Dynein activators and adaptors at a glance

The dynein adaptor Hook2 plays essential roles in mitotic progression and cytokinesis

(2019) Devashish Dwivedi et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

(2018) Thomas E Sladewski et al.   eLife

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

(2018) Mark A McClintock et al.   eLife

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation

(2018) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

(2018) Mara A. Olenick et al.   JOURNAL OF CELL BIOLOGY

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin

(2017) Walter Huynh et al.   JOURNAL OF CELL BIOLOGY

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

The human cytoplasmic dynein interactome reveals novel activators of motility

(2017) William B Redwine et al.   eLife

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Characterization of axonal transport defects in Drosophila Huntingtin mutants

(2016) Kurt R. Weiss et al.   JOURNAL OF NEUROGENETICS

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

(2016) Xiaoli Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry

(2015) Shin-ichi Terawaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling

(2015) Minseok Song et al.   DEVELOPMENTAL CELL

Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons

(2015) Omar Loss et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

(2015) Eva Klinman et al.   Cell Reports

NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish

(2015) Margo Dona et al.   PLoS Genetics

The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking

(2015) Ruxandra Bachmann-Gagescu et al.   PLoS Genetics

NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans

(2015) Shaohe Wang et al.   eLife

Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons

(2014) Yuuki Yazaki et al.   BRAIN RESEARCH

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

(2014) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

(2014) Ewa Bielska et al.   JOURNAL OF CELL BIOLOGY

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements

(2014) Max A. Schlager et al.   Cell Reports

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

Dynein Recruitment to Nuclear Pores Activates Apical Nuclear Migration and Mitotic Entry in Brain Progenitor Cells

(2013) Daniel Jun-Kit Hu et al.   CELL

Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein

(2013) Y. Liu et al.   GENES & DEVELOPMENT

An Organelle Gatekeeper Function forCaenorhabditis elegansUNC-16 (JIP3) at the Axon Initial Segment

(2013) Stacey L. Edwards et al.   GENETICS

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1

(2013) Lymarie Maldonado-Báez et al.   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Distinct Functions of Nuclear Distribution Proteins LIS1, Ndel1 and NudCL in Regulating Axonal Mitochondrial Transport

(2013) Chong-Yu Shao et al.   TRAFFIC

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

(2013) Catherine M. Drerup et al.   PLoS Genetics

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein

(2012) Andrew Dauber et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons

(2012) Gui-Zhi Yang et al.   JOURNAL OF NEUROCHEMISTRY

Dynactin's pointed-end complex is a cargo-targeting module

(2012) Ting-Yu Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

(2011) Eliza Żyłkiewicz et al.   JOURNAL OF CELL BIOLOGY

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction

(2011) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons

(2011) J. P. Pandey et al.   JOURNAL OF NEUROSCIENCE

X-ray structure of a functional full-length dynein motor domain

(2011) Takahide Kon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

(2010) Max A Schlager et al.   EMBO JOURNAL

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

(2010) R. Gassmann et al.   GENES & DEVELOPMENT

Identification of a Novel Dynein Binding Domain in Nudel Essential for Spindle Pole Organization inXenopusEgg Extract

(2010) Shusheng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation

(2010) J. Zhang et al.   JOURNAL OF CELL SCIENCE

Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation

(2010) Marin Barisic et al.   MOLECULAR BIOLOGY OF THE CELL

Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

(2010) Alison E. Twelvetrees et al.   NEURON

The dynamic Rab11-FIPs

(2009) Conor P. Horgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in Cytokinesis

(2009) Guillaume Montagnac et al.   CURRENT BIOLOGY

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

(2009) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles

(2009) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly

(2009) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment

(2009) C. P. Horgan et al.   JOURNAL OF CELL SCIENCE

Murine CENP-F Regulates Centrosomal Microtubule Nucleation and Interacts with Hook2 at the Centrosome

(2009) Katherine L. Moynihan et al.   MOLECULAR BIOLOGY OF THE CELL

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis

(2008) Glenn C Simon et al.   EMBO JOURNAL

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex

(2008) R. Gassmann et al.   GENES & DEVELOPMENT

Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells

(2008) Sachin Hebbar et al.   JOURNAL OF CELL BIOLOGY

Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin

(2008) L.-S. Her et al.   JOURNAL OF NEUROSCIENCE

Arf GTPase-activating Protein ASAP1 Interacts with Rab11 Effector FIP3 and Regulates Pericentrosomal Localization of Transferrin Receptor–positive Recycling Endosome

(2008) Hiroki Inoue et al.   MOLECULAR BIOLOGY OF THE CELL

An FTS/Hook/p107FHIP Complex Interacts with and Promotes Endosomal Clustering by the Homotypic Vacuolar Protein Sorting Complex

(2008) Lai Xu et al.   MOLECULAR BIOLOGY OF THE CELL