Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

Mechanisms of neurotrophin trafficking via Trk receptors

(2018) Emily Scott-Solomon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

(2018) Mengchen Ye et al.   eLife

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin

(2017) Walter Huynh et al.   JOURNAL OF CELL BIOLOGY

The human cytoplasmic dynein interactome reveals novel activators of motility

(2017) William B Redwine et al.   eLife

Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease

(2017) Fang Fang et al.   Scientific Reports

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

(2016) M. Mitre et al.   CLINICAL SCIENCE

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

(2016) Xiaoli Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry

(2015) Shin-ichi Terawaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport

(2015) Mariko Matsuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hook Proteins: Association with Alzheimer Pathology and Regulatory Role of Hook3 in Amyloid Beta Generation

(2015) Lydia Herrmann et al.   PLoS One

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

(2014) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

(2014) Ewa Bielska et al.   JOURNAL OF CELL BIOLOGY

FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus

(2014) Xuanli Yao et al.   MOLECULAR BIOLOGY OF THE CELL

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

Neuronal Signaling through Endocytosis

(2014) K. E. Cosker et al.   Cold Spring Harbor Perspectives in Biology

Dynactin functions as both a dynamic tether and brake during dynein-driven motility

(2014) Swathi Ayloo et al.   Nature Communications

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1

(2013) Lymarie Maldonado-Báez et al.   JOURNAL OF CELL BIOLOGY

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Dynactin's pointed-end complex is a cargo-targeting module

(2012) Ting-Yu Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

Snapin Recruits Dynein to BDNF-TrkB Signaling Endosomes for Retrograde Axonal Transport and Is Essential for Dendrite Growth of Cortical Neurons

(2012) Bing Zhou et al.   Cell Reports

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction

(2011) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Self-amplifying autocrine actions of BDNF in axon development

(2011) P.-L. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

(2010) Max A Schlager et al.   EMBO JOURNAL

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

(2009) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Murine CENP-F Regulates Centrosomal Microtubule Nucleation and Interacts with Hook2 at the Centrosome

(2009) Katherine L. Moynihan et al.   MOLECULAR BIOLOGY OF THE CELL

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An FTS/Hook/p107FHIP Complex Interacts with and Promotes Endosomal Clustering by the Homotypic Vacuolar Protein Sorting Complex

(2008) Lai Xu et al.   MOLECULAR BIOLOGY OF THE CELL