Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux

(2019) Adrienne C. Dlouhy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safe coordinated trafficking of heme and iron with copper maintain cell homeostasis: modules from the hemopexin system

(2019) R. Vanacore et al.   BIOMETALS

Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)

(2019) Jiang Ying et al.   JOURNAL OF NEUROSCIENCE

Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures

(2019) David S. Knopman   NEW ENGLAND JOURNAL OF MEDICINE

Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes

(2019) Zheng Chen et al.   Scientific Reports

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

(2018) Abdel A. Belaidi et al.   Neurotherapeutics

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Dopaminergic Neurons Respond to Iron-Induced Oxidative Stress by Modulating Lipid Acylation and Deacylation Cycles

(2015) Sofía Sánchez Campos et al.   PLoS One

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease

(2014) Javier Becerril-Ortega et al.   NEUROBIOLOGY OF AGING

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

(2014) Vinod Udayar et al.   Cell Reports

Aβ-independent processes—rethinking preclinical AD

(2013) Gaël Chételat   Nature Reviews Neurology

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Hippocampal Iron Concentration and Hippocampal Volume in Age-Related Differences in Memory

(2012) K. M. Rodrigue et al.   CEREBRAL CORTEX

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE