Structure of dynein–dynactin on microtubules shows tandem adaptor binding

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Structure of a microtubule-bound axonemal dynein

(2021) Travis Walton et al.   Nature Communications

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks

(2021) Ellen D. Zhong et al.   NATURE METHODS

Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

(2021) Clinton K Lau et al.   EMBO JOURNAL

Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domain

(2021) Rongde Qiu et al.   CURRENT BIOLOGY

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM

(2021) Shintaroh Kubo et al.   EMBO REPORTS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism

(2021) Qinhui Rao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

(2021) Adam R. Fenton et al.   Nature Communications

New tools for automated cryo-EM single-particle analysis in RELION-4.0

(2021) Dari Kimanius et al.   BIOCHEMICAL JOURNAL

EMDA: A Python package for Electron Microscopy Data Analysis

(2021) Rangana Warshamanage et al.   JOURNAL OF STRUCTURAL BIOLOGY

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Two particle-picking procedures for filamentous proteins: SPHIRE-crYOLO filament mode and SPHIRE-STRIPER

(2020) Thorsten Wagner et al.   Acta Crystallographica Section D-Structural Biology

MMseqs2 desktop and local web server app for fast, interactive sequence searches

(2019) M Mirdita et al.   BIOINFORMATICS

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

(2019) Ricardo Celestino et al.   PLOS BIOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

(2019) Samuel E Lacey et al.   eLife

Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

(2019) Mohamed M. Elshenawy et al.   Nature Chemical Biology

Structure of the Decorated Ciliary Doublet Microtubule

(2019) Meisheng Ma et al.   CELL

A microtubule RELION-based pipeline for cryo-EM image processing

(2019) Alexander D. Cook et al.   JOURNAL OF STRUCTURAL BIOLOGY

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

(2018) Carlos Sacristan et al.   NATURE CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

(2018) Mark A McClintock et al.   eLife

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Dynamics of Allosteric Transitions in Dynein

(2018) Yonathan Goldtzvik et al.   STRUCTURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

(2017) Elizabeth H. Kellogg et al.   JOURNAL OF MOLECULAR BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes

(2016) Ashim Rai et al.   CELL

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition

(2016) Vladislav Belyy et al.   NATURE CELL BIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Allosteric Communication in the Dynein Motor Domain

(2014) Gira Bhabha et al.   CELL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

(2014) Ewa Bielska et al.   JOURNAL OF CELL BIOLOGY

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

LOGICOIL—multi-state prediction of coiled-coil oligomeric state

(2012) Thomas L. Vincent et al.   BIOINFORMATICS

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

The 2.8 Å crystal structure of the dynein motor domain

(2012) Takahide Kon et al.   NATURE

Insights into dynein motor domain function from a 3.3-Å crystal structure

(2012) Helgo Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Single Protofilament Is Sufficient to Support Unidirectional Walking of Dynein and Kinesin

(2012) Keitaro Shibata et al.   PLoS One

Structural Basis for Microtubule Binding and Release by Dynein

(2012) W. B. Redwine et al.   SCIENCE

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

(2010) Max A Schlager et al.   EMBO JOURNAL

AAA+ Ring and Linker Swing Mechanism in the Dynein Motor

(2009) Anthony J. Roberts et al.   CELL