Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions

(2015) Jason M. Hinzman et al.   EXPERIMENTAL NEUROLOGY

Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes

(2015) Jakob D. Nissen et al.   GLIA

Glucose replaces glutamate as energy substrate to fuel glutamate uptake in glutamate dehydrogenase-deficient astrocytes

(2015) Kamilla Pajęcka et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Tribute to Mary C. McKenna: Glutamate as Energy Substrate and Neurotransmitter—Functional Interaction Between Neurons and Astrocytes

(2015) Arne Schousboe   NEUROCHEMICAL RESEARCH

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

(2015) Karthik Raju et al.   Science Signaling

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

(2015) Melis Karaca et al.   Cell Reports

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

(2015) Karthik Raju et al.   Science Signaling

Glutamate synthesis has to be matched by its degradation - where do all the carbons go?

(2014) Ursula Sonnewald   JOURNAL OF NEUROCHEMISTRY

Neuronal Activity and Glutamate Uptake Decrease Mitochondrial Mobility in Astrocytes and Position Mitochondria Near Glutamate Transporters

(2014) J. G. Jackson et al.   JOURNAL OF NEUROSCIENCE

Advances in Astrocyte-targeted Approaches for Stroke Therapy: An Emerging Role for Mitochondria and microRNAS

(2014) Creed M. Stary et al.   NEUROCHEMICAL RESEARCH

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

P2Y1R-Initiated, IP3R-Dependent Stimulation of Astrocyte Mitochondrial Metabolism Reduces and Partially Reverses Ischemic Neuronal Damage in Mouse

(2013) Wei Zheng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MS-275, a Class I histone deacetylase inhibitor, protects the p53-deficient mouse against ischemic injury

(2013) Sean P. Murphy et al.   JOURNAL OF NEUROCHEMISTRY

Novel Protective Effects of Histone Deacetylase Inhibition on Stroke and White Matter Ischemic Injury

(2013) Selva Baltan et al.   Neurotherapeutics

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Inhibitors of Glutamate Dehydrogenase Block Sodium-Dependent Glutamate Uptake in Rat Brain Membranes

(2013) Brendan S. Whitelaw et al.   Frontiers in Endocrinology

Glutamate Pays Its Own Way in Astrocytes

(2013) Mary C. McKenna   Frontiers in Endocrinology

Histone deacetylase inhibitors preserve function in aging axons

(2012) Selva Baltan   JOURNAL OF NEUROCHEMISTRY

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

(2012) Francesca Frigerio et al.   JOURNAL OF NEUROCHEMISTRY

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

(2012) Dorte M. Skytt et al.   NEUROCHEMISTRY INTERNATIONAL

The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism

(2012) Deborah E. Bauer et al.   NEUROCHEMISTRY INTERNATIONAL

GluN3 subunit-containing NMDA receptors: not just one-trick ponies

(2012) Svenja Pachernegg et al.   TRENDS IN NEUROSCIENCES

Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex

(2012) Andreas Reiner et al.   Cell Reports

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histone Deacetylase Inhibitors Preserve White Matter Structure and Function during Ischemia by Conserving ATP and Reducing Excitotoxicity

(2011) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria

(2011) E. N. Genda et al.   JOURNAL OF NEUROSCIENCE

Neuron-glia interactions in glutamatergic neurotransmission: Roles of oxidative and glycolytic adenosine triphosphate as energy source

(2011) A. Schousboe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Calcium signalling in astroglia

(2011) Alexei Verkhratsky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

P2X Receptors and Their Roles in Astroglia in the Central and Peripheral Nervous System

(2011) Peter Illes et al.   NEUROSCIENTIST

Dibucaine Mitigates Spreading Depolarization in Human Neocortical Slices and Prevents Acute Dendritic Injury in the Ischemic Rodent Neocortex

(2011) W. Christopher Risher et al.   PLoS One

ATP: A ubiquitous gliotransmitter integrating neuron–glial networks

(2011) Arthur M. Butt   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia

(2011) Selva Baltan et al.   Translational Stroke Research

Ionotropic receptors in neuronal–astroglial signalling: What is the role of “excitable” molecules in non-excitable cells

(2010) Ulyana Lalo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes

(2010) Oleg Palygin et al.   CELL CALCIUM

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes

(2010) Valeria Burzomato et al.   JOURNAL OF PHYSIOLOGY-LONDON

The effects of parent body processes on amino acids in carbonaceous chondrites

(2010) Daniel P. GLAVIN et al.   METEORITICS & PLANETARY SCIENCE

Purinergic Receptor Stimulation Reduces Cytotoxic Edema and Brain Infarcts in Mouse Induced by Photothrombosis by Energizing Glial Mitochondria

(2010) Wei Zheng et al.   PLoS One

Evolutionary Mode and Functional Divergence of Vertebrate NMDA Receptor Subunit 2 Genes

(2010) Huajing Teng et al.   PLoS One

Gliotransmission: Exocytotic release from astrocytes

(2009) Vladimir Parpura et al.   BRAIN RESEARCH REVIEWS

Glutamate Transporter Coupling to Na,K-ATPase

(2009) E. M. Rose et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes

(2008) Nicola Hamilton et al.   GLIA

P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes

(2008) U. Lalo et al.   JOURNAL OF NEUROSCIENCE

White Matter Vulnerability to Ischemic Injury Increases with Age Because of Enhanced Excitotoxicity

(2008) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

Mitochondria: The Hub of Cellular Ca2+ Signaling

(2008) György Szabadkai et al.   PHYSIOLOGY

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES

Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury

(2007) Ferah Yildirim et al.   EXPERIMENTAL NEUROLOGY