Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Conformational diversity of dynactin sidearm and domain organization of its subunit p150

(2020) Kei Saito et al.   MOLECULAR BIOLOGY OF THE CELL

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

An integrated workflow for crosslinking mass spectrometry

(2019) Marta L Mendes et al.   Molecular Systems Biology

Methods for merging data sets in electron cryo-microscopy

(2019) Max E. Wilkinson et al.   Acta Crystallographica Section D-Structural Biology

Metal binding properties, stability and reactivity of zinc fingers

(2018) Katarzyna Kluska et al.   COORDINATION CHEMISTRY REVIEWS

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

(2018) Carlos Sacristan et al.   NATURE CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Current approaches for the fitting and refinement of atomic models into cryo-EM maps using CCP-EM

(2018) Robert A. Nicholls et al.   Acta Crystallographica Section D-Structural Biology

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation

(2018) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Probing the Energetics of Dynactin Filament Assembly and the Binding of Cargo Adaptor Proteins Using Molecular Dynamics Simulation and Electrostatics-Based Structural Modeling

(2016) Wenjun Zheng   BIOCHEMISTRY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry

(2015) Shin-ichi Terawaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

A Structural and Functional Analysis of the Dynein Light Intermediate Chain

(2015) Courtney M. Schroeder et al.   BIOPHYSICAL JOURNAL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

A PIK3C3–Ankyrin-B–Dynactin pathway promotes axonal growth and multiorganelle transport

(2014) Damaris Nadia Lorenzo et al.   JOURNAL OF CELL BIOLOGY

HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

(2014) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes

(2014) K. Li et al.   JOURNAL OF CELL SCIENCE

Dynactin 3D Structure: Implications for Assembly and Dynein Binding

(2014) Hiroshi Imai et al.   JOURNAL OF MOLECULAR BIOLOGY

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

Dynactin integrity depends upon direct binding of dynamitin to Arp1

(2014) Frances Ka Yan Cheong et al.   MOLECULAR BIOLOGY OF THE CELL

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport

(2014) Suvranta K. Tripathy et al.   NATURE CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements

(2014) Max A. Schlager et al.   Cell Reports

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit

(2013) Ting-Yu Yeh et al.   EMBO JOURNAL

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein

(2012) Björn Hammesfahr et al.   BMC EVOLUTIONARY BIOLOGY

Dynactin's pointed-end complex is a cargo-targeting module

(2012) Ting-Yu Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction

(2011) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150Glued and DNC-2/dynamitin

(2010) Masahiro Terasawa et al.   GENES TO CELLS

Ankyrin-B Interactions with Spectrin and Dynactin-4 Are Required for Dystrophin-based Protection of Skeletal Muscle from Exercise Injury

(2010) Gai Ayalon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport

(2009) Zhi Hong et al.   CELL RESEARCH

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Function of dynein in budding yeast: Mitotic spindle positioning in a polarized cell

(2009) Jeffrey K. Moore et al.   CELL MOTILITY AND THE CYTOSKELETON

The Saccharomyces cerevisiae Homolog of p24 Is Essential for Maintaining the Association of p150Glued With the Dynactin Complex

(2008) I. A. Amaro et al.   GENETICS

Physical Basis of Structural and Catalytic Zn-Binding Sites in Proteins

(2008) Yu-ming Lee et al.   JOURNAL OF MOLECULAR BIOLOGY