Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease
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Title
Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease
Authors
Keywords
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Journal
Frontiers in Neuroscience
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-01-29
DOI
10.3389/fnins.2019.01443
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Note: Only part of the references are listed.- Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
- (2019) Allison McIntosh et al. BRAIN PATHOLOGY
- Treating Alzheimer's disease by targeting iron
- (2019) Sara Nikseresht et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System
- (2019) Karina Joppe et al. Frontiers in Neuroscience
- 7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease
- (2019) Boyd Kenkhuis et al. NeuroImage-Clinical
- Brain Iron Accumulation in Atypical Parkinsonian Syndromes: in vivo MRI Evidences for Distinctive Patterns
- (2019) Jae-Hyeok Lee et al. Frontiers in Neurology
- NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration
- (2019) Maria Quiles del Rey et al. Frontiers in Neuroscience
- Iron in Neurodegeneration – Cause or Consequence?
- (2019) Alain Ndayisaba et al. Frontiers in Neuroscience
- Ferroptosis is a type of autophagy-dependent cell death
- (2019) Borong Zhou et al. SEMINARS IN CANCER BIOLOGY
- Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis
- (2019) Andrew Tsatsanis et al. NEUROCHEMICAL RESEARCH
- Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
- (2019) Scott Ayton et al. MOLECULAR PSYCHIATRY
- Ferroptosis, a new form of cell death: opportunities and challenges in cancer
- (2019) Yanhua Mou et al. Journal of Hematology & Oncology
- Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds
- (2019) Li Gong et al. CELL TRANSPLANTATION
- An attempt to elucidate the role of iron and zinc ions in development of Alzheimer’s and Parkinson’s diseases
- (2019) Karolina Wojtunik-Kulesza et al. BIOMEDICINE & PHARMACOTHERAPY
- Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
- (2019) Ishraq Alim et al. CELL
- Metal Ions in Alzheimer’s Disease: A Key Role or Not?
- (2019) Yan Liu et al. ACCOUNTS OF CHEMICAL RESEARCH
- Brain iron transport
- (2019) Zhong‐Ming Qian et al. BIOLOGICAL REVIEWS
- Hypobaric hypoxia regulates iron metabolism in rats
- (2019) Yaru Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Transferrin and H‐ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype
- (2019) Brian Chiou et al. JOURNAL OF NEUROCHEMISTRY
- Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
- (2019) Wenbin Wan et al. Frontiers in Neurology
- Iron in Health and Disease: An Update
- (2019) Ashutosh Lal INDIAN JOURNAL OF PEDIATRICS
- Iron and Atherosclerosis: The Link Revisited
- (2019) Suowen Xu TRENDS IN MOLECULAR MEDICINE
- DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
- (2019) Rosaria Ingrassia et al. Frontiers in Neuroscience
- The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment
- (2019) Nao Yan et al. Frontiers in Neuroscience
- New insights into the role of iron in inflammation and atherosclerosis
- (2019) Anne Cornelissen et al. EBioMedicine
- Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective
- (2019) Paul J. Derry et al. PROGRESS IN NEUROBIOLOGY
- ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation
- (2019) Eunhee Park et al. Cell Death & Disease
- Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death
- (2019) Yong Qi Leong et al. METABOLIC BRAIN DISEASE
- Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer’s Disease
- (2018) Lei Du et al. ACS Chemical Neuroscience
- Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation
- (2018) Anthony Drecourt et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases
- (2018) Gerwyn Morris et al. BEHAVIOURAL BRAIN RESEARCH
- Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis
- (2018) Brian Chiou et al. GLIA
- Metal Ion Effects on Aβ and Tau Aggregation
- (2018) Anne Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier
- (2018) Brian Chiou et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects
- (2018) James Everett et al. Nanoscale
- Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease
- (2018) Marjolein Bulk et al. NEUROBIOLOGY OF AGING
- Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age
- (2018) J.M.G. van Bergen et al. NEUROIMAGE
- Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology
- (2018) Romina María Uranga et al. Oxidative Medicine and Cellular Longevity
- Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
- (2018) Moataz Abdalkader et al. Frontiers in Neuroscience
- 13 reasons why the brain is susceptible to oxidative stress
- (2018) James Nathan Cobley et al. Redox Biology
- α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice
- (2018) Yan-Hui Zhang et al. Redox Biology
- Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?
- (2018) D.A. Stoyanovsky et al. FREE RADICAL BIOLOGY AND MEDICINE
- Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration
- (2018) Shashank Masaldan et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Development of the Concept of Ferroptosis
- (2018) Tal Hirschhorn et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases
- (2018) Mingzhu Tang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Differential regulation of estrogen in iron metabolism in astrocytes and neurons
- (2018) Manman Xu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice
- (2018) Abdel A. Belaidi et al. Neurotherapeutics
- Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration
- (2018) Shalini S. Rao et al. Frontiers in Molecular Neuroscience
- Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
- (2018) Jun-Lin Liu et al. Frontiers in Neuroscience
- Liver iron sensing and body iron homeostasis
- (2018) Chia-Yu Wang et al. BLOOD
- Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury
- (2018) Elizabeth M. Kenny et al. CRITICAL CARE MEDICINE
- Ferroptosis and Its Role in Diverse Brain Diseases
- (2018) Abigail Weiland et al. MOLECULAR NEUROBIOLOGY
- Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology
- (2018) Ibrahima Diouf et al. NEUROBIOLOGY OF DISEASE
- Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents
- (2017) Marie Jouanne et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer's disease
- (2017) C. A. Lane et al. EUROPEAN JOURNAL OF NEUROLOGY
- Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center
- (2017) Giorgio Cozza et al. FREE RADICAL BIOLOGY AND MEDICINE
- Overview of iron metabolism in health and disease
- (2017) Som Dev et al. Hemodialysis International
- Dietary Modulation of Oxidative Stress in Alzheimer’s Disease
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Iron and ferroptosis: A still ill-defined liaison
- (2017) Sebastian Doll et al. IUBMB LIFE
- Cortical Iron Reflects Severity of Alzheimer’s Disease
- (2017) Sara van Duijn et al. JOURNAL OF ALZHEIMERS DISEASE
- No Genetic Overlap Between Circulating Iron Levels and Alzheimer’s Disease
- (2017) Michelle K. Lupton et al. JOURNAL OF ALZHEIMERS DISEASE
- Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
- (2017) Janou A. Y. Roubroeks et al. JOURNAL OF NEUROCHEMISTRY
- Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study
- (2017) Scott Ayton et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
- (2017) Q-z Tuo et al. MOLECULAR PSYCHIATRY
- Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain
- (2017) Cheng-Wu Zhang et al. NEUROMOLECULAR MEDICINE
- Iron in neurodegenerative disorders: being in the wrong place at the wrong time?
- (2017) Sotirios Apostolakis et al. REVIEWS IN THE NEUROSCIENCES
- Ferroptosis Inhibition: Mechanisms and Opportunities
- (2017) Jose Pedro Friedmann Angeli et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Pathology of Neurodegenerative Diseases
- (2017) Brittany N. Dugger et al. Cold Spring Harbor Perspectives in Biology
- Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers
- (2017) Scott Ayton et al. JAMA Neurology
- Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
- (2017) Xin Wang et al. Frontiers in Molecular Neuroscience
- Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
- (2017) William Sealy Hambright et al. Redox Biology
- Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
- (2017) Sandro Altamura et al. JOURNAL OF ALZHEIMERS DISEASE
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Ferroptosis: process and function
- (2016) Y Xie et al. CELL DEATH AND DIFFERENTIATION
- Ferroptosis is an autophagic cell death process
- (2016) Minghui Gao et al. CELL RESEARCH
- Mechanisms of ferroptosis
- (2016) Jennifer Yinuo Cao et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells
- (2016) Allegra T. Aron et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
- (2016) Alexander R. Bogdan et al. TRENDS IN BIOCHEMICAL SCIENCES
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
- (2016) J. M. G. van Bergen et al. Scientific Reports
- Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease
- (2015) Pravat K. Mandal et al. BIOLOGICAL PSYCHIATRY
- Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease
- (2015) Orly Weinreb et al. BRITISH JOURNAL OF PHARMACOLOGY
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- (2015) Liuji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β
- (2015) Keith A. Vossel et al. JOURNAL OF CELL BIOLOGY
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Iron and Neurodegeneration: Is Ferritinophagy the Link?
- (2015) Giorgio Biasiotto et al. MOLECULAR NEUROBIOLOGY
- Tau in physiology and pathology
- (2015) Yipeng Wang et al. NATURE REVIEWS NEUROSCIENCE
- The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin
- (2015) Douglas G. Peters et al. NEUROBIOLOGY OF DISEASE
- Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation
- (2015) Juan G. Zarruk et al. NEUROBIOLOGY OF DISEASE
- The Blood–Brain Barrier
- (2015) Richard Daneman et al. Cold Spring Harbor Perspectives in Biology
- Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
- (2015) Scott Ayton et al. Nature Communications
- Iron Homeostasis in Peripheral Nervous System, Still a Black Box?
- (2014) Sonia Levi et al. ANTIOXIDANTS & REDOX SIGNALING
- Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy
- (2014) Ryan C. McCarthy et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A Novel Model for Brain Iron Uptake: Introducing the Concept of Regulation
- (2014) Ian A Simpson et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The role of iron in brain ageing and neurodegenerative disorders
- (2014) Roberta J Ward et al. LANCET NEUROLOGY
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
- (2014) Joseph D. Mancias et al. NATURE
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
- (2014) William E. Dowdle et al. NATURE CELL BIOLOGY
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Regulated necrosis: the expanding network of non-apoptotic cell death pathways
- (2014) Tom Vanden Berghe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease
- (2014) Javier Becerril-Ortega et al. NEUROBIOLOGY OF AGING
- TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord
- (2014) Antje Kroner et al. NEURON
- β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin
- (2014) Bruce X. Wong et al. PLoS One
- Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin
- (2013) Johann Guillemot et al. HEPATOLOGY
- Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease
- (2013) Elizabeth C. Theil INORGANIC CHEMISTRY
- Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
- (2013) Pamela Urrutia et al. JOURNAL OF NEUROCHEMISTRY
- The role of iron and reactive oxygen species in cell death
- (2013) Scott J Dixon et al. Nature Chemical Biology
- Systemic Iron Homeostasis
- (2013) Tomas Ganz PHYSIOLOGICAL REVIEWS
- A delicate balance: Iron metabolism and diseases of the brain
- (2013) Dominic Hare et al. Frontiers in Aging Neuroscience
- Mechanisms of Mammalian Iron Homeostasis
- (2012) Kostas Pantopoulos et al. BIOCHEMISTRY
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
- (2012) Peng Lei et al. NATURE MEDICINE
- Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
- (2012) Chuang Guo et al. NEUROCHEMISTRY INTERNATIONAL
- Impairment of Interrelated Iron- and Copper Homeostatic Mechanisms in Brain Contributes to the Pathogenesis of Neurodegenerative Disorders
- (2012) Tina Skjørringe et al. Frontiers in Pharmacology
- H-ferritin is the major source of iron for oligodendrocytes
- (2011) Bozho Todorich et al. GLIA
- Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders
- (2009) Eric Mills et al. Future Medicinal Chemistry
- Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
- (2008) Jack T. Rogers et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
- (2008) Wan Seok Yang et al. CHEMISTRY & BIOLOGY
- Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
- (2008) J. Salazar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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