Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport

Structural basis for cytoplasmic dynein-1 regulation by Lis1

(2022) John P Gillies et al.   eLife

Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

(2021) Yifan Zhang et al.   STRUCTURE

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

(2020) Matthew G. Marzo et al.   NATURE CELL BIOLOGY

New insights into the mechanism of dynein motor regulation by lissencephaly-1

(2020) Steven M Markus et al.   eLife

Nuclear crowding and nonlinear diffusion during interkinetic nuclear migration in the zebrafish retina

(2020) Afnan Azizi et al.   eLife

Role of NDE1 in the Development and Evolution of the Gyrified Cortex

(2020) Jaseph Soto-Perez et al.   Frontiers in Neuroscience

Phenotypic spectrum of NDE1 -related disorders: from microlissencephaly to microhydranencephaly

(2019) Mohamed S. Abdel-Hamid et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Gene expression across mammalian organ development

(2019) Margarida Cardoso-Moreira et al.   NATURE

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance

(2019) Jin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase

(2018) Caitlin L. Wynne et al.   JOURNAL OF CELL BIOLOGY

Nde1 promotes diverse dynein functions through differential interactions and exhibits an isoform-specific proteasome association

(2018) Julie K. Monda et al.   MOLECULAR BIOLOGY OF THE CELL

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo

(2017) Patrícia A. Simões et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation

(2017) Zhen-Yu She et al.   JOURNAL OF CELL SCIENCE

Nuclear migration in mammalian brain development

(2017) Chiara Bertipaglia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay between Phosphorylation Site and Disordered Spliced Linkers

(2017) Jing Jie et al.   STRUCTURE

CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons

(2017) Eva Klinman et al.   TRAFFIC

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

(2016) Marijn Kuijpers et al.   NEURON

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

(2016) Babu J. N. Reddy et al.   Nature Communications

Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages

(2016) David J. Doobin et al.   Nature Communications

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length

(2015) D. Maskey et al.   EMBO JOURNAL

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

(2015) Eva Klinman et al.   Cell Reports

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

(2015) Joanna Lipka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation

(2014) Shauna L Houlihan et al.   eLife

Deletion 16p13.11 uncoversNDE1mutations on the non-deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption

(2013) Alex R. Paciorkowski et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Analysis of copy number variations at 15 schizophrenia-associated loci

(2013) Elliott Rees et al.   BRITISH JOURNAL OF PSYCHIATRY

LIS1 functions in normal development and disease

(2013) Orly Reiner et al.   CURRENT OPINION IN NEUROBIOLOGY

LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex

(2013) Hyang Mi Moon et al.   HUMAN MOLECULAR GENETICS

Intracellular position of G2/M-phase nuclei in neoplastic and non-neoplastic pseudostratified glands suggests the occurrence of interkinetic nuclear migration

(2013) Takashi Kishimoto et al.   Medical Molecular Morphology

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Male-Biased Autosomal Effect of 16p13.11 Copy Number Variation in Neurodevelopmental Disorders

(2013) Maria Tropeano et al.   PLoS One

Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction

(2013) Amanda E. Siglin et al.   PLoS One

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

(2012) Dheeraj Malhotra et al.   CELL

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis

(2012) P. Sitaram et al.   DEVELOPMENT

Intrinsic Disorder in Dynein Intermediate Chain Modulates Its Interactions with NudE and Dynactin

(2012) Afua Nyarko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution

(2012) Dinesh C. Soares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly

(2012) Ayse Guven et al.   NEUROGENETICS

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness

(2011) Dinesh C. Soares et al.   ACS Chemical Neuroscience

The Essential Role of Centrosomal NDE1 in Human Cerebral Cortex Neurogenesis

(2011) Mehmet Bakircioglu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly

(2011) Fowzan S. Alkuraya et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia

(2011) Emily J. Meyer et al.   CURRENT BIOLOGY

Apical migration of nuclei during G2 is a prerequisite for all nuclear motion in zebrafish neuroepithelia

(2011) L. Leung et al.   DEVELOPMENT

Mutually Exclusive Cytoplasmic Dynein Regulation by NudE-Lis1 and Dynactin

(2011) Richard J. McKenney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

(2011) Eliza Żyłkiewicz et al.   JOURNAL OF CELL BIOLOGY

A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase

(2011) Stéphanie Bolhy et al.   JOURNAL OF CELL BIOLOGY

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1

(2011) N. J. Bradshaw et al.   JOURNAL OF NEUROSCIENCE

A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons

(2011) J. P. Pandey et al.   JOURNAL OF NEUROSCIENCE

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry

(2011) Sehyun Kim et al.   NATURE CELL BIOLOGY

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

DISCopathies: Brain Disorders Related to DISC1 Dysfunction

(2011) C. Korth   REVIEWS IN THE NEUROSCIENCES

Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes

(2010) Erin L. Heinzen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

(2010) R. Gassmann et al.   GENES & DEVELOPMENT

Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation

(2010) Takayuki Torisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Dynein Binding Domain in Nudel Essential for Spindle Pole Organization inXenopusEgg Extract

(2010) Shusheng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

(2010) C. Lam et al.   JOURNAL OF CELL SCIENCE

Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells

(2010) Jin-Wu Tsai et al.   NATURE NEUROSCIENCE

Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

(2010) Daniël Splinter et al.   PLOS BIOLOGY

Genome-Wide Copy Number Variation in Epilepsy: Novel Susceptibility Loci in Idiopathic Generalized and Focal Epilepsies

(2010) Heather C. Mefford et al.   PLoS Genetics

Motor- and Tail-Dependent Targeting of Dynein to Microtubule Plus Ends and the Cell Cortex

(2009) Steven M. Markus et al.   CURRENT BIOLOGY

Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity

(2009) Anat Shmueli et al.   EMBO JOURNAL

Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

(2009) George Kirov et al.   HUMAN MOLECULAR GENETICS

Opposing effects of Ndel1 and  1 or  2 on cytoplasmic dynein through competitive binding to Lis1

(2009) C. Ding et al.   JOURNAL OF CELL SCIENCE

Roles of the Drosophila NudE protein in kinetochore function and centrosome migration

(2009) A. Wainman et al.   JOURNAL OF CELL SCIENCE

Distinct Dose-Dependent Cortical Neuronal Migration and Neurite Extension Defects in Lis1 and Ndel1 Mutant Mice

(2009) Y. H. Youn et al.   JOURNAL OF NEUROSCIENCE

Copy number variations of chromosome 16p13.1 region associated with schizophrenia

(2009) A Ingason et al.   MOLECULAR PSYCHIATRY

Requirement for Nudel and dynein for assembly of the lamin B spindle matrix

(2009) Li Ma et al.   NATURE CELL BIOLOGY

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient

(2008) Filippo Del Bene et al.   CELL

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding

(2008) K. E. Burdick et al.   HUMAN MOLECULAR GENETICS

Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells

(2008) Sachin Hebbar et al.   JOURNAL OF CELL BIOLOGY

Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant

(2008) F D Hannes et al.   JOURNAL OF MEDICAL GENETICS

NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

(2008) Nicholas J. Bradshaw et al.   NEUROSCIENCE LETTERS

Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics

(2008) Nobutaka Hirokawa et al.   PHYSIOLOGICAL REVIEWS