LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

(2020) Matthew G. Marzo et al.   NATURE CELL BIOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

The human cytoplasmic dynein interactome reveals novel activators of motility

(2017) William B Redwine et al.   eLife

Review: Structure and mechanism of the dynein motor ATPase

(2016) Helgo Schmidt et al.   BIOPOLYMERS

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

(2015) Joanna Lipka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Function and regulation of dynein in mitotic chromosome segregation

(2014) J. A. Raaijmakers et al.   CHROMOSOMA

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Reconstitution of dynein transport to the microtubule plus end by kinesin

(2014) Anthony J Roberts et al.   eLife

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs

(2013) Carly I. Dix et al.   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

Reconstitution of the human cytoplasmic dynein complex

(2012) M. Trokter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation

(2010) Takayuki Torisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

(2010) C. Lam et al.   JOURNAL OF CELL SCIENCE

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy

(2009) N.R. Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Function of dynein in budding yeast: Mitotic spindle positioning in a polarized cell

(2009) Jeffrey K. Moore et al.   CELL MOTILITY AND THE CYTOSKELETON

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL