Structural basis for cytoplasmic dynein-1 regulation by Lis1

Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domain

(2021) Rongde Qiu et al.   CURRENT BIOLOGY

3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

(2021) Ali Punjani et al.   JOURNAL OF STRUCTURAL BIOLOGY

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

(2021) Adam R. Fenton et al.   Nature Communications

Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes

(2021) Jenna R Christensen et al.   eLife

Activation and Regulation of Cytoplasmic Dynein

(2020) John T. Canty et al.   TRENDS IN BIOCHEMICAL SCIENCES

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

(2020) Matthew G. Marzo et al.   NATURE CELL BIOLOGY

New insights into the mechanism of dynein motor regulation by lissencephaly-1

(2020) Steven M Markus et al.   eLife

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Cargo-Mediated Activation of Cytoplasmic Dynein in vivo

(2020) Xin Xiang et al.   Frontiers in Cell and Developmental Biology

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

(2020) Ali Punjani et al.   NATURE METHODS

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids

(2019) Indrajit Lahiri et al.   JOURNAL OF STRUCTURAL BIOLOGY

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

The human cytoplasmic dynein interactome reveals novel activators of motility

(2017) William B Redwine et al.   eLife

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Long shelf-life streptavidin support-films suitable for electron microscopy of biological macromolecules

(2016) Bong-Gyoon Han et al.   JOURNAL OF STRUCTURAL BIOLOGY

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

(2015) Joanna Lipka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Allosteric Communication in the Dynein Motor Domain

(2014) Gira Bhabha et al.   CELL

Function and regulation of dynein in mitotic chromosome segregation

(2014) J. A. Raaijmakers et al.   CHROMOSOMA

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Reconstitution of dynein transport to the microtubule plus end by kinesin

(2014) Anthony J Roberts et al.   eLife

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Electron microscopy of biotinylated protein complexes bound to streptavidin monolayer crystals

(2012) Bong-Gyoon Han et al.   JOURNAL OF STRUCTURAL BIOLOGY

Insights into dynein motor domain function from a 3.3-Å crystal structure

(2012) Helgo Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of the human cytoplasmic dynein complex

(2012) M. Trokter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated Offloading of Cytoplasmic Dynein from Microtubule Plus Ends to the Cortex

(2011) Steven M. Markus et al.   DEVELOPMENTAL CELL

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions

(2010) Grigore D. Pintilie et al.   JOURNAL OF STRUCTURAL BIOLOGY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Motor- and Tail-Dependent Targeting of Dynein to Microtubule Plus Ends and the Cell Cortex

(2009) Steven M. Markus et al.   CURRENT BIOLOGY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL

A new role for kinesin-directed transport of Bik1p (CLIP-170) in Saccharomyces cerevisiae

(2008) F. Caudron et al.   JOURNAL OF CELL SCIENCE