Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

Neuroinflammation in Alzheimer's Disease: Are NSAIDs and Selective COX-2 Inhibitors the Next Line of Therapy?

(2017) Catherine H. Trepanier et al.   JOURNAL OF ALZHEIMERS DISEASE

Synthetic and Natural Inhibitors of Phospholipases A2: Their Importance for Understanding and Treatment of Neurological Disorders

(2015) Wei-Yi Ong et al.   ACS Chemical Neuroscience

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Cytosolic phospholipase A2protein as a novel therapeutic target for spinal cord injury

(2014) Nai-Kui Liu et al.   ANNALS OF NEUROLOGY

Dietary Sutherlandia and Elderberry Mitigate Cerebral Ischemia-Induced Neuronal Damage and Attenuate p47phox and Phospho-ERK1/2 Expression in Microglial Cells

(2014) Dennis Y. Chuang et al.   ASN Neuro

Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System

(2014) Grace Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells

(2014) Jinghua Jiang et al.   PLoS One

Neuroinflammation and Neurodegeneration in Adult Rat Brain from Binge Ethanol Exposure: Abrogation by Docosahexaenoic Acid

(2014) Nuzhath Tajuddin et al.   PLoS One

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy

(2013) Arunabh Bhattacharya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Inhibition of cytosolic phospholipase A2 alpha protects against focal ischemic brain damage in mice

(2012) Jian Zhang et al.   BRAIN RESEARCH

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

(2012) Liya Qin et al.   Journal of Neuroinflammation

Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression

(2012) Michael Maes   METABOLIC BRAIN DISEASE

Integrating Cytosolic Phospholipase A2 with Oxidative/Nitrosative Signaling Pathways in Neurons: A Novel Therapeutic Strategy for AD

(2012) Grace Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists

(2012) Rachel Ribeiro et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter

(2011) Adam C. Vana et al.   EXPERIMENTAL NEUROLOGY

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase

(2011) Victor Kenyon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia

(2011) Wenwen Sheng et al.   Journal of Neuroinflammation

Proinflammatory treatment of astrocytes with lipopolysaccharide results in augmented Ca2+ signaling through increased expression of VIA phospholipase A2 (iPLA2)

(2010) Mikhail Strokin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Amelioration of the Alzheimer's Disease Phenotype by Absence of 12/15-Lipoxygenase

(2010) Hengxuan Yang et al.   BIOLOGICAL PSYCHIATRY

Eoxins: A new inflammatory pathway in childhood asthma

(2010) Christine Sachs-Olsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory role of cytosolic phospholipase A2α in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1-42in microglia

(2009) I. Szaingurten-Solodkin et al.   GLIA

Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model

(2009) Nobuyuki Tai et al.   INFLAMMATION RESEARCH

Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury

(2009) Wenlong Huang et al.   JOURNAL OF NEUROTRAUMA

Disrupted Membrane Homeostasis and Accumulation of Ubiquitinated Proteins in a Mouse Model of Infantile Neuroaxonal Dystrophy Caused by PLA2G6 Mutations

(2008) Ibrahim Malik et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduction of cPLA2αoverexpression: An efficient anti-inflammatory therapy for collagen-induced arthritis

(2008) Lior Raichel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

cPLA2phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells

(2008) Zoran Pavicevic et al.   JOURNAL OF LIPID RESEARCH

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

(2008) S. Feltenmark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA