Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity

Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7

(2022) Luke S. Ferro et al.   SCIENCE

Coiled‐coil registry shifts in the F684I mutant of Bicaudal D result in cargo‐independent activation of dynein motility

(2020) Heying Cui et al.   TRAFFIC

Cargo-Mediated Activation of Cytoplasmic Dynein in vivo

(2020) Xin Xiang et al.   Frontiers in Cell and Developmental Biology

MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

(2019) Xingxiu Pan et al.   Cell Reports

MAP7 family proteins regulate kinesin-1 recruitment and activation

(2019) Peter Jan Hooikaas et al.   JOURNAL OF CELL BIOLOGY

Motor–cargo adaptors at the organelle–cytoskeleton interface

(2019) Jessica A Cross et al.   CURRENT OPINION IN CELL BIOLOGY

The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C

(2019) Alison E. Twelvetrees et al.   JOURNAL OF CELL SCIENCE

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

(2018) Michael T. Kelliher et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

Competition between microtubule-associated proteins directs motor transport

(2018) Brigette Y. Monroy et al.   Nature Communications

MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport

(2018) Stephen R Tymanskyj et al.   eLife

Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

(2018) Stefano Pernigo et al.   eLife

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1

(2016) Alison E. Twelvetrees et al.   NEURON

The light chains of kinesin-1 are autoinhibited

(2016) Yan Y. Yip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

(2014) M. H. Wilson et al.   DEVELOPMENT

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Involvement of the kinesin family membersKIF4AandKIF5Cin intellectual disability and synaptic function

(2014) Marjolein H Willemsen et al.   JOURNAL OF MEDICAL GENETICS

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Structural insights into LINC complexes

(2013) Brian A Sosa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein

(2013) Y. Liu et al.   GENES & DEVELOPMENT

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Kinesin tail domains are intrinsically disordered

(2013) Mark A. Seeger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Basis for Kinesin-1:Cargo Recognition

(2013) S. Pernigo et al.   SCIENCE

MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function

(2012) Thomas Metzger et al.   NATURE

A Small Peptide Sequence is Sufficient for Initiating Kinesin-1 Activation Through Part of TPR Region of KLC1

(2012) Takanori Kawano et al.   TRAFFIC

Kinesin Assembly and Movement in Cells

(2011) Kristen J. Verhey et al.   Annual Review of Biophysics

Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2

(2011) C Crimella et al.   CLINICAL GENETICS

Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility

(2011) Faneng Sun et al.   EMBO JOURNAL

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

(2011) H. Y. K. Kaan et al.   SCIENCE

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding

(2009) Takahide Kon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Ensconsin Promotes Productive Recruitment of Kinesin-1 to Microtubules

(2008) Hsin-Ho Sung et al.   DEVELOPMENTAL CELL

The kinesin-1 motor protein is regulated by a direct interaction of its head and tail

(2008) Kristen A. Dietrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Functional Role of Dynein's Microtubule-Binding Domain

(2008) A. P. Carter et al.   SCIENCE