Review
Chemistry, Multidisciplinary
Nayeon Kang, Subin Son, Sunhong Min, Hyunsik Hong, Chowon Kim, Jusung An, Jong Seung Kim, Heemin Kang
Summary: Ferroptosis, an iron-dependent programmed cell death mechanism, can be regulated by intracellular iron supplementation and glutathione synthesis inhibition. Utilizing various endogenous and exogenous stimuli, such as tumor microenvironment conditions and external energy sources, can provide precise control and controllability for ferroptosis-based cancer therapy. The utilization of dual stimuli provides a new direction for efficient cancer therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Danqing Qin, Dong Li, Chunjuan Wang, Shougang Guo
Summary: Ferroptosis, a newly discovered form of programmed cell death, is caused by intracellular iron excess and glutathione (GSH) system imbalance, resulting in fatal lipid peroxidation. It differs from other forms of cell death such as necrosis, apoptosis, and autophagy. Accumulating evidence suggests that brain iron overload is involved in the development of demyelinating diseases of the central nervous system (CNS) like multiple sclerosis (MS), neuromyelitis optica (NMO), and acute disseminated encephalomyelitis (ADEM). Understanding ferroptosis may offer a new perspective on demyelinating diseases and potentially lead to novel therapeutic targets.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Cell Biology
Jiamin Li, Yunxiang Zhou, Hui Wang, Jianyao Lou, Cameron Lenahan, Shiqi Gao, Xiaoyu Wang, Yongchuan Deng, Han Chen, Anwen Shao
Summary: Ferroptosis, a new type of iron-regulated cell death induced by oxidative stress, plays a crucial role in cardiovascular diseases. Epigenetic regulators are emerging as a promising option for modifying the signaling pathway of ferroptosis and oxidative stress to treat CVDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohammad Reza Sepand, Armin Salek Maghsoudi, Amir Shadboorestan, Kayvan Mirnia, Mehdi Aghsami, Mohammad Raoufi
Summary: Although numerous studies have been conducted on the mechanisms of cigarette smoking toxicity in the past three decades, there are still some aspects that remain unclear. Recent developments have raised hopeful indicators that enhance our understanding of cigarette-induced cell death, proposing suggestions for detoxification and therapeutic interventions.
Review
Cell Biology
Anna Maria Fratta Pasini, Chiara Stranieri, Fabiana Busti, Edoardo Giuseppe Di Leo, Domenico Girelli, Luciano Cominacini
Summary: Cardiovascular diseases (CVDs) are the leading cause of disease burden and death globally. Ferroptosis, characterized by altered iron metabolism and increased lipid peroxidation, has been found to play a key role in the pathogenesis of CVDs such as ischemic heart disease and cardiomyopathies. This article reviews the molecular mechanism of ferroptosis and its involvement in ischemic heart disease and cardiomyopathies, and suggests that understanding the regulation of ferroptosis in vascular and cardiac cells may lead to new strategies for preventing and treating CVDs.
Review
Clinical Neurology
Samuel David, Fari Ryan, Priya Jhelum, Antje Kroner
Summary: Iron accumulation in the CNS is common in neurological disorders and can contribute to neuropathology through the generation of free radicals. Ferroptosis, a form of cell death induced by iron, has been shown to occur under conditions of deficient antioxidant defense. Iron chelation has limited success in treating neurological diseases, leading to increased interest in ferroptosis as a potential therapeutic target.
Review
Chemistry, Inorganic & Nuclear
Mohammad Reza Sepand, Banafsheh Bigdelou, Armin Salek Maghsoudi, Nima Sanadgol, Jim Q. Ho, Prashant Chauhan, Mohammad Raoufi, Atefeh Kermanian, Rahim Esfandyarpour, Mohammad Javad Hajipour, Steven Zanganeh
Summary: Ferroptosis is an iron-mediated cell death that combines cell metabolism, redox status, and human disease. Excessive reactive oxygen species (ROS) can lead to cellular oxidative changes, suppress protein activity, and trigger cell death. This review summarizes the effects of environmental chemical exposure on cellular redox signaling, ferroptosis, and cell death, providing critical information to mitigate the impact of ferroptosis on human health.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Jinliang Gao, Tao Luo, Jinke Wang
Summary: A therapy based on gene interference-enhanced ferroptosis was developed, utilizing iron nanoparticles to induce significant cell death in cancer cells while having little effect on normal cells. The combination of iron nanoparticles and gene interference led to tumor growth inhibition and durable cure in mice, showing promising results for potential cancer treatment strategies.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Ming Yang, Kwok-Fai So, Wai-Ching Lam, Amy Cheuk Yin Lo
Summary: Retinitis pigmentosa (RP) is a genetic retinal degenerative disease with more than 60 gene mutations. Recent studies have suggested a potential involvement of ferroptosis, a novel form of programmed cell death characterized by iron overload and lipid peroxidation, in the pathogenesis of RP. This finding may open up new avenues for research and novel therapeutic targets for RP.
Article
Cell Biology
Chengxian Xu, Shaogang Sun, Travis Johnson, Rong Qi, Siyuan Zhang, Jie Zhang, Kai Yang
Summary: Research shows that Gpx4 plays a crucial role in protecting Treg cells from lipid peroxidation and ferroptosis, regulating immune homeostasis and antitumor immunity. Deletion of Gpx4 can lead to lipid peroxidation and ferroptosis of Treg cells, affecting immune homeostasis and antitumor immunity. Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.
Article
Biochemistry & Molecular Biology
Jing Li, Junhua Li, Yuji Pu, Sai Li, Wenxia Gao, Bin He
Summary: This study introduced a novel nanocomplex PAF for enhanced cancer treatment through photodynamic therapy, demonstrating potent anticancer effects. The PAF showed excellent biocompatibility and enhanced photodynamic and near-infrared absorption capabilities under acidic conditions. The findings suggest that PDT-enhanced ferroptosis in PAF could be a promising strategy for nanotherapeutics due to its high potency, tumor selectivity, and excellent biocompatibility.
Article
Multidisciplinary Sciences
Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang
Summary: Ferroptosis is a type of iron-dependent regulated cell death, and the stress-inducible transcription factor NUPR1 may drive resistance to ferroptosis by mediating LCN2 expression. Blocking the NUPR1-LCN2 pathway can increase ferroptosis inducer activity and worsen conditions like pancreatitis in relevant mouse models.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Zhaojin Zeng, Haohua Huang, Jinming Zhang, Yuanyuan Liu, Wenshan Zhong, Weimou Chen, Ye Lu, Yujie Qiao, Haijin Zhao, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Dong
Summary: This study found that ferroptosis plays an important role in house dust mite-induced asthma models, and ferroptosis inhibitors can reduce airway inflammation. This research reveals that ferroptosis may be a potential treatment target for house dust mite-induced asthma.
Review
Cell Biology
Bumin Xie, Yuan Guo
Summary: Ferroptosis is a newly identified form of regulated cell death characterized by iron-dependent accumulation of lipid reactive oxygen species, closely related to various diseases and tumor treatment. Noncoding RNAs play a crucial role in regulating the molecular mechanism of ferroptosis in tumor cells.
CELL DEATH DISCOVERY
(2021)
Review
Immunology
Yili Zhang, Xinyi Huang, Baoyu Qi, Chuanrui Sun, Kai Sun, Ning Liu, Liguo Zhu, Xu Wei
Summary: Ferroptosis plays a crucial role in musculoskeletal disorders and has potential as a treatment strategy. However, more research is needed to understand its toxicity to other organs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Zhiqiang Du, Ying Jiang, Yuan Shen, Qin Zhou, Shushan Wang, Haohao Zhu, Yingying Ji
Summary: This study analyzed the occurrence characteristics and related influencing factors of adverse reactions of psychiatric drugs under the Chinese drug volume-based procurement policy (4+7 policy). It was found that these adverse reactions mainly involved the digestive system, nervous system, cardiovascular system, and blood and lymphatic system, with the digestive system being the most common. Most adverse reactions improved or were cured after discontinuation or dose reduction, with no deaths, disabilities, or teratogenicity.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Medicine, General & Internal
S. M. Li, B. B. Guo, Q. P. Yang, J. Y. Yin, L. Tian, Y. Y. Ji, Y. Jiang, H. H. Zhu
Summary: This study explored the mental health status and influencing factors among community residents in Jiangsu Province, China, during the post-epidemic era of COVID-19. The survey found a relatively high incidence of depressive and anxiety symptoms. Factors such as gender, education level, and residency type were identified as risk factors for depressive symptoms, while gender and residency type were risk factors for anxiety symptoms. The findings highlight the importance of addressing mental health issues among community residents in the post-epidemic era of COVID-19.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Review
Neurosciences
Yingying Ji, Kai Zheng, Shiming Li, Caili Ren, Ying Shen, Lin Tian, Haohao Zhu, Zhenhe Zhou, Ying Jiang
Summary: Ferroptosis, as a newly discovered form of cell death, plays a key role in the occurrence and development of neurodegenerative diseases. However, the underlying mechanism of ferroptosis in these diseases remains unclear, and further research is needed to explore its therapeutic potential.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Shiming Li, Bingbing Guo, Queping Yang, Jieyun Yin, Lin Tian, Haohao Zhu, Yingying Ji, Zhenhe Zhou, Ying Jiang
Summary: This study investigated the occurrence and influencing factors of post-stroke depression in first-episode stroke patients. The results showed that male gender, smoking, onset in autumn and winter, right side lesion, high BMI, high NIHSS score, and high systolic blood pressure variation were closely related to post-stroke depression.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Fuqiang Qian, Jian Liu, Hongyu Yang, Haohao Zhu, Zhiqiang Wang, Yue Wu, Zaohuo Cheng
Summary: This study investigates the association between plasma BDNF levels and Alzheimer's disease, as well as its influencing factors. The results show significant differences in BDNF levels among different patient groups and its correlation with cognitive impairment and clinical diagnosis. Age, education, occupation, and sample source also have an impact on BDNF levels.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Zhiqiang Du, Ying Jiang, Rongrong Lu, Yuan Shen, Mengmeng Ou, Zhe Wang, Lina Cao, Qin Zhou, Haohao Zhu
Summary: The study aims to establish a prescription medication abuse (PMA) monitoring model for psychiatric hospitals and assess its applicability. The established monitoring system resulted in a significant increase in the number of reported cases of PMA compared to the previous year. Most cases were identified through active real-time monitoring and involved adolescents. The combined monitoring model effectively improves the quality of PMA monitoring and provides a basis for higher-level regulatory authorities' supervision.
FRONTIERS IN PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Shiming Li, Queping Yang, Jieyun Yin, Ning Qian, Yingying Ji, Ying Jiang, Haohao Zhu
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Public, Environmental & Occupational Health
Shiming Li, Shui Yu, Queping Yang, Jieyun Yin, Haohao Zhu, Ying Jiang, Yingying Ji
Summary: This systematic review and meta-analysis found a relatively high prevalence of suicide ideation among HIV/AIDS patients in China, with an incidence rate of 30.6%. Subgroup analysis indicated that male patients, homosexual patients, surveys conducted from 2013-2021, unmarried patients, patients diagnosed for more than 1 year, patients with depression, and patients with CD4 cell counts below 200 cells/ul had higher rates of suicide ideation.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Ying Jiang, Rongrong Lu, Mengmeng Ou, Qin Zhou, Zhiqiang Du, Haohao Zhu
Summary: This study examined the utility of internet-based pharmacy services in psychiatric hospitals during the COVID-19 pandemic. The findings revealed a significant increase in demand for these services, with patients seeking consultations primarily related to adverse drug reactions, drug selection and administration, long-term medication adherence, and drug distribution.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Yingying Ji, Xiaolong Wang, Han Wu, Xuemei Ni, Caili Ren, Tong Wang, Haohao Zhu, Ying Jiang, Kai Zheng
Summary: This study analyzed a total of 350 first-time AIS elderly patients (aged >= 60 years) and found several risk factors for post-stroke cognitive impairment (PSCI), including lesion site, frontal temporal, cerebral white matter degeneration, age >= 75 years, BMI >= 28, onset in autumn/winter, hospitalization expenses > 20,000 yuan/month, high DBPV, high NIHSS score, and high HAMD score. Higher education level was found to be a protective factor. Therefore, more attention should be paid to these patients to prevent PSCI.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Yingying Ji, Xuemei Ni, Kai Zheng, Ying Jiang, Caili Ren, Haohao Zhu, Ming Xiao, Tong Wang
Summary: This research found that the combination of transcranial direct current stimulation (tDCS) and aerobic exercise (AE) effectively improved executive function in healthy adults. The improvements were associated with changes in key serum biomarkers.
BRAIN RESEARCH BULLETIN
(2023)
Article
Psychiatry
Qin Zhou, Zhiqiang Du, Kankan Qu, Yuan Shen, Ying Jiang, Haohao Zhu, Xiuhong Zhang
Summary: This study analyzed adverse events data related to Epidiolex and found that most real-world reactions align with those mentioned in the drug's leaflet. However, some potential new side effects emerged, highlighting the need for further research on drug safety.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Ying Jiang, Zhiqiang Du, Yuan Shen, Qin Zhou, Haohao Zhu
Summary: This study analyzed data from the FAERS database to evaluate the relationship between Esketamine and specific adverse events. The findings provided important insights for clinical practice and regulatory decisions. Not only were known adverse events confirmed, but new potential adverse events were also identified. The study emphasized the need for caution regarding potential adverse reactions and risks associated with Esketamine.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Rupeng Dai, Xueting Bao, Ying Zhang, Yan Huang, Haohao Zhu, Kundi Yang, Bo Wang, Hongmei Wen, Wei Li, Jian Liu
Summary: In this study, hot-spot residues of ERα were identified using pharmacophore modeling, molecular mechanics/generalized Born surface area (MM/GBSA), and amino-acid mutation. Hit fragments were virtually screened and linked to generate compounds, among which compound B1 showed potential for breast cancer treatment.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Pharmacology & Pharmacy
Y. Jiang, Z. -Q. DU, H. -H. Zhu, Q. Wang
Summary: This case presentation describes the involvement of a clinical pharmacist in the treatment process of an elderly patient with CAP. Through comprehensive assessment, the clinical pharmacist selected appropriate medications and made timely adjustments based on the patient's condition, resulting in a positive treatment outcome.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)
