The mechanisms of ferroptosis and its role in alzheimer’s disease

p53 in ferroptosis regulation: the new weapon for the old guardian

(2022) Yanqing Liu et al.   CELL DEATH AND DIFFERENTIATION

Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer’s disease

(2022) Hailong Yan et al.   Scientific Reports

Ferroptosis Biology and Implication in Cancers

(2022) Chi Qu et al.   Frontiers in Molecular Biosciences

Role and mechanism of ferroptosis in neurological diseases

(2022) Mengmeng Ou et al.   Molecular Metabolism

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glutathione: an old and small molecule with great functions and new applications in the brain and in Alzheimer’s disease

(2021) Mohamed Haddad et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor

(2021) Yue Cheng et al.   Oxidative Medicine and Cellular Longevity

The complexity of p53-mediated metabolic regulation in tumor suppression

(2021) Yanqing Liu et al.   SEMINARS IN CANCER BIOLOGY

The diverse functionality of NQO1 and its roles in redox control

(2021) David Ross et al.   Redox Biology

Ferroptosis: Biochemistry and Biology in Cancers

(2021) Zhiyuan Shi et al.   Frontiers in Oncology

Recent progress on targeting ferroptosis for cancer therapy

(2021) Guangxiang Xu et al.   BIOCHEMICAL PHARMACOLOGY

N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells

(2021) Weijia Peng et al.   BRAIN RESEARCH BULLETIN

Molecular mechanisms of cell death in neurological diseases

(2021) Diane Moujalled et al.   CELL DEATH AND DIFFERENTIATION

Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

(2021) Jens V. Andersen et al.   NEUROPHARMACOLOGY

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

(2021) Duygu Ege   Materials

Ferroptosis as a new therapeutic opportunity for nonviral liver disease

(2021) Min Jia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Research progress on the mechanism of ferroptosis and its clinical application

(2021) Jiarui Xia et al.   EXPERIMENTAL CELL RESEARCH

Ferroptosis: The Silver Lining of Cancer Therapy

(2021) Zhengming Tang et al.   Frontiers in Cell and Developmental Biology

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease

(2020) Nao Yan et al.   Frontiers in Neuroscience

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

(2020) Azhaar Ashraf et al.   Redox Biology

Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

(2020) Andrew Tsatsanis et al.   MOLECULAR PSYCHIATRY

Ferroptosis as an emerging target in inflammatory diseases

(2020) Huimin Mao et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway

(2020) Yu Yuan et al.   INFLAMMOPHARMACOLOGY

Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis

(2020) Germán Plascencia-Villa et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer’s Disease

(2020) Azhaar Ashraf et al.   Frontiers in Aging Neuroscience

The Potential Value of Targeting Ferroptosis in Early Brain Injury After Acute CNS Disease

(2020) Junhui Chen et al.   Frontiers in Molecular Neuroscience

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

(2020) Kathleen M. Farmer et al.   Acta Neuropathologica Communications

A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis

(2020) Zhifang Hu et al.   Frontiers in Oncology

Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases

(2020) Fang Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Application of Ferroptosis in Diseases

(2020) Yangmin Qiu et al.   PHARMACOLOGICAL RESEARCH

The importance of BDNF and RAGE in diabetes-induced dementia

(2020) Oh Yoen Kim et al.   PHARMACOLOGICAL RESEARCH

Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

(2020) Ling Huang et al.   Cell Death & Disease

CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease

(2020) Gamze Ates et al.   Redox Biology

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

(2020) Minlin Jiang et al.   Translational Lung Cancer Research

Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease

(2020) Morgan K. Foret et al.   CHEMICAL REVIEWS

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

(2020) Cadiele Oliana Reichert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Supplementation with γ-glutamylcysteine (γ-GC) lessens oxidative stress, brain inflammation and amyloid pathology and improves spatial memory in a murine model of AD

(2020) Yue Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases

(2020) Joseph Johnson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Mechanism and intervention measures of iron side effects on the intestine

(2019) Xiao Qi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

(2019) Qin Li et al.   Frontiers in Pharmacology

Amylin as a potential link between type 2 diabetes and alzheimer disease

(2019) Ivan Martinez‐Valbuena et al.   ANNALS OF NEUROLOGY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective

(2019) Paul J. Derry et al.   PROGRESS IN NEUROBIOLOGY

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

(2018) Caroline Moreau et al.   ANTIOXIDANTS & REDOX SIGNALING

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Multi-Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer’s Disease

(2018) Abhishek Ankur Balmik et al.   JOURNAL OF ALZHEIMERS DISEASE

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

The significance, trafficking and determination of labile iron in cytosol, mitochondria and lysosomes

(2018) Huanhuan Lv et al.   Metallomics

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

(2018) Mami Sato et al.   Scientific Reports

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

(2018) Mingzhu Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr−/− mice

(2018) Mitchell Bijnen et al.   Scientific Reports

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway

(2017) Yue Sun et al.   EXPERIMENTAL CELL RESEARCH

Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models

(2017) Agnese Gugliandolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Theoretical insights into the mechanism of ferroptosis suppression via inactivation of a lipid peroxide radical by liproxstatin-1

(2017) Xiehuang Sheng et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

ALK is a therapeutic target for lethal sepsis

(2017) Ling Zeng et al.   Science Translational Medicine

Vitamin C, Aging and Alzheimer’s Disease

(2017) et al.   Nutrients

Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

(2017) Mélanie H. Thomas et al.   Alzheimers Research & Therapy

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice

(2017) Marco Cascella et al.   Infectious Agents and Cancer

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)

(2017) Richard J. Kryscio et al.   JAMA Neurology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration

(2016) Tommaso Cassano et al.   Current Alzheimer Research

Complete loss of function of the ubiquitin ligase HERC2 causes a severe neurodevelopmental phenotype

(2016) Fanny Morice-Picard et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Glutathione peroxidase 4: a new player in neurodegeneration?

(2016) B R Cardoso et al.   MOLECULAR PSYCHIATRY

Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

(2016) Vladimir Parpura et al.   NEUROCHEMICAL RESEARCH

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

(2016) David Kennedy   Nutrients

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Disturbed Neurotransmitter Transporter Expression in Alzheimer’s Disease Brain

(2016) Kevin H. Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice

(2015) De-Lin Ma et al.   JOURNAL OF NEUROCHEMISTRY

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

R2* mapping for brain iron: associations with cognition in normal aging

(2015) Christine Ghadery et al.   NEUROBIOLOGY OF AGING

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease

(2015) Grzegorz A. Czapski et al.   NEUROCHEMICAL RESEARCH

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer’s Disease Peptide β-Amyloid

(2014) James Everett et al.   INORGANIC CHEMISTRY

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide  -amyloid (1-42)

(2014) J. Everett et al.   Journal of the Royal Society Interface

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Expression and activity of PARP family members in the hippocampus during systemic inflammation: Their role in the regulation of prooxidative genes

(2013) Grzegorz A. Czapski et al.   NEUROCHEMISTRY INTERNATIONAL

Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

(2013) Gwenaëlle Douaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coenzyme Q10 supplementation reverses age-related impairments in spatial learning and lowers protein oxidation

(2012) Ritu A. Shetty et al.   AGE

Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

(2012) Antonio Currais et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease

(2012) Kyunghee Byun et al.   PLoS One

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific iron chelators determine the route of ferritin degradation

(2009) I. De Domenico et al.   BLOOD

Distinct Nrf1/2-independent mechanisms mediate As3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes

(2009) James A. Thompson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

(2008) F. Léveillé et al.   FASEB JOURNAL

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

(2007) Alireza Kashani et al.   NEUROBIOLOGY OF AGING