The complexity of p53-mediated metabolic regulation in tumor suppression

P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future

(2020) Arnold J. Levine   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p53, cancer and the immune response

(2020) Julianna Blagih et al.   JOURNAL OF CELL SCIENCE

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

(2020) Kumar Sachin Singh et al.   Nature Communications

A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

(2020) Ju-Gyeong Kang et al.   Cell Reports

Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells

(2020) Marco Cordani et al.   Biomolecules

Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy

(2020) Wang Zheng et al.   MOLECULAR CARCINOGENESIS

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

(2020) Longfei Deng et al.   Nature Communications

TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

(2020) Jie Cheng et al.   Nature Communications

Liver osteopontin is required to prevent the progression of age‐related nonalcoholic fatty liver disease

(2020) Beatriz Gómez‐Santos et al.   AGING CELL

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

(2020) Tobiloba E. Oni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting p53 for the treatment of cancer

(2020) Michael J. Duffy et al.   SEMINARS IN CANCER BIOLOGY

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology

(2020) Bruno Saleme et al.   Journal of the American Heart Association

PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer

(2020) Wei Xia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Non-coding RNAs, guardians of the p53 galaxy

(2020) Song Chen et al.   SEMINARS IN CANCER BIOLOGY

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression

(2020) Ning Kon et al.   GENES & DEVELOPMENT

p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer

(2019) Hyo Won Chang et al.   ONCOGENE

Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells

(2019) Heena Saini et al.   Journal of Oncology

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

(2019) Xazmin H. Lowman et al.   Cell Reports

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis

(2019) Le Li et al.   NATURE

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

(2019) Jinchul Kim et al.   CANCER CELL

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

(2019) Yufei Wang et al.   EMBO REPORTS

Impact of p53 function on the sulfotransferase‐mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1‐hydroxymethylpyrene in vitro

(2019) Laura E. Wohak et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

(2019) Julia I-Ju Leu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis

(2019) Yanhong Zhang et al.   ONCOGENE

Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms

(2019) Jiajun Huang et al.   EBioMedicine

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism

(2019) Stephen L. Clarke et al.   Nutrients

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

(2019) Matthieu Lacroix et al.   Molecular Metabolism

Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance

(2019) Nan Liu et al.   BRITISH JOURNAL OF CANCER

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases

(2019) Thineskrishna Anbarasan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis

(2019) Yan Stein et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Control of metabolism by p53 – Cancer and beyond

(2018) Christiaan F. Labuschagne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Regulators of the Transsulfuration Pathway

(2018) Juan I Sbodio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

p53: emerging roles in stem cells, development and beyond

(2018) Abhinav K. Jain et al.   DEVELOPMENT

CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions

(2018) Meenu Maan et al.   FEBS Journal

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α

(2018) Subhasree Basu et al.   GENES & DEVELOPMENT

Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells

(2018) Jacek Stepniewski et al.   IUBMB LIFE

IGF1 receptor signaling pathways

(2018) Fumihiko Hakuno et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Multiple Faces of the Metal Transporter ZIP14 (SLC39A14)

(2018) Tolunay B Aydemir et al.   JOURNAL OF NUTRITION

p53 and glucose metabolism: an orchestra to be directed in cancer therapy

(2018) Ana Sara Gomes et al.   PHARMACOLOGICAL RESEARCH

ALIMA1variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

(2018) Ying-Yu Zhang et al.   SCIENCE

PML nuclear bodies, membrane-less domains acting as ROS sensors?

(2018) Michiko Niwa-Kawakita et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

p53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression

(2018) Jiahong Sun et al.   Cell Death & Disease

Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects

(2018) Ning Kon et al.   Oncotarget

Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

(2018) Kamil Lisek et al.   Oncotarget

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway

(2018) Yun Zhou et al.   Cancer Medicine

Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression

(2018) Ikuno Uehara et al.   Cancers

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy

(2018) Sebastian Brachtendorf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PHLDA1, another PHLDA family protein that inhibits Akt

(2018) Yu Chen et al.   CANCER SCIENCE

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

(2018) Mylène Tajan et al.   Cell Metabolism

p53 tumor suppressor and iron homeostasis

(2018) Jin Zhang et al.   FEBS Journal

Mutant p53R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells

(2018) Ileana Hernández-Reséndiz et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells

(2018) Hidekazu Nagano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis

(2018) Meiting Li et al.   Cell Death & Disease

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

(2018) Marco Cordani et al.   BRITISH JOURNAL OF CANCER

A GYS2/p53 negative feedback loop restricts tumor growth in HBV-related hepatocellular carcinoma

(2018) Shi-Lu Chen et al.   CANCER RESEARCH

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

(2018) Giuseppe Lonetto et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas

(2018) Yuan Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance

(2018) Jixiang Zhang et al.   ONCOGENE

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2

(2017) Yanhong Zhang et al.   GENES & DEVELOPMENT

PML is a ROS sensor activating p53 upon oxidative stress

(2017) Michiko Niwa-Kawakita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury

(2017) Kojiro Nakamura et al.   JOURNAL OF HEPATOLOGY

Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism

(2017) Matilda Eriksson et al.   MOLECULAR AND CELLULAR BIOLOGY

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport

(2017) Arvindhan Nagarajan et al.   MOLECULAR CELL

Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis

(2017) Eleonora Ingallina et al.   NATURE CELL BIOLOGY

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells

(2017) S Ros et al.   ONCOGENE

Genomic alterations during p53-dependent apoptosis induced by γ-irradiation of Molt-4 leukemia cells

(2017) Rouba Hage-Sleiman et al.   PLoS One

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

(2017) Juan Liu et al.   Nature Communications

The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14

(2017) Ningning Zhao et al.   Nutrients

P53 suppresses ribonucleotide reductase via inhibiting mTORC1

(2017) Zhengfu He et al.   Oncotarget

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53

(2017) Takafumi Miyamoto et al.   Science Advances

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

(2016) Marco Napoli et al.   BRITISH JOURNAL OF CANCER

Lack of p53 Augments Antitumor Functions in Cytolytic T Cells

(2016) Anirban Banerjee et al.   CANCER RESEARCH

p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

(2016) Alice D. Baudot et al.   CELL CYCLE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Mutant p53 and mTOR/PKM2 regulation in cancer cells

(2016) Ilaria Dando et al.   IUBMB LIFE

Parkin Regulates the Activity of Pyruvate Kinase M2

(2016) Kun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CerS6Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

(2016) Baharan Fekry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53

(2016) Romain Riscal et al.   MOLECULAR CELL

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

(2016) Alejandro Parrales et al.   NATURE CELL BIOLOGY

Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction

(2016) T Q Tran et al.   ONCOGENE

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer

(2016) Shilei Wen et al.   Oncotarget

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

(2016) Che-Pei Kung et al.   Cell Reports

Regulation of Cellular Metabolism and Hypoxia by p53

(2016) Timothy J. Humpton et al.   Cold Spring Harbor Perspectives in Medicine

Long noncoding RNAs in the p53 network

(2016) Ritu Chaudhary et al.   Wiley Interdisciplinary Reviews-RNA

Regulation of cytotoxic T-cell responses by p53 in cancer

(2016) Mitchell W. Braun et al.   Translational Cancer Research

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway

(2016) Derek A. Franklin et al.   Scientific Reports

Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle

(2015) Ayesha Saleem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice

(2015) Annette M. Krais et al.   ARCHIVES OF TOXICOLOGY

PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane

(2015) Stephan Gehrke et al.   Cell Metabolism

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies inTrp53(+/+),Trp53(+/−) andTrp53(−/−) mice

(2015) Annette M. Krais et al.   INTERNATIONAL JOURNAL OF CANCER

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumour suppressor protein p53 regulates the stress activated bilirubin oxidase cytochrome P450 2A6

(2015) Hao Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

p53 regulates the mevalonate pathway in human glioblastoma multiforme

(2015) C Laezza et al.   Cell Death & Disease

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

(2015) A A Shamseddine et al.   Cell Death & Disease

The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development

(2015) J. L. Van Nostrand et al.   Cancer Discovery

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy

(2015) Nastasia Wilfinger et al.   Oncotarget

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

(2015) Min-Che Tung et al.   Oncotarget

p53 attenuates AKT signaling by modulating membrane phospholipid composition

(2015) Natalia Rueda-Rincon et al.   Oncotarget

Regulation of iron homeostasis by the p53-ISCU pathway

(2015) Yuki Funauchi et al.   Scientific Reports

Analysis of p53 Transactivation Domain Mutants Reveals Acad11 as a Metabolic Target Important for p53 Pro-Survival Function

(2015) Dadi Jiang et al.   Cell Reports

NRF2 and p53: Januses in cancer?

(2015) Barak Rotblat et al.   Oncotarget

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

(2015) Cen Zhang et al.   Oncotarget

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

(2015) Vamsi K. Kolukula et al.   Oncotarget

Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells

(2014) H E Boudreau et al.   BRITISH JOURNAL OF CANCER

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron

(2014) Rina Shimizu et al.   GENE

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

(2014) Yang Ou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers

(2014) Bao Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State

(2014) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

(2014) B. Ashok Reddy et al.   MOLECULAR CELL

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

(2014) Y Itahana et al.   ONCOGENE

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53

(2014) S. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

(2014) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity

(2014) Masataka Yokoyama et al.   Cell Reports

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

(2014) Jia Shen et al.   Cell Reports

TRP53 activates a global autophagy program to promote tumor suppression

(2013) Daniela Kenzelmann Broz et al.   Autophagy

p53 regulates glucose metabolism by miR-34a

(2013) Hwa-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F₀-ATP synthase

(2013) Marie Bergeaud et al.   CELL CYCLE

p53-dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

(2013) Shang-Jui Wang et al.   CELL CYCLE

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

(2013) A Molchadsky et al.   CELL DEATH AND DIFFERENTIATION

TXNIP Maintains the Hematopoietic Cell Pool by Switching the Function of p53 under Oxidative Stress

(2013) Haiyoung Jung et al.   Cell Metabolism

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

(2013) Ippei Shimizu et al.   Cell Metabolism

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118acetylation

(2013) Rajan Gogna et al.   EMBO Molecular Medicine

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

(2013) Rossella Pellegrino et al.   HEPATOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Activation of p53 by spermine mediates induction of autophagy in HT1080 cells

(2013) Yong-Byung Chae et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells

(2013) Hao He et al.   JOURNAL OF ETHNOPHARMACOLOGY

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

(2013) G. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular Adenosine Sensing—A Metabolic Cell Death Priming Mechanism Downstream of p53

(2013) Jaclyn S. Long et al.   MOLECULAR CELL

The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

(2013) Michael A. Reid et al.   MOLECULAR CELL

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

The Emerging Role of p53 in Exercise Metabolism

(2013) Jonathan D. Bartlett et al.   SPORTS MEDICINE

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH

(2012) Hwa-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

(2012) C.-W. Lee et al.   CANCER RESEARCH

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Identification of NCF2/p67phox as a novel p53 target gene

(2012) Dafne Italiano et al.   CELL CYCLE

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation

(2012) P Hallenborg et al.   CELL DEATH AND DIFFERENTIATION

The critical role of catalase in prooxidant and antioxidant function of p53

(2012) M Y Kang et al.   CELL DEATH AND DIFFERENTIATION

TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death

(2012) M Seillier et al.   CELL DEATH AND DIFFERENTIATION

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

(2012) M. Tatti et al.   HUMAN MOLECULAR GENETICS

Mutant p53R273Hattenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

(2012) Eyal Kalo et al.   JOURNAL OF CELL SCIENCE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

The p53-Dependent Expression of Frataxin Controls 5-Aminolevulinic Acid-Induced Accumulation of Protoporphyrin IX and Photo-Damage in Cancerous Cells

(2012) Mari Sawamoto et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

(2012) I. H. Lee et al.   SCIENCE

A new role of p53 in regulating lipid metabolism

(2012) Xingwu Wang et al.   Journal of Molecular Cell Biology

Redox Control and Interplay Between p53 Isoforms: Roles in the Regulation of Basal p53 Levels, Cell Fate, and Senescence

(2011) Hind Hafsi et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2

(2011) Aram You et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolic utilization of exogenous pyruvate by mutant p53 (R175H) human melanoma cells promotes survival under glucose depletion

(2011) Valery A. Chavez-Perez et al.   CANCER BIOLOGY & THERAPY

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF- B

(2011) R. F. Johnson et al.   CANCER RESEARCH

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions

(2011) Elizabeth M. Matthew et al.   CELL CYCLE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells

(2011) B. Schisano et al.   DIABETOLOGIA

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death

(2011) Xi Feng et al.   EMBO JOURNAL

Silencing of frataxin gene expression triggers p53-dependent apoptosis in human neuron-like cells

(2011) G. M. Palomo et al.   HUMAN MOLECULAR GENETICS

Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53

(2011) Joanna Zawacka-Pankau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation

(2011) Chad Deisenroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

Hypergrowth mTORC1 Signals Translationally Activate the ARF Tumor Suppressor Checkpoint

(2011) A. P. Miceli et al.   MOLECULAR AND CELLULAR BIOLOGY

Feedback Control of p53 Translation by REDD1 and mTORC1 Limits the p53-Dependent DNA Damage Response

(2011) D. D. Vadysirisack et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

(2011) Céline Charvet et al.   MOLECULAR CELL

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Defining a role for sphingosine kinase 1 in p53-dependent tumors

(2011) L A Heffernan-Stroud et al.   ONCOGENE

Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria

(2011) Noriaki Kitamura et al.   PLoS One

Tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner

(2011) D.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin-2 is a novel direct target of p53

(2010) Weilin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mdm2 and p53 are highly conserved from placozoans to man

(2010) David P. Lane et al.   CELL CYCLE

apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53

(2010) Osnat Ashur-Fabian et al.   CELL CYCLE

p53-dependent repression of polo-like kinase-1 (PLK1)

(2010) Lynsey McKenzie et al.   CELL CYCLE

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

(2010) Keng Po Lai et al.   EMBO JOURNAL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway

(2010) A. A. Khutornenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redox Control of the Cell Cycle in Health and Disease

(2009) Ehab H. Sarsour et al.   ANTIOXIDANTS & REDOX SIGNALING

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

(2009) Tatsuya Kawase et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Suppression of p53 activity by Siva1

(2009) W Du et al.   CELL DEATH AND DIFFERENTIATION

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Iron Chelator-Mediated Alterations in Gene Expression: Identification of Novel Iron-Regulated Molecules That Are Molecular Targets of Hypoxia-Inducible Factor-1  and p53

(2009) F. Saletta et al.   MOLECULAR PHARMACOLOGY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

(2009) H.-C. Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 represses c-Myc through induction of the tumor suppressor miR-145

(2009) M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis

(2008) Jianfei Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

(2008) C. E. Cano et al.   CANCER RESEARCH

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

(2008) J. C. O'Connor et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest

(2008) Fan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

(2008) T. S. Wong et al.   NUCLEIC ACIDS RESEARCH

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

(2008) Peter M. Wilson et al.   NUCLEIC ACIDS RESEARCH

TP53 Status and Response to Chemotherapy in Breast Cancer

(2008) Philippe Bertheau et al.   PATHOBIOLOGY

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

(2008) Yen-Chun Liu et al.   PLoS One