A kinesin-1 variant reveals motor-induced microtubule damage in cells

Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography

(2022) Joseph Atherton et al.   JOURNAL OF CELL SCIENCE

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

(2021) Breane G. Budaitis et al.   JOURNAL OF CELL BIOLOGY

Self-repair protects microtubules from destruction by molecular motors

(2021) Sarah Triclin et al.   NATURE MATERIALS

Structural snapshots of the kinesin‐2 OSM‐3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism

(2021) Paloma F. Varela et al.   FEBS Open Bio

Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

(2021) Rebecca R. Goldblum et al.   DEVELOPMENTAL CELL

Motor usage imprints microtubule stability along the shaft

(2021) Mireia Andreu-Carbó et al.   DEVELOPMENTAL CELL

Breaking of buckled microtubules is mediated by kinesins

(2020) Arif Md. Rashedul Kabir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation

(2020) Amol Aher et al.   CURRENT BIOLOGY

These motors were made for walking

(2020) Byron Hunter et al.   PROTEIN SCIENCE

Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue

(2020) Hélène Henrie et al.   JOURNAL OF CELL BIOLOGY

How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1

(2020) Jingyu Qin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominate one-head-bound state during its chemomechanical cycle

(2020) Taylor Mae Zaniewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule self-repair

(2020) Manuel Théry et al.   CURRENT OPINION IN CELL BIOLOGY

4.5 Å Cryo-EM Structure of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance

(2019) Ottilie von Loeffelholz et al.   JOURNAL OF MOLECULAR BIOLOGY

Intracellular cargo transport by single-headed kinesin motors

(2019) Kristin I. Schimert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fine structure and dynamics of EB3 binding zones on microtubules in fibroblast cells

(2019) V. V. Mustyatsa et al.   MOLECULAR BIOLOGY OF THE CELL

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

(2019) Breane G Budaitis et al.   eLife

Lattice defects induce microtubule self-renewal

(2019) Laura Schaedel et al.   Nature Physics

Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins

(2019) Wonmuk Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology

(2019) Ines Hahn et al.   Neural Development

Processive Kinesin-14 HSET Exhibits Directional Flexibility Depending on Motor Traffic

(2018) Dana N. Reinemann et al.   CURRENT BIOLOGY

Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement

(2018) Jinqi Ren et al.   JOURNAL OF MOLECULAR BIOLOGY

Human CLASP2 specifically regulates microtubule catastrophe and rescue

(2018) Elizabeth J. Lawrence et al.   MOLECULAR BIOLOGY OF THE CELL

Kinesin expands and stabilizes the GDP-microtubule lattice

(2018) Daniel R. Peet et al.   Nature Nanotechnology

Microtubule architecture in vitro and in cells revealed by cryo-electron tomography

(2018) Joseph Atherton et al.   Acta Crystallographica Section D-Structural Biology

Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation

(2018) Annapurna Vemu et al.   SCIENCE

Parts list for a microtubule depolymerising kinesin

(2018) Claire T. Friel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Kinesin-binding–triggered conformation switching of microtubules contributes to polarized transport

(2018) Tomohiro Shima et al.   JOURNAL OF CELL BIOLOGY

Characterization of microtubule buckling in living cells

(2017) Carla Pallavicini et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Tubulin acetylation protects long-lived microtubules against mechanical ageing

(2017) Didier Portran et al.   NATURE CELL BIOLOGY

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

(2017) Thomas S. Randall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

(2017) Zhenjie Xu et al.   SCIENCE

Kinesin motility driven by subdomain dynamics

(2017) Wonmuk Hwang et al.   eLife

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

(2017) Joseph Atherton et al.   eLife

Localized Mechanical Stress Promotes Microtubule Rescue

(2016) Hélène de Forges et al.   CURRENT BIOLOGY

Kinesin-1 motors can increase the lifetime of taxol-stabilized microtubules

(2016) Cordula Reuther et al.   Nature Nanotechnology

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

(2016) P. Robison et al.   SCIENCE

Engineered kinesin motor proteins amenable to small-molecule inhibition

(2016) Martin F. Engelke et al.   Nature Communications

Transient Pinning and Pulling: A Mechanism for Bending Microtubules

(2016) Ian A. Kent et al.   PLoS One

Mechanical splitting of microtubules into protofilament bundles by surface-bound kinesin-1

(2016) Virginia VanDelinder et al.   Scientific Reports

Influence of Fluorescent Tag on the Motility Properties of Kinesin-1 in Single-Molecule Assays

(2015) Stephen R. Norris et al.   BIOPHYSICAL JOURNAL

X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding

(2015) M. Morikawa et al.   EMBO JOURNAL

Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases

(2015) Nobutaka Hirokawa et al.   EXPERIMENTAL CELL RESEARCH

Molecular wear of microtubules propelled by surface-adhered kinesins

(2015) Emmanuel L. P. Dumont et al.   Nature Nanotechnology

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

(2014) Adeline Goulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization of mammalian kinesin-3 motors results in superprocessive motion

(2014) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

(2014) Joseph Atherton et al.   eLife

Modular Aspects of Kinesin Force Generation Machinery

(2013) William R. Hesse et al.   BIOPHYSICAL JOURNAL

MAP65/Ase1 promote microtubule flexibility

(2013) D. Portran et al.   MOLECULAR BIOLOGY OF THE CELL

The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

(2012) Adeline Goulet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Luminal Localization of α-tubulin K40 Acetylation by Cryo-EM Analysis of Fab-Labeled Microtubules

(2012) Virupakshi Soppina et al.   PLoS One

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape

(2010) A. L. Jolly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3β phosphorylation modulates CLASP–microtubule association and lamella microtubule attachment

(2009) Praveen Kumar et al.   JOURNAL OF CELL BIOLOGY

Anterograde Microtubule Transport Drives Microtubule Bending in LLC-PK1 Epithelial Cells

(2009) Andrew D. Bicek et al.   MOLECULAR BIOLOGY OF THE CELL

Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

(2009) Jennetta W Hammond et al.   PLOS BIOLOGY

Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors

(2009) Dawen Cai et al.   PLOS BIOLOGY

Kinesin's cover-neck bundle folds forward to generate force

(2008) A. S. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation

(2008) Wonmuk Hwang et al.   STRUCTURE