Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528

(2019) Dail E. Chapman et al.   Nature Communications

Directionality of dynein is controlled by the angle and length of its stalk

(2019) Sinan Can et al.   NATURE

Molecular mechanism of cytoplasmic dynein tension sensing

(2019) Lu Rao et al.   Nature Communications

Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction

(2019) Matthew G Marzo et al.   eLife

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

Label-free high-speed wide-field imaging of single microtubules using interference reflection microscopy

(2018) MOHAMMED MAHAMDEH et al.   JOURNAL OF MICROSCOPY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia

(2018) Mareike A. Jordan et al.   NATURE CELL BIOLOGY

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain

(2017) Kari H. Ecklund et al.   Nature Communications

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

(2016) Florian Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

(2016) Babu J. N. Reddy et al.   Nature Communications

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy

(2015) M. Scoto et al.   NEUROLOGY

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules

(2015) Hiroshi Imai et al.   Nature Communications

Short Synthetic Terminators for Improved Heterologous Gene Expression in Yeast

(2015) Kathleen A. Curran et al.   ACS Synthetic Biology

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

(2014) Gregory M. Alushin et al.   CELL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

A Chimeric Kinesin-1 Head/Kinesin-5 Tail Motor Switches between Diffusive and Processive Motility

(2013) Christina Thiede et al.   BIOPHYSICAL JOURNAL

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs

(2013) Carly I. Dix et al.   JOURNAL OF CELL BIOLOGY

Systematic dissection of dynein regulators in mitosis

(2013) Jonne A. Raaijmakers et al.   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Mutations inDYNC1H1cause severe intellectual disability with neuronal migration defects

(2012) Marjolein H Willemsen et al.   JOURNAL OF MEDICAL GENETICS

Insights into dynein motor domain function from a 3.3-Å crystal structure

(2012) Helgo Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Microtubule Binding and Release by Dynein

(2012) W. B. Redwine et al.   SCIENCE

Quantitative analysis of Pac1/LIS1-mediated dynein targeting: Implications for regulation of dynein activity in budding yeast

(2011) Steven M. Markus et al.   Cytoskeleton

Regulated Offloading of Cytoplasmic Dynein from Microtubule Plus Ends to the Cortex

(2011) Steven M. Markus et al.   DEVELOPMENTAL CELL

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of the Dynein Motor Domain

(2011) A. P. Carter et al.   SCIENCE

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Motor- and Tail-Dependent Targeting of Dynein to Microtubule Plus Ends and the Cell Cortex

(2009) Steven M. Markus et al.   CURRENT BIOLOGY

Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding

(2009) Takahide Kon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin

(2009) J. R. Kardon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL

Dynactin Function in Mitotic Spindle Positioning

(2008) Jeffrey K. Moore et al.   TRAFFIC

Do zwitterions contribute to the ionic strength of a solution?

(2007) Earle Stellwagen et al.   ANALYTICAL BIOCHEMISTRY