ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function

Human cerebral organoids reveal progenitor pathology in EML1‐linked cortical malformation

(2022) Ammar Jabali et al.   EMBO REPORTS

An ALS ‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity

(2022) Juri Nakano et al.   GENES TO CELLS

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function

(2022) Desiree M. Baron et al.   Cell Reports

Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity

(2022) Kyoko Chiba et al.   Cell Reports

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

(2021) Breane G. Budaitis et al.   JOURNAL OF CELL BIOLOGY

A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health

(2021) Aileen J. Lam et al.   Science Advances

Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers

(2021) Francesco Liguori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis.

(2020) Ryoichi Nakamura et al.   NEUROBIOLOGY OF AGING

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

(2020) Arielle N. Valdez-Sinon et al.   iScience

Splice-site mutations in KIF5A in the Japanese case series of amyotrophic lateral sclerosis

(2020) Hiroya Naruse et al.   NEUROGENETICS

Identification of a pathogenic intronic KIF5A mutation in an ALS-FTD kindred

(2020) Sara Saez-Atienzar et al.   NEUROLOGY

Role and therapeutic potential of liquid‒liquid phase separation in amyotrophic lateral sclerosis

(2020) Donya Pakravan et al.   Journal of Molecular Cell Biology

Intrafamilial variable spastic paraplegia/ataxia/ALS phenotype linked to a novel KIF5A mutation

(2019) Mohammed Faruq et al.   CLINICAL GENETICS

Update on amyotrophic lateral sclerosis genetics

(2019) David Brenner et al.   CURRENT OPINION IN NEUROLOGY

Whole-exome sequencing identified novel KIF5A mutations in Chinese patients with amyotrophic lateral sclerosis and Charcot-Marie-Tooth type 2

(2019) Jing He et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions

(2019) Ki-Seo Yoo et al.   Molecular Brain

Hot-spot KIF5A mutations cause familial ALS

(2018) David Brenner et al.   BRAIN

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Mutation analysis of KIF5A in Chinese amyotrophic lateral sclerosis patients

(2018) Kang Zhang et al.   NEUROBIOLOGY OF AGING

Kinesin-binding–triggered conformation switching of microtubules contributes to polarized transport

(2018) Tomohiro Shima et al.   JOURNAL OF CELL BIOLOGY

KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis

(2017) Hirotoshi Kamata et al.   Scientific Reports

KIF5Amutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction

(2016) Jessica Duis et al.   ANNALS OF NEUROLOGY

The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus

(2016) William O. Hancock   BIOPHYSICAL JOURNAL

KIF5A de novomutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy

(2016) M. Rydzanicz et al.   CLINICAL GENETICS

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Generation and characterization of an induced pluripotent stem cell (iPSC) line from a patient with clozapine-resistant Schizophrenia

(2016) Fabio Marsoner et al.   Stem Cell Research

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

(2015) Zhong-Wei Du et al.   Nature Communications

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2

(2011) C Crimella et al.   CLINICAL GENETICS

Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

(2011) H. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

(2011) H. Y. K. Kaan et al.   SCIENCE

Microtubule-associated Protein-like Binding of the Kinesin-1 Tail to Microtubules

(2010) Mark A. Seeger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Half-Site Inhibition of Dimeric Kinesin Head Domains by Monomeric Tail Domains†

(2009) David D. Hackney et al.   BIOCHEMISTRY

Walking the walk: how kinesin and dynein coordinate their steps

(2009) Arne Gennerich et al.   CURRENT OPINION IN CELL BIOLOGY

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity

(2008) Bettina Ebbing et al.   HUMAN MOLECULAR GENETICS

The kinesin-1 motor protein is regulated by a direct interaction of its head and tail

(2008) Kristen A. Dietrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA