JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

(2021) Swetha Gowrishankar et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

(2021) Sydney E. Cason et al.   JOURNAL OF CELL BIOLOGY

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions

(2020) Cristina Renna et al.   STRUCTURE

De Novo Variants in MAPK8IP3 Cause Intellectual Disability with Variable Brain Anomalies

(2019) Konrad Platzer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

(2019) Ricardo Celestino et al.   PLOS BIOLOGY

Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2

(2019) Sarah E. Hill et al.   DEVELOPMENTAL CELL

Recurrent de novo MAPK8IP3 variants cause neurological phenotypes

(2019) Shinya Iwasawa et al.   ANNALS OF NEUROLOGY

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

(2019) Fernando Vilela et al.   Scientific Reports

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport

(2018) Guruprasada Reddy Sure et al.   Scientific Reports

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3

(2018) Joseph J.B. Cockburn et al.   STRUCTURE

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes

(2017) Bikash Choudhary et al.   PLoS Genetics

Keeping Neuronal Cargoes on the Right Track: New Insights into Regulators of Axonal Transport

(2016) Kenneth G. Miller   NEUROSCIENTIST

KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons

(2016) Sylvia Neumann et al.   TRAFFIC

JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration

(2015) T Sato et al.   CELL DEATH AND DIFFERENTIATION

UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons

(2015) S. L. Edwards et al.   GENETICS

JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation

(2015) Dana Watt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans

(2014) Alexandre Paix et al.   GENETICS

Efficient Marker-Free Recovery of Custom Genetic Modifications with CRISPR/Cas9 in Caenorhabditis elegans

(2014) J. A. Arribere et al.   GENETICS

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

An Organelle Gatekeeper Function forCaenorhabditis elegansUNC-16 (JIP3) at the Axon Initial Segment

(2013) Stacey L. Edwards et al.   GENETICS

c-Jun NH2-terminal Kinase (JNK)-interacting Protein-3 (JIP3) Regulates Neuronal Axon Elongation in a Kinesin- and JNK-dependent Manner

(2013) Tao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of cargo recognitions for class V myosins

(2013) Z. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

(2013) Catherine M. Drerup et al.   PLoS Genetics

Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

(2013) Jing Yan et al.   eLife

The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content

(2012) Johanna R. Schaub et al.   MOLECULAR BIOLOGY OF THE CELL

Improved Mos1-mediated transgenesis in C. elegans

(2012) Christian Frøkjær-Jensen et al.   NATURE METHODS

Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility

(2011) Faneng Sun et al.   EMBO JOURNAL

JIP3 Mediates TrkB Axonal Anterograde Transport and Enhances BDNF Signaling by Directly Bridging TrkB with Kinesin-1

(2011) S.-H. Huang et al.   JOURNAL OF NEUROSCIENCE

The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein

(2011) M. Arimoto et al.   JOURNAL OF NEUROSCIENCE

ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in Cytokinesis

(2009) Guillaume Montagnac et al.   CURRENT BIOLOGY

Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles

(2009) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling

(2009) M.-F. Lise et al.   JOURNAL OF CELL SCIENCE

Co-operative Versus Independent Transport of Different Cargoes by Kinesin-1

(2008) Jennetta W. Hammond et al.   TRAFFIC