding Domain in Nudel Essential for Spindle Pole Organization inXenopusEgg Extract

(2010) Shusheng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

(2010) C. Lam et al.   JOURNAL OF CELL SCIENCE

The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation

(2010) J. Zhang et al.   JOURNAL OF CELL SCIENCE

A cytoplasmic dynein tail mutation impairs motor processivity

(2010) Kassandra M. Ori-McKenney et al.   NATURE CELL BIOLOGY

CLIP-170-Dependent Capture of Membrane Organelles by Microtubules Initiates Minus-End Directed Transport

(2009) Alexis J. Lomakin et al.   DEVELOPMENTAL CELL

In vivo analysis of the functions of  -tubulin-complex proteins

(2009) Y. Xiong et al.   JOURNAL OF CELL SCIENCE

Organization and Dynamics of the Aspergillus nidulans Golgi during Apical Extension and Mitosis

(2009) Areti Pantazopoulou et al.   MOLECULAR BIOLOGY OF THE CELL

Requirement for Nudel and dynein for assembly of the lamin B spindle matrix

(2009) Li Ma et al.   NATURE CELL BIOLOGY

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nudel Promotes Axonal Lysosome Clearance and Endo-lysosome Formation via Dynein-Mediated Transport

(2009) Qiangge Zhang et al.   TRAFFIC

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL

An FTS/Hook/p107FHIP Complex Interacts with and Promotes Endosomal Clustering by the Homotypic Vacuolar Protein Sorting Complex

(2008) Lai Xu et al.   MOLECULAR BIOLOGY OF THE CELL

The Aspergillus nidulans Kinesin-3 UncA Motor Moves Vesicles along a Subpopulation of Microtubules

(2008) Nadine Zekert et al.   MOLECULAR BIOLOGY OF THE CELL

Dynactin Function in Mitotic Spindle Positioning

(2008) Jeffrey K. Moore et al.   TRAFFIC

Long-Distance Movement of Aspergillus nidulans Early Endosomes on Microtubule Tracks

(2008) Juan F. Abenza et al.   TRAFFIC

Arp11 Affects Dynein–Dynactin Interaction and is Essential for Dynein Function in Aspergillus nidulans

(2008) Jun Zhang et al.   TRAFFIC

Genetic evidence for a microtubule-destabilizing 
effect of conventional kinesin and analysis of its consequences for the control of nuclear distribution 
in Aspergillus nidulans

(2003) Natalia Requena et al.   MOLECULAR MICROBIOLOGY