ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function
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Title
ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function
Authors
Keywords
axonal transport, kinesin, KIF5A, neuronal survival, amyotrophic lateral sclerosis, ALS, autoinhibition, neurodegenerative disease
Journal
Cell Reports
Volume 39, Issue 1, Pages 110598
Publisher
Elsevier BV
Online
2022-04-05
DOI
10.1016/j.celrep.2022.110598
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