Article
Agriculture, Multidisciplinary
Hong Sun, Juan Chen, Lili Sun, Bimin Shi, Jianzhong Li
Summary: Research found that silencing TXNIP can reduce renal lipid deposition, inhibit cholesterol uptake and synthesis through regulating SCAP, and may be a potential therapeutic target for treating a diabetic fatty kidney.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Oncology
Weiwei Ge, Jian Jie, Jie Yao, Wei Li, Yahui Cheng, Wenjuan Lu
Summary: This study investigated the effect of AGEs on osteoblast function and the underlying mechanisms. The results showed that AGEs disrupted osteoblast function by inducing cell ferroptosis, contributing to osteoporosis (OP). AGEs and serum from OP patients inhibited cell proliferation, differentiation, and mineralization, while promoting apoptosis and ferroptosis. Serum from OP patients with type-2 diabetes mellitus (T2DM) had a stronger effect than that from OP patients with normal fasting blood glucose (FBG). However, the ferroptosis inhibitor, deferoxamine (DFO), reversed the effects induced by AGEs and serum from OP and T2DM patients on osteoblast cells.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Chemistry, Physical
Vaishali Rana, Ahana Mukherjee, Yogita Basnal, Deepak Kushwaha, Jaydeep Bhattacharya, Ranjita Ghosh Moulick
Summary: The elevated blood sugar in Type II diabetes leads to the formation of Advanced Glycation Endproducts (AGEs), which cause severe pathogenic complications. Previous research has shown that AGEs generated from Hemoglobin A0 (HbA0) can synthesize gold nanoparticles (AuNPs). In this study, it was found that these AGEs can also reduce silver ions and synthesize silver nanoparticles (AgNPs) with a different plasmonic response. The research demonstrates that AGEs can be detected by deploying metal salts in solution.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Nanoscience & Nanotechnology
Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O. Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg
Summary: A simple method for colorimetric and fluorometric profiling of AGEs was reported in this study, utilizing changes in optical properties of PTs and Apts to estimate the concentrations of AGEs in plasma, and achieving distinct profiling of different AGEs through PCA analysis. The approach allows for rapid analysis of spiked AGEs in plasma samples without the need for preanalytical processing and advanced instrumentation, facilitating on-site diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Cong-Jin Liu, Xiao Yang, Shou-Hui Wang, Xin-Tong Wu, Yan Mao, Jing-Wen Shi, Yu-Bo Fan, Lian-Wen Sun
Summary: Bone loss occurs in astronauts during long-term space flight, and this study investigated the improvement effects of blocking AGEs formation on microgravity-induced bone loss using the AGES formation inhibitor, irbesartan. Results showed that irbesartan significantly inhibited AGEs and 8-OHdG expression, improving bone quality and bone formation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Review
Nutrition & Dietetics
Kate Phuong-Nguyen, Bryony A. A. McNeill, Kathryn Aston-Mourney, Leni R. R. Rivera
Summary: Consuming a high-AGE diet can lead to changes in gastrointestinal structure, modifications in enteric neurons, and reshaping of the microbiota, resulting in poor health outcomes.
Article
Medicine, Research & Experimental
Jawhar Hafsa, Khaoula Mkadmini Hammi, Med Raafet Ben Khedher, Med Ali Smach, Bassem Charfeddine, Khalifa Limem, Hatem Majdoub
BIOMEDICINE & PHARMACOTHERAPY
(2016)
Article
Food Science & Technology
Jawhar Hafsa, Med ali Smach, Med Raafet Ben Khedher, Bassem Charfeddine, Khalifa Limem, Hatem Majdoub, Sonia Rouatbi
LWT-FOOD SCIENCE AND TECHNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Mohamed Raafet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed, Mohamed Abid, Kamel Jamoussi, Mohamed Hammami
LIPIDS IN HEALTH AND DISEASE
(2017)
Article
Multidisciplinary Sciences
Mohamed R. Ben Khedher, Mohamed Hammami, Jonathan R. S. Arch, David C. Hislop, Dominic Eze, Edward T. Wargent, Magorzata A. Kepczynska, Mohamed S. Zaibi
Article
Andrology
M. R. Ben Khedher, M. Abid, K. Jamoussi, M. Hammami
Article
Biochemistry & Molecular Biology
Mohamed Haddad, Morgane Perrotte, Mohamed Raafet Ben Khedher, Clement Demongin, Aurelie Lepage, Tamas Fulop, Charles Ramassamy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Plant Sciences
Mohamed Raafet Ben Khedher, Jawhar Hafsa, Mohamed Haddad, Mohamed Hammami
PLANT FOODS FOR HUMAN NUTRITION
(2020)
Article
Neurosciences
Mohamed Haddad, Morgane Perrotte, Mohamed Raafet Ben Khedher, Elise Madec, Aurelie Lepage, Tamas Fulop, Charles Ramassamy
Summary: The study found that levels of RAGE and GLO-1 in circulating EVs were correlated with cognitive function in AD patients, and demonstrated for the first time that GLO-1 can be released by neuronal cells through EVs. These findings support the use of peripheral EVs as a new tool for discovering AD biomarkers.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Mohamed Raafet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy
Summary: This study found that levels of neurotrophic and inflammatory markers are reduced in pEVs from APOE ε4(+) individuals, and the pentraxin-2/alpha-synuclein ratio in pEVs could serve as an early biomarker for AD susceptibility in APOE ε4(+)-CIND individuals. These findings suggest an alteration in the endosomal pathway in APOE ε4(+) individuals.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2021)
Article
Clinical Neurology
Mohamed Raafet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy
Summary: The study examined the impact of APOE epsilon 4 on antioxidant apolipoproteins in circulating extracellular vesicles and plasma from individuals with cognitive impairment. Results showed that total antioxidant capacity and apolipoprotein D levels in cEVs could differentiate APOE epsilon 4 carriers from controls and predict their progression to AD after 5 years. These findings support the link between APOE epsilon 4 and AD onset, suggesting the potential use of cEVs oxidative signature in early AD diagnosis.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2021)
Article
Biology
Med Raafet Ben Khedher, Saoussen Ben Khedher, Ikbal Chaieb, Slim Tounsi, Mohamed Hammami