Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7

(2022) Luke S. Ferro et al.   SCIENCE

Selective motor activation in organelle transport along axons

(2022) Sydney E. Cason et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

(2021) Breane G. Budaitis et al.   JOURNAL OF CELL BIOLOGY

Germanium nanospheres for ultraresolution picotensiometry of kinesin motors

(2021) Swathi Sudhakar et al.   SCIENCE

Integrated multi-wavelength microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

(2021) Daguan Nong et al.   Biomedical Optics Express

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

(2021) Sydney E. Cason et al.   JOURNAL OF CELL BIOLOGY

On and off controls within dynein–dynactin on native cargoes

(2021) Paulomi Sanghavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

(2021) Adam R. Fenton et al.   Nature Communications

A Combinatorial MAP Code Dictates Polarized Microtubule Transport

(2020) Brigette Y. Monroy et al.   DEVELOPMENTAL CELL

Dynein harnesses active fluctuations of microtubules for faster movement

(2020) Yasin Ezber et al.   Nature Physics

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

(2020) Qingzhou Feng et al.   MOLECULAR BIOLOGY OF THE CELL

Backstepping Mechanism of Kinesin-1

(2020) Algirdas Toleikis et al.   BIOPHYSICAL JOURNAL

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominate one-head-bound state during its chemomechanical cycle

(2020) Taylor Mae Zaniewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Load‐dependent detachment kinetics plays a key role in bidirectional cargo transport by kinesin and dynein

(2019) Kazuka G. Ohashi et al.   TRAFFIC

Polyglutamylation of tubulin’s C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A

(2019) Dominique V Lessard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motor Dynamics Underlying Cargo Transport by Pairs of Kinesin-1 and Kinesin-3 Motors

(2019) Göker Arpağ et al.   BIOPHYSICAL JOURNAL

The Orphan Kinesin PAKRP2 Achieves Processive Motility via a Noncanonical Stepping Mechanism

(2019) Allison M. Gicking et al.   BIOPHYSICAL JOURNAL

Force Generated by Two Kinesin Motors Depends on the Load Direction and Intermolecular Coupling

(2019) Hamid Khataee et al.   PHYSICAL REVIEW LETTERS

Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C

(2019) Agnieszka A. Kendrick et al.   JOURNAL OF CELL BIOLOGY

Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

(2019) Mohamed M. Elshenawy et al.   Nature Chemical Biology

Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia

(2019) Dominik R. Gabrych et al.   Frontiers in Cellular Neuroscience

The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C

(2019) Alison E. Twelvetrees et al.   JOURNAL OF CELL SCIENCE

Three Beads Are Better Than One

(2019) Jonathon Howard et al.   BIOPHYSICAL JOURNAL

Modulation of Kinesin’s Load-Bearing Capacity by Force Geometry and the Microtubule Track

(2019) Serapion Pyrpassopoulos et al.   BIOPHYSICAL JOURNAL

Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport

(2018) Qingzhou Feng et al.   BIOPHYSICAL JOURNAL

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes

(2016) Ashim Rai et al.   CELL

The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition

(2016) Vladislav Belyy et al.   NATURE CELL BIOLOGY

The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load

(2015) Johan O.L. Andreasson et al.   CURRENT BIOLOGY

Processivity of the Kinesin-2 KIF3A Results from Rear Head Gating and Not Front Head Gating

(2015) Geng-Yuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle

(2015) Keith J. Mickolajczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Examining kinesin processivity within a general gating framework

(2015) Johan OL Andreasson et al.   eLife

Transport by Populations of Fast and Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important for In Vivo Function

(2014) Göker Arpağ et al.   BIOPHYSICAL JOURNAL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

A method for multiprotein assembly in cells reveals independent action of kinesins in complex

(2014) Stephen R. Norris et al.   JOURNAL OF CELL BIOLOGY

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

In vivo optical trapping indicates kinesin’s stall force is reduced by dynein during intracellular transport

(2013) Benjamin H. Blehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors

(2012) A. G. Hendricks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles

(2011) Sandra E. Encalada et al.   CELL

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport

(2011) A. Kunwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient binding of dynein controls bidirectional long-range motility of early endosomes

(2011) Martin Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors

(2010) Shankar Shastry et al.   CURRENT BIOLOGY

Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport

(2010) Adam G. Hendricks et al.   CURRENT BIOLOGY

Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

(2010) Alison E. Twelvetrees et al.   NEURON

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

(2010) Marta H. Kubala et al.   PROTEIN SCIENCE

Probing Dynein and Kinesin Stepping with Mechanical Manipulation in a Living Cell

(2009) Peter A. Sims et al.   CHEMPHYSCHEM

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes

(2009) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

Retrograde axonal transport and motor neuron disease

(2008) Anna-Lena Strm et al.   JOURNAL OF NEUROCHEMISTRY

Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors

(2008) M. J. I. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Microtubule Motors Move Early and Late Endocytic Compartments

(2008) Sylvain Loubéry et al.   TRAFFIC

Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides

(2007) Rosemarie V. Barkus et al.   MOLECULAR BIOLOGY OF THE CELL