A CRMP4‐dependent retrograde axon‐to‐soma death signal in amyotrophic lateral sclerosis

CRMP 2 mediates Sema3F‐dependent axon pruning and dendritic spine remodeling

(2020) Jakub Ziak et al.   EMBO REPORTS

c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling

(2019) C. A. Escudero et al.   Scientific Reports

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration

(2018) Michael Siu et al.   JOURNAL OF MEDICINAL CHEMISTRY

miR126-5p down-regulation facilitates axon degeneration and NMJ disruption via a non-cell-autonomous mechanism in ALS

(2018) Roy Maimon et al.   JOURNAL OF NEUROSCIENCE

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

(2018) Roberta Cagnetta et al.   NEURON

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

(2018) Katherine L. Gibbs et al.   Cell Death & Disease

Abnormal RNA stability in amyotrophic lateral sclerosis

(2018) E. M. Tank et al.   Nature Communications

Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1

(2018) Amrita Pathak et al.   DEVELOPMENTAL CELL

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

(2018) Mara A. Olenick et al.   JOURNAL OF CELL BIOLOGY

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

(2018) Roberta Cagnetta et al.   MOLECULAR CELL

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

(2017) Kurt J. De Vos et al.   NEUROBIOLOGY OF DISEASE

Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience

(2017) Marco Terenzio et al.   NEURON

Spatial-specific functions in retrograde neuronal signalling

(2017) Eitan Erez Zahavi et al.   TRAFFIC

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models

(2017) Nimrod Rotem et al.   Scientific Reports

Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons

(2016) Amanda B. Wehner et al.   DEVELOPMENT

Compartmental microfluidic system for studying muscle–neuron communication and neuromuscular junction maintenance

(2016) Ariel Ionescu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury

(2016) Jun Nagai et al.   MOLECULAR NEUROBIOLOGY

A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions

(2015) E. E. Zahavi et al.   JOURNAL OF CELL SCIENCE

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation

(2015) Jun Nagai et al.   Scientific Reports

Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS

(2015) Karyn Meltz Steinberg et al.   Scientific Reports

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

(2015) Martin Balastik et al.   Cell Reports

Neuronal Signaling through Endocytosis

(2014) K. E. Cosker et al.   Cold Spring Harbor Perspectives in Biology

Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder

(2014) Rajesh Ponnusamy et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

(2014) Elizabeth B. Moloney et al.   Frontiers in Neuroscience

A Rare Motor Neuron Deleterious Missense Mutation in theDPYSL3(CRMP4) Gene is Associated with ALS

(2013) Hélène Blasco et al.   HUMAN MUTATION

Long-distance retrograde neurotrophic factor signalling in neurons

(2013) Anthony W. Harrington et al.   NATURE REVIEWS NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Differing Semaphorin 3A Concentrations Trigger Distinct Signaling Mechanisms in Growth Cone Collapse

(2012) R. P. C. Manns et al.   JOURNAL OF NEUROSCIENCE

Collapsin Response Mediator Proteins Regulate Neuronal Development and Plasticity by Switching Their Phosphorylation Status

(2012) Naoya Yamashita et al.   MOLECULAR NEUROBIOLOGY

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Shared Resistance to Aging and ALS in Neuromuscular Junctions of Specific Muscles

(2012) Gregorio Valdez et al.   PLoS One

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Collapsin Response Mediator Protein-2 (Crmp2) Regulates Trafficking by Linking Endocytic Regulatory Proteins to Dynein Motors

(2010) Juliati Rahajeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17

(2010) Rajappa S. Kenchappa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

(2010) Nichole A. Reyes et al.   JOURNAL OF CLINICAL INVESTIGATION

Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death

(2010) L. Duplan et al.   JOURNAL OF NEUROSCIENCE

ProNGF Induces PTEN via p75NTR to Suppress Trk-Mediated Survival Signaling in Brain Neurons

(2010) W. Song et al.   JOURNAL OF NEUROSCIENCE

Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor

(2010) So Young Jang et al.   NEUROSCIENCE LETTERS

miRNA malfunction causes spinal motor neuron disease

(2010) S. Haramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrograde axonal transport: pathways to cell death?

(2010) Eran Perlson et al.   TRENDS IN NEUROSCIENCES

CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity

(2009) Nariko Arimura et al.   JOURNAL OF NEUROCHEMISTRY

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Electrodiagnostic criteria for diagnosis of ALS

(2008) Mamede de Carvalho et al.   CLINICAL NEUROPHYSIOLOGY

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS

Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

(2008) Karun K Singh et al.   NATURE NEUROSCIENCE